Imbalanced Immune Response of T-Cell and B-Cell Subsets in Patients with Moderate and Severe COVID-19중등도 및 중증 COVID-19 환자에서 T- 세포 및 B- 세포 서브 세트의 불균형 면역 반응Article Published on 2021-09-302022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] acute COVID-19 analyzed B cell B cells B-cell B-cell subsets both groups Ccr6 CD27 CD38 CD45 CD45RA Cell circulating COVID-19 COVID-19 patients CRP dysregulated enrolled flow cytometry follicular Frequency group healthy donor humoral immune response Imbalance imbalanced immune response immunological change immunological changes Infection memory minute moderate multicolor flow cytometry oxygen Oxygen therapy PaO Patient phenotype Phenotypes predominant qSOFA reduced respiratory rate response severe COVID-19 significantly skewed SpO2 subset T-cell subsets Tfh Th cells Th17 with COVID-19 [DOI] 10.3390/v13101966 PMC 바로가기 [Article Type] Article
CD8 + PD-L1 + CXCR3 + polyfunctional T cell abundances are associated with survival in critical SARS-CoV-2–infected patientsCD8 + PD-L1 + CXCR3 + 다항식 T 세포 풍부도는 중요한 SARS-COV-2에 감염된 환자의 생존과 관련이 있습니다.Research Article Published on 2021-09-222022-08-31 Journal: JCI Insight [Category] SARS, 바이오마커, 치료법, [키워드] adaptive Adaptive immunity CD4 CD8 Cell circulating control mechanisms COVID-19 Critical CXCR3 CXCR5 Cytometry death Deceased determine effector memory effector T cell effector T cells fatal disease Frequency functional granzyme B HLA-DR Imbalance immunology Increased Infectious disease intensive care involved life-threatening mechanism memory T cell memory T cells outcome patients patients with COVID-19 PD-L1 perforin phenotype phenotypic Population Principal component principal component analysis proportion proportions provide SARS-CoV-2–infected patient separation Stage stem cell survival T cell T cell response T cells Teff Vaccine design Viral viral control viral infection [DOI] 10.1172/jci.insight.151571 PMC 바로가기 [Article Type] Research Article
Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and TherapiesSARS-COV-2에 의한 심근 손상 : 신흥 메커니즘 및 요법Review Published on 2021-09-212022-09-01 Journal: Viruses [Category] SARS, 유전자 메커니즘, 진단, 치료법, [키워드] acting action potential acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis arrhythmia ATP attack autophagy cause Cell cells coronavirus creating damage decrease direct infection docking drug early stage early stages Effect effective Endothelial cell endothelial cells energy energy metabolism evade heart host cell Host immune response Imbalance immune cells immune response immunosuppressive immunosuppressive therapy induce infect Inflammation inhibit ion homeostasis lead leads metabolism myocardial damage myocarditis necroptosis organ Potential treatment priming programmed cell death promote protease Protease inhibitor protease inhibitors Proteases pyroptosis receptor Replication respiratory RNA-dependent RNA polymerase ROS production SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus ssRNA stages therapy treatment of viral infection turn Vesicle Viral viral clearance viral docking viral entry viral replication viroporin [DOI] 10.3390/v13091880 PMC 바로가기 [Article Type] Review
The effect of low serum calcium level on the severity and mortality of Covid patients: A systematic review and meta‐analysisReview Article Published on 2021-09-172022-10-30 Journal: Immunity, Inflammation and Disease [Category] COVID-19, SARS, [키워드] 95% confidence interval acute respiratory syndrome Admission analyzed article assessments calcium clinical Clinical outcome Complication Comprehensive coronavirus coronavirus disease COVID COVID‐19 COVID‐19 COVID19 D‐dimer disease Effect Electrolytes Hospitalization Hypocalcemia Imbalance initial intensive care investigated Lymphocyte count Mortality Odds ratio Patient performed Prognosis Prognostic factor random Result SARS‐CoV‐2 SARS‐CoV‐2 serum calcium severity significantly suggested systematic review the disease [DOI] 10.1002/iid3.528 PMC 바로가기 [Article Type] Review Article
Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients폰 빌레브란트 인자와 ADAMTS13 축의 불균형은 코로나19 중환자에서 혈전 과정의 원인이라기보다는 오히려 강한 염증과 내피 손상의 바이오마커Article Published on 2021-09-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 바이오마커, [키워드] ADAMTS13 ADAMTS13 conformation Admission alveolar capillaries alveolar capillary Antigen Biological Biomarker Biomarkers Clinical features contribute coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients D-dimer deaths deficiency disintegrin driver Drivers elevated endothelial damage enrolled factor V fibrinogen hallmark hemolytic anemia hospital Imbalance Immune-mediated induce Inflammation Laboratory parameters male-to-female ratio median age microangiopathic hemolytic anemia microthrombi Microthrombosis Mortality open Patient patients Platelet Pulmonary embolism pulmonary embolisms purpura Quantitative reported Seven severe deficiency specificity thrombocytopenia thrombocytopenic purpura thrombotic thrombotic microangiopathy Thrombotic thrombocytopenic purpura type I von Willebrand factor vWF [DOI] 10.1111/jth.15445 PMC 바로가기 [Article Type] Article
