Biophysical and Biochemical Characterization of the Receptor Binding Domain of SARS-CoV-2 VariantsArticle Published on 2022-10-012022-11-16 Journal: The protein journal [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 adopted affinity antibody biochemical characterization Degradation help host cell receptor host receptor immune response immunological IMPROVE increase in infected individual interact Intervention medical intervention mutant Mutation mutations natural selection neutralizing antibody parental protease Rapid RBD receptor Receptor binding domain responses SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant sensitivity the RBD thermal stability Transmissibility understanding variant variants variants of concern [DOI] 10.1007/s10930-022-10073-6 PMC 바로가기
Characteristics and outcomes of SARS-COV 2 critically ill patients after emergence of the variant of concern 20H/501Y.V2: A comparative cohort studyArticle Published on 2022-09-302022-11-16 Journal: Medicine [Category] SARS, 변종, [키워드] 24 hours 95 % CI 95% CI 95% confidence interval absence Admission Analysis change Characteristics cohort of patient cohort study Complete coronavirus 2 Critical care Critically ill patient demographic data dominant expected Fever forest higher risk ICU immunological improvement increased risk Indian Ocean indicated intensive care Invasive mechanical ventilation island less Lineage management Mayotte Mortality outcome outcomes Patient patients performed respiratory Respiratory failure SARS-CoV-2 second wave severe patients severity suggested survival Transmissibility unique VAP variant Ventilator-associated pneumonia Viral genome sequencing VoC [DOI] 10.1097/MD.0000000000030816 PMC 바로가기
Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profileArticle Published on 2022-09-272022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] 229E antibodies antibody Barcelona Blood blood sample C-terminus cause chemokine collected Concentration concentrations COVID-19 cytokine level cytokine levels cytokine profile cytokine response Cytokines distress domain EGF FGF full-length growth factor higher risk HKU1 human coronavirus Humoral response IFN-α IgA level IgG IgM IL-15 IL-17 IL-7 immune response immunological increased risk induce Infection Inflammatory investigated male Maternal maternal and neonatal immunity mother Neonatal Newborn NL63 non-infected nucleocapsid OC43 outcome outcomes positive positive correlation positive for rRT-PCR Pregnancy pregnant women Preterm birth profiles Questionnaires RANTES recruited reduction robust rRT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2-specific IgG SARS-CoV-2-specific IgGs serology severe COVID-19 Spain Swab Symptom symptomatic tested transfer transplacental transfer. Vaccines variables was increased were infected were recorded women [DOI] 10.3389/fimmu.2022.999136 PMC 바로가기
Single-Cell Gene Expression Analysis Revealed Immune Cell Signatures of Delta COVID-19Article Published on 2022-09-212022-11-16 Journal: Cells [Category] SARS, 변종, 유전자 메커니즘, [키워드] accompanied accompany adaptive B.1.617 Blood caused Characteristics contribute coronavirus disease correlated COVID-19 COVID-19 pathogenesis Cytokine storm Delta delta variant diagnostic dominant Factor Gene Expression gene expression signature high mortality highlight immune immune component immune response immune system Immunity immunological individual Infection Lineage lymphoid molecular monocyte Monocytes mononuclear cell Multiple myeloid cells pathway performed proinflammatory required Revealed risk SARS-CoV-2 SARS-CoV-2 lineage severity signature significant changes in single-cell syndrome targeted therapy therapeutic Transcriptome understanding variant virus with COVID-19 [DOI] 10.3390/cells11192950 PMC 바로가기
Saliva is suitable for SARS-CoV-2 antibodies detection after vaccination: A rapid systematic reviewArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] 95% CI Ad26 analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 vaccination antibodies antibody Antibody detection Antibody titer applied assays AstraZeneca convalescent individual correlation COVID-19 COVID-19 vaccines eligible ELISA assay evaluate flow cytometry highlight IgA IgG Immunity immunoassay Immunoglobulin immunological increasingly infected individuals janssen Johnson & Johnson lack moderate mRNA-based mucosal Neutralizing nine quantification reached reported Saliva salivary SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 detection selected serological test serum serum/plasma systematic review vaccinated individual vaccination Vaccination strategy Vaccine Web of Science [DOI] 10.3389/fimmu.2022.1006040 PMC 바로가기
