Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression
K18-hACE2 마우스의 치명적인 신경 보급 및 SARS-CoV-2 향성은 hACE2 발현에 부분적으로만 의존합니다
Article
[키워드] ACE2
ACE2 protein
ACE2-expressing cell
ACE2-expressing cells
Analysis
angiotensin
animal
animal models
AT1
axonal transport
blood-brain barrier
Brain
bronchiolar
Cell
Cohort
comparative pathology
COVID-19
Critical
cytokeratin
cytokeratin 18 promoter
days post-infection
death
Dependent
detectable
dose
ENhance
epidemiological data
euthanasia
evaluated
Evidence
expressing
expression
hACE2
Human
human Angiotensin-converting enzyme
Human angiotensin-converting enzyme 2
hypothermia
immunohistochemistry
In situ hybridization
in vivo
in vivo imaging
independent
independent of
inoculated
intranasal
K18-hACE2
Lineage
Mild-to-moderate
neuroepithelium
Neuron
neurons
occur
olfactory
olfactory bulb
olfactory neuroepithelium
overexpression
pathologic
PFUs
Pneumocytes
Pneumonia
portal
question
resulting
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 pathogenesis
spatiotemporal
subsequent
transgenic mice
translational
translational animal model
Transmission
transmission electron microscopy
Transport
tropism
vasculature
viral pathogenesis
Viremia
Virological
[DOI] 10.3390/v14030535 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/v14030535 PMC 바로가기 [Article Type] Article