The Impact of SARS-CoV-2 Infection in Patients with Inborn Errors of Immunity: the Experience of the Italian Primary Immunodeficiencies Network (IPINet)Article Published on 2022-07-012023-07-08 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), [키워드] COVID-19 inborn errors of immunity outcome SARS-CoV-2 Seroconversion viral shedding [DOI] 10.1007/s10875-022-01264-y PMC 바로가기
SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency: Findings from the COV-AD Study항체 결핍증이 있는 개인의 SARS-CoV-2 백신 반응: COV-AD 연구 결과Article Published on 2022-07-012022-09-12 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Antibiotic prophylaxis antibody Antibody Response assays AstraZeneca Breakthrough infection cellular response clearance Cohort controls COVID-19 CVID deficiency determine dose Efficacy ELISA Evidence finding General population healthy control IgG immune response immunoglobulin replacement therapy Inborn error inborn errors of immunity individual Infection interferon gamma less magnitude morbidity and mortality nasopharyngeal swabs neutralisation neutralising no difference occurred participant Patient PCR PCR positive Pfizer/BioNTech post vaccination Prevent Primary Immunodeficiency receiving recipient recruited recurrent infection reduced remained reported respond response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine secondary secondary antibody secondary immunodeficiency seropositive Seropositivity significantly T cell response the antibody response vaccination Vaccine Vaccines [DOI] 10.1007/s10875-022-01231-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defectsReview Published on 2022-06-252023-07-09 Journal: Acta biochimica et biophysica Sinica [Category] COVID19(2023년), [키워드] COVID-19 DNA repair mechanism inborn errors of immunity Primary Immunodeficiency [DOI] 10.3724/abbs.2022071 PMC 바로가기 [Article Type] Review
Increased Seroprevalence and Improved Antibody Responses Following Third Primary SARS-CoV-2 Immunisation: An Update From the COV-AD Study3차 1차 SARS-CoV-2 예방접종 후 혈청유병률 증가 및 항체 반응 개선: COV-AD 연구의 업데이트Article Published on 2022-06-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Anti-spike antibody Antibody Response AstraZeneca B.1.1.529 cellular immunity cellular response ChAdOx1 ChAdOx1 nCoV-19 cohort of patient COVID-19 cross-reactive CVID deficiency detectable determine dose ELISA ELISpot assays ENhance enrolled glycoprotein healthy control healthy controls heterogeneous heterologous vaccine humoral Humoral immunity immunodeficiency immunogenicity Improved Inborn errors inborn errors of immunity Increased individual initial magnitude mounted neutralisation neutralising no differences participant Pfizer Primary Immunodeficiency remained response SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine secondary antibody secondary immunodeficiency Seroconversion serological response seronegative Seroprevalence significantly increased significantly lower significantly more Support T cell T cell response the antibody response the SARS-CoV-2 These data vaccination Vaccine vaccine dose vaccine doses variant widespread [DOI] 10.3389/fimmu.2022.912571 PMC 바로가기 [Article Type] Article
Immunogenicity of the mRNA-1273 COVID-19 vaccine in adult patients with inborn errors of immunity선천성 면역이상이 있는 성인 환자에서 mRNA-1273 코로나19 백신의 면역원성Controlled Clinical Trial Published on 2022-06-012022-09-12 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome All participant antibodies antibody Antibody Response Antibody titer baseline binding Cellular immune response CID clinically cohorts comparable Complication complications Control coronavirus correlated COVID-19 COVID-19 vaccination COVID-19 vaccine CVID deficiencies deficiency dose first vaccination healthy controls humoral immune response Immunity immunodeficiency immunogenic immunogenicity immunosuppressive drug Inborn error inborn errors of immunity increased risk Level Mild mRNA-1273 mRNA-1273 COVID-19 vaccine multicenter Neutralizing antibodies Patient patient group patients patients with CVID phagocyte Primary immunodeficiency disorders SARS-CoV-2 second vaccination seroconversion rate T-cell T-cell Response the antibody response vaccination against COVID-19 Vaccinations were assessed X-linked agammaglobulinemia XLA [DOI] 10.1016/j.jaci.2022.04.002 PMC 바로가기 [Article Type] Controlled Clinical Trial
Rare Variants in Inborn Errors of Immunity Genes Associated With Covid-19 SeverityOriginal Research Published on 2022-05-272023-06-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, [키워드] COVID-19 gene-level tests inborn errors of immunity pathway-based analysis PPI network analysis [DOI] 10.3389/fcimb.2022.888582 PMC 바로가기 [Article Type] Original Research
Case Report: X-Linked SASH3 Deficiency Presenting as a Common Variable Immunodeficiency증례 보고서: 공통 변수 면역 결핍으로 나타나는 X-연관 SASH3 결핍Case Reports Published on 2022-04-082022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] age Autoimmune B cell bilateral pneumonia CD4 CD8 cells combined immunodeficiency common common variable immunodeficiency CVID deficiency described diagnosed dysregulation elevated Genetic testing genetics Haemophilus influenzae Haemophilus influenzae type b humans IgG and IgM immune dysregulation Immunity immunodeficiency immunological phenotype Inborn errors inborn errors of immunity Infection infections Influenza influenza infection loss-of-function lymphopenia memory B cells mucosal Mutation naïve T cells Patient patients phenotype polysaccharide primary immunodeficiencies. proliferation Protein reduced reported RNA SARS-CoV-2 SASH3 SASH3 deficiency Signaling Streptococcus pneumoniae survival T cell T cell activation T cells T-cell TCR Vaccine variable variant varicella Varicella zoster virus viral infection viral infections virus X-linked [DOI] 10.3389/fimmu.2022.881206 PMC 바로가기 [Article Type] Case Reports
Insights From Early Clinical Trials Assessing Response to mRNA SARS-CoV-2 Vaccination in Immunocompromised Patients면역 저하 환자에서 mRNA SARS-CoV-2 백신 접종에 대한 반응을 평가하는 초기 임상 시험의 통찰력Review Published on 2022-03-042022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] adaptive administration agonist animal model Anti-CD19 anti-CD20 anti-CD38 Assessing BNT162b2 CD4 clinical clinical trial component COVID-19 Critical CTLA4 deficiency dose effective Genetic healthy humans immune systems Immunocompromised Immunocompromised patient immunodeficiency Immunosuppressed Immunosuppressive medication inborn errors of immunity increased risk insight jak inhibitors knowledge mRNA mRNA vaccination mRNA vaccine mRNA-1273 mRNA1273 Patient predictor PROTECT response SARS-CoV-2 SARS-CoV-2 vaccination severe disease T-cell the vaccine therapeutic Therapies transplantation Treatment Trial tyrosine vaccination Vaccine [DOI] 10.3389/fimmu.2022.827242 PMC 바로가기 [Article Type] Review
Risk Factors for Severe COVID-19 and Hospital Admission in Patients With Inborn Errors of Immunity – Results From a Multicenter Nationwide StudyMulticenter Study Published on 2022-02-282023-07-08 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] COVID-19 Hospital admission inborn errors of immunity Mortality Risk factors SARS-CoV-2 [DOI] 10.3389/fimmu.2022.835770 PMC 바로가기 [Article Type] Multicenter Study
Atypical Ataxia Presentation in Variant Ataxia Telangiectasia: Iranian Case-Series and Review of the Literaturearticle Published on 2022-01-142024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] ataxia-telangiectasia Atypical presentation Autoimmunity inborn errors of immunity late-ataxia mild phenotype Primary Immunodeficiency [DOI] 10.3389/fimmu.2021.779502 PMC 바로가기 [Article Type] article