Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor MicroenvironmentImmunology Published on 2021-04-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulating Acidic activate addition Amino acid amino acid transporter anti-tumor immunity c-MYC Cancer caused Cell cell metabolism chimeric antigen receptor demonstrated ENhance Evidence Express expression function functions Glucose Glutamine growth hypoxic Immune cell immune cells immunometabolism Immunotherapy induce infiltration Invasion leucine limitation metabolism metabolites mTORC1 Natural killer cells nutrient transporters overcome plasma membrane Potential proliferation promote regulatory pathway required robust SLC1A5 SLC3A2 SLC7A5 Strategy subcellular subunit T cells targeting therapy transcription factor Tumor tumor microenvironment tumors [DOI] 10.3389/fimmu.2021.624324 PMC 바로가기 [Article Type] Immunology
Aging and monocyte immunometabolism in COVID-19Editorial Published on 2021-04-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, SARS, [키워드] aging COVID-19 immunometabolism immunosenescence inflammaging monocyte Monocytes [DOI] 10.18632/aging.202918 PMC 바로가기 [Article Type] Editorial
Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized PhospholipidsReview Published on 2021-03-152023-06-14 Journal: Frontiers in Endocrinology [Category] MERS, [키워드] Atherosclerosis COVID-19 immunometabolism Inflammasome Inflammation lung oxidized phospholipids oxPAPC [DOI] 10.3389/fendo.2021.626842 PMC 바로가기 [Article Type] Review
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients대사 프로그램은 중증 COVID-19 환자의 역기능 면역 반응을 정의합니다Article Published on 2021-02-262022-09-12 Journal: Cell Reports [Category] MERS, SARS, 진단, [키워드] Abstract accompanied acute COVID-19 anion Apoptosis caspase Cell channel Characteristics coronavirus disease COVID-19 COVID-19 patient develop disease disease severity Elderly patient Express functional highlight identify Immune cell immune response immunological immunology immunometabolism increase in increases in Infection inhibited lymphopenia MDSCs metabolic metabolic pathway metabolism Mild Mitochondria mitochondrial mitochondrial dysfunction myeloid cell observé oligomerization Patient phenotype Population predict provide regimens SARS-CoV-2 SARS-CoV-2 patient severe COVID-19 patient severe disease T cell T cells therapeutic therapeutic target these cell Thompson unique VDAC1 viral infections [DOI] 10.1016/j.celrep.2021.108863 PMC 바로가기 [Article Type] Article
Could targeting immunometabolism be a way to control the burden of COVID-19 infection?Review Published on 2021-01-202023-06-15 Journal: Microbes and infection [Category] MERS, SARS, [키워드] Anti-metabolite therapy COVID-19 immunometabolism metabolic disease nutrition SARS-CoV-2 [DOI] 10.1016/j.micinf.2021.104780 PMC 바로가기 [Article Type] Review
Macrophage Plasticity in Reproduction and Environmental Influences on Their FunctionReview Published on 2021-01-142023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Air pollution breast milk immunometabolism Infection macrophage plasticity obesity Placenta uterus [DOI] 10.3389/fimmu.2020.607328 PMC 바로가기 [Article Type] Review
Targeting immunometabolism to treat COVID-19Targeting Immunometabolism Published on 2021-01-022022-10-30 Journal: Immunotherapy Advances [Category] COVID-19, [키워드] agonist anti-viral agents Antiviral antiviral therapy Cell COVID-19 COVID-19 crisis derivative disease severity elicit Evidence functions hyper-inflammatory response Immune cell immunometabolism immunomodulatory immunomodulatory property indicate inflammatory phase Inflammatory response innate immune reprogramming investigated Macrophage metabolite offer potential therapy pro-inflammatory recent receptor Research researcher SARS-CoV-2 shown targeting the disease treat undergo viral infection with COVID-19 zoonoses [DOI] 10.1093/immadv/ltab013 PMC 바로가기 [Article Type] Targeting Immunometabolism
Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19코로나19 염증, 면역노화, 자가면역의 초석에 있는 면역대사Review Published on 2020-12-312022-09-01 Journal: Aging (Albany NY) [Category] MERS, SARS, 바이오마커, 진단, [키워드] approach Autoimmune Autoimmunity common factor Comorbidities Comorbidity COVID-19 COVID-19 treatment dimethyl fumarate dysregulation fumarate immunometabolism immunosenescence inflammaging leads manifestation metformin occur opens Patient Prevent Rapamycin rapamycin-metformin-dimethyl fumarate risk severe COVID-19 severe disease SLE T-cell T-cell dysfunction T-cells targeting therapeutic strategy Treatment [DOI] 10.18632/aging.202422 PMC 바로가기 [Article Type] Review
Interferon‐stimulated gene products as regulators of central carbon metabolismViewpoint Published on 2020-12-012022-10-31 Journal: The Febs Journal [Category] Coronavirus, MERS, SARS, [키워드] activate analyses Antigen antiviral immune response antiviral response biochemical carbon metabolism cellular COVID‐19 eicosanoid enzyme Evidence expression GAPDH gene product help immune response immunometabolism individual inhibit inhibiting innate immune response innate immune system interfere ISG ISGs mechanism metabolic product metabolite modulate modulating NFAT nitric oxide NOS Pathways performed Protein Proteins reaction regulate RSAD2 SAM stimulate Support viperin viral disease viral infections viral life cycle Viral proteins viral replication viruses [DOI] 10.1111/febs.15625 PMC 바로가기 [Article Type] Viewpoint
The effects of aging on host resistance and disease tolerance to SARS‐CoV‐2 infectionSARS-CoV-2 감염에 대한 숙주 저항 및 질병 내성에 대한 노화의 영향Review Published on 2020-11-172022-09-10 Journal: The Febs Journal [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect aging alteration approach approaches asymptomatic infection cardiovascular disease cardiovascular diseases caused Clinical outcome Comorbidities Comorbidity complications coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 crisis declining Defense diabetes Diabetes Mellitus disease disrupt Disruption Effect elderly elderly patients elevated ER stress febrile illness Health higher risk highest Host host defense host response host responses immune functions immunometabolism immunosenescence IMPROVE individual individuals knowledge management mechanism metabolic processes Mild mitochondrial mitochondrial dysfunction molecular mechanism molecular mechanisms outcome pandemic Patient predisposition promote PROTECT pulmonary immunopathology resistance respiratory Respiratory disease risk SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severe disease severe respiratory disease suppress Tolerance tolerance mechanism Treatment triggered unfolded protein response Viral viral infection viral replication viruses [DOI] 10.1111/febs.15613 PMC 바로가기 [Article Type] Review