COVID-19 cross-sectional study in Maricá, Brazil: The impact of vaccination coverage on viral incidenceArticle Published on 2022-09-192022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, 치료기술, [키워드] anti-SARS-CoV-2 Brazil correlated Coverage COVID-19 cross-sectional delta variant detectable disease greater group highlighting IgG IgG antibody Immunity immunological incidence incidence of COVID-19 individual neutralizing antibody occurred performed Population proportion Rio de Janeiro SARS-CoV-2 subjects Support Surveillance Transmission vaccinated individual vaccination Vaccine variant widespread [DOI] 10.1371/journal.pone.0269011 PMC 바로가기
Rapamycin and inulin for booster vaccine response stimulation (RIVASTIM)-rapamycin: study protocol for a randomised, controlled trial of immunosuppression modification with rapamycin to improve SARS-CoV-2 vaccine response in kidney transplant recipientsArticle Published on 2022-09-152022-11-15 Journal: Trials [Category] SARS, 진단, [키워드] 1:1 binding domain Booster vaccine cell-mediated response clinical Controlled trial COVID COVID-19 COVID-19 vaccination COVID-19 vaccine death develop disease severity dose Effectiveness Efficacy ENhance hospitalisation humoral hypothesise IgG immune cell population immunological Immunosuppression IMPROVE include increased risk Intervention kidney transplant recipient kidney transplant recipients Kidney transplantation live SARS-CoV-2 Modification mTOR inhibitor multicentre neutralisation New outcome participant Prednisolone Primary outcome proportion Protective protective immunity public health randomised randomised controlled trial Rapamycin recipient reduce reduced regimen registry responses SARS-CoV-2 SARS-CoV-2 vaccine secondary serological Sirolimus Standard of care Study protocol Tolerability Trial vaccination Vaccine vaccine response virus [DOI] 10.1186/s13063-022-06634-w PMC 바로가기
The choroid plexus and its role in the pathogenesis of neurological infectionsArticle Published on 2022-09-102022-11-15 Journal: Fluids and Barriers of the CNS [Category] SARS, 치료기술, 치료제, [키워드] Activation Alter bidirectional Blood–CSF barrier Borrelia Borrelia burgdorferi Brain Cell cells cellular response Central nervous system cerebrospinal fluid changes in chemotaxis choroid Choroid plexus circulating CNS CNS disorder cytokine dendritic cells develop Diseases disorder driving epithelia epithelial epithelial cell function greater highlight homeostasis homing hydrocephalus Immune cell immune cells immune response Immunity immunological Including induce Infection infections Inflammation inflammatory signal John Cunningham virus junction knowledge less macrophages Neuroinflammation neurological pathogen Pathogenesis Pathogens pharmacological intervention promote provide Research SARS-CoV-2 shown T cells target these cell virus Zika virus [DOI] 10.1186/s12987-022-00372-6 PMC 바로가기
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactionsArticle Published on 2022-09-082022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] accompanied Activation animal model bioinformatics cells characterized chemokine COVID-19 COVID-19 patients E protein expression Extracellular matrix immune immune response immunological immunomodulatory property Inflammation Interaction intrinsic kinases lipid metabolism Loss of Smell machine metabolic molecular multifunctional olfactory Protein proteome proteomic proteomics receptor reveal SARS-CoV-2 secretion Signaling Smell structural protein survival Symptom TGF-beta signaling the SARS-CoV-2 These data trajectory transcriptomics tyrosine virion widespread [DOI] 10.3389/fimmu.2022.866564 PMC 바로가기
Leveraging South African HIV research to define SARS-CoV-2 immunity triggered by sequential variants of concernArticle Published on 2022-09-012022-11-15 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome African antigenic assays B cell cause Combination coronavirus coronavirus disease COVID-19 cross-reactive cross-reactive antibodies driving elicited Epidemic Frequency genomic highlight HIV HIV vaccine Hybrid immunity immune response Immunity immunogenic immunological immunology Infection mutated variants pandemic platform population immunity Prevent Region Research respiratory viruses respond response responses SARS-CoV-2 SARS-CoV-2 immunity shown South Surveillance the SARS-CoV-2 to define triggered vaccination Vaccine variants variants of concern virus VoC [DOI] 10.1111/imr.13086 PMC 바로가기