Von Willebrand factor and ADAMTS13 activity as clinical severity markers in patients with COVID-19COVID-19 환자의 임상 중증도 마커로서의 폰 빌레브란트 인자 및 ADAMTS13 활성Article Published on 2021-08-012022-09-11 Journal: Journal of Thrombosis and Thrombolysis [Category] MERS, SARS, 바이오마커, [키워드] ADAMTS13 age and gender Antigen clinical outcomes Clinical severity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outpatient COVID-19 outpatients COVID-19 patient COVID-19 patients D-dimer diagnosed disease severity Endothelial dysfunction endothelial injury enrolled evaluate fibrinogen healthy individual highest hypercoagulability ICU patient ICU Patients Imbalance increase increase in Inpatient Inpatients intensive care intensive care unit lead lowest marker mechanism Medical conditions Non-COVID-19 Patient patients with COVID-19 plasma predict Prospective Study prothrombotic state recruited reduction reduction in thrombotic thrombotic risk von Willebrand factor vWF were measured with COVID-19 [DOI] 10.1007/s11239-021-02457-9 PMC 바로가기 [Article Type] Article
Th2/Th1 Cytokine Imbalance Is Associated With Higher COVID-19 Risk MortalityTh2/Th1 사이토 카인 불균형은 더 높은 Covid-19 위험 사망률과 관련이 있습니다.Genetics Published on 2021-07-162022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] ACE2 expression addition Admission Affect age airway Analysis analyzed approach Asthma asthma patient asthma patients asthmatic CD4 COVID-19 COVID-19 severe respiratory syndrome cytokine death Deceased determined by died enrichment score evaluated Gene Expression healthy healthy controls Hospital admission hospitalized patient hospitalized patients Imbalance immune response Linear regression male Mortality Mount Sinai Mount Sinai Health System multi-organ inflammatory response nasal epithelium non-infected Older age outcome Patient patient reported patients patients hospitalized phenotype positive predict proteomics respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV2 infection sera serum serum proteomics severe respiratory syndrome Sex significantly smoker Smokers smoking smoking status sputum suggested System T cell T cells T-cells Th1 Th1 pathway Th17 Th2 Th2 pathway the SARS-CoV-2 virus those that survived type 2 helper Variation [DOI] 10.3389/fgene.2021.706902 PMC 바로가기 [Article Type] Genetics
COVID-19 infection in severe Alpha 1-antitrypsin deficiency: Looking for a rationale중증 알파 1 항트립신 결핍증의 COVID-19 감염: 근거 찾기Review Published on 2021-07-012022-09-11 Journal: Respiratory medicine [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] 95%CI Administered Alpha Alpha1-antitrypsin antiprotease antitrypsin caused clinical manifestation clinical manifestations clinical outcomes Cohort collected collected data Comorbidities Comorbidity COPD COVID-19 COVID-19 infection COVID-19 symptoms death rate deficiency diabetes disease emphysema Frequency General population genetic disorder highlight hospital Hospitalization hypertension Imbalance increased risk Infection Infectious disease Italian Italy laboratory-confirmed lead Lung disease Lung diseases malignancy National Patient preliminary finding Premature proteinase rare disease Relative risk reported resulting risk SARS-COV-2 infection SERPINA1 SERPINA1 gene spread of COVID-19 subject Surveillance symptomatic SARS-CoV-2 infection telephone survey total population Treatment [DOI] 10.1016/j.rmed.2021.106440 PMC 바로가기 [Article Type] Review
Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients코로나19 환자의 중증도에 대한 ACE1(지오텐신 전환 효소 1) 유전자의 I/D 다형성의 영향Article Published on 2021-07-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE ACE I/D polymorphism ACE1 ACE2 ACE2 receptor acute respiratory disease acute respiratory syndrome ADRS allele angiotensin angiotensin I Angiotensin II Angiotensin-converting enzyme association Asymptomatic binding cause Chain Reaction China Clinical outcome Corona virus coronavirus COVID-19 COVID-19 patient detect diabete diabetes disease etiology facilitate followed by Frequency Genotype genotyped host cell hypertension I/D I/D polymorphism Imbalance Impact incidence Interaction Lung injury marker Older age Pathogenesis Patient polymerase chain polymerase chain reaction Predictive researcher respiratory risk RT-PCR SARS-CoV-2 SARS-CoV2 Severe acute respiratory syndrome Severe acute respiratory syndrome corona virus-2 severe COVID-19 severe lung injury severity severity of COVID-19 significantly significantly higher SPSS statistical analysis susceptibility syndrome These data Version [DOI] 10.1016/j.meegid.2021.104801 PMC 바로가기 [Article Type] Article
Scientific Hypothesis for Treatment of COVID-19’s Lung Lesions by Adjusting ACE/ACE2 ImbalanceACE/ACE2 불균형을 조정하여 COVID-19의 폐 병변 치료를 위한 과학적 가설Article Published on 2021-06-012022-09-11 Journal: Cardiovascular toxicology [Category] SARS, 치료제, [키워드] ACE ACE-2 Adjusting angiotensin approach Cardiovascular function caused clinical trials coronavirus SARS-CoV-2 country COVID-19 COVID-19 infection deaths effective vaccine Effective vaccines entry receptor global pandemic Imbalance knowledge lesion modulating new coronavirus SARS-CoV-2 occurred pharmacological Prevent preventive measure preventive measures protective role Protein RAS Regulation Renin respiratory tract SARS-CoV-2 SARS-COV-2 infection Spread Stage stages treat Variation variations viral infection virus Wuhan Wuhan, China [DOI] 10.1007/s12012-021-09649-y PMC 바로가기 [Article Type] Article