Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome항인지질 증후군에서 면역혈전증과 혈관병증의 기전Review Published on 2022-05-012022-09-12 Journal: Seminars in immunopathology [Category] MERS, 진단, [키워드] activated antibody antiphospholipid antibody Antiphospholipid syndrome Autoimmune cell proliferation cells characterized circulating Coagulation Coagulopathy complement complications COVID-19 develop disease driver endothelial cells event expand Extracellular Factor fibrinolytic highlight immunothrombosis infiltration marker NETs Neutrophil extracellular trap Neutrophil extracellular traps occlusive organ damage pathogenic pathophysiology Patient phospholipid Platelets Protein recognize similarity syndrome thrombosis vascular thrombosis Vasculopathy [DOI] 10.1007/s00281-022-00916-w PMC 바로가기 [Article Type] Review
COVID-19 Vaccine-Induced Multisystem Inflammatory Syndrome With Polyserositis Detected by FDG PET/CTFDG PET/CT로 검출된 다발성 장막염을 동반한 코로나19 백신 유발 다계통 염증 증후군Case Reports Published on 2022-05-012022-09-11 Journal: Clinical nuclear medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] administration Adverse reaction BNT162b2 BNT162b2 mRNA C-reactive protein condition Corticosteroids COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines elevated evaluate FDG Fever High-dose Immune-mediated infiltration Inflammatory Pericarditis pericardium Peritoneum peritonitis PET/CT Polyserositis Prolonged fever reported resolved serum serum C-reactive protein Symptom syndrome systemic inflammation systemic symptom the patient Treatment [DOI] 10.1097/RLU.0000000000004094 PMC 바로가기 [Article Type] Case Reports
Chronic Inflammatory Placental Disorders Associated With Recurrent Adverse Pregnancy Outcome반복적인 임신 부작용과 관련된 만성 염증성 태반 장애Review Published on 2022-04-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulate Activation Adverse aetiology Allograft allograft rejection association Autoimmune diseases CD68 CD68+ CD8+ CD8+ T lymphocyte CD8+ T lymphocytes chorionic chronic chronic histiocytic intervillositis chronic placental inflammation clinical consequences death diagnosed Diagnosis diagnostic disorder Disruption early-onset etiology excluded exclusion Features fetal fetal death fetal growth restriction fetus FIBRIN Gas exchange growth hallmark histopathological histopathological examination immune Immune cell immune cells Immunosuppression Infection infiltration Inflammatory inflammatory disorder intervillous space intrauterine fetal death Lymphocytes macrophages massive massive perivillous fibrin deposition miscarriage mother normal pregnancy observation outcome pathology Placenta placental pregnancies Pregnancy Prevalence Prevent Prophylaxis recurrence Recurrent rejection risk SARS-CoV-2 Stillbirth subsequent syndrome T lymphocytes villitis of unknown etiology. [DOI] 10.3389/fimmu.2022.825075 PMC 바로가기 [Article Type] Review
Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages단핵구 및 대식세포의 케모카인 수용체 유전자 조절과 관련된 심각한 COVID-19 관련 변이체Article Published on 2022-04-142022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] 3D genome organization 3p21.31 association CCR1 CCR2 CCR5 Chemokine receptor chromatin Control COVID-19 CTCF elevated epigenomic Gene regulation Genes Genetic genetic association Genome Genome-wide association studies GWAS hallmark Hospitalization increased expression infiltration inflammatory monocyte inflammatory monocytes locus Macrophage macrophages mechanism monocyte Monocytes organ rationale Regulatory regulatory element risk SARS-CoV-2 SARS-COV-2 infection severe COVID-19 SNP variant [DOI] 10.1186/s13059-022-02669-z PMC 바로가기 [Article Type] Article
Th2-Oriented Immune Serum After SARS-CoV-2 Vaccination Does Not Enhance Infection In VitroSARS-CoV-2 백신 접종 후 Th2 지향 면역 혈청은 시험관 내 감염을 증가시키지 않습니다Article Published on 2022-04-082022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] accompanied acute respiratory syndrome ADE Adjustment adjuvant aluminum aluminum adjuvant Antibody-dependent enhancement antibody-dependent enhancement of infection Antigen cell line coronavirus Efficacy examined expression pattern Fc receptors Human immune Immune cell immunization immunopathology in vitro inactivated Inactivated SARS-CoV-2 vaccine Infection infiltration lung MERS-CoV mice Middle East neutralizing antibody Neutralizing antibody titer preclinical study Pseudotyped virus respiratory syndrome coronavirus response risk S1 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 virus sera serum Spike protein spike protein subunit vaccine. subunit T helper tested Th2 the SARS-CoV-2 Vaccine virus [DOI] 10.3389/fimmu.2022.882856 PMC 바로가기 [Article Type] Article
Does SARS-CoV-2 affect neurodegenerative disorders? TLR2, a potential receptor for SARS-CoV-2 in the CNS Reviews Published on 2022-04-082022-10-05 Journal: Experimental & Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] accumulating ACE2 ACE2 expression addition Affect Alzheimer’s disease binding caused Central nervous system CNS component components coronavirus COVID-19 Critical disease highlight identify infected patients Infection infiltration innate immune Interaction Lungs microbial neurodegenerative Neurological symptom pandemic Parkinson’s disease Pathogenesis pathogenic mechanism pathology patients Protein receptor recognize Respiratory system resulting SARS-CoV-2 SARS-COV-2 infection seeking shown therapy TLR2 unlikely viral entry virus [DOI] 10.1038/s12276-022-00755-7 [Article Type] Reviews
Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascadeShort communication Published on 2022-04-012022-10-05 Journal: Biochemical and Biophysical Research Communication [Category] 신약개발, [키워드] acute lung injury ameliorated attenuate cascade cytoplasmic drug escitalopram HDAC4 IC50 infiltration Inflammatory responses inhibited inhibiting investigated Lung injury mice morbidity and mortality neutrophil NF-κB signaling nucleus p65 pathway pro-inflammatory cytokine promoted pulmonary injury reduced SIK2 translocated Treatment triggered [DOI] 10.1016/j.bbrc.2022.02.015 [Article Type] Short communication
New Approach for Targeted Treatment of Mild COVID-19 by Honeysuckle through Network Pharmacology Analysis네트워크 약리학 분석을 통한 인동덩굴의 경증 COVID-19 표적 치료를 위한 새로운 접근 방식Research Article Published on 2022-02-212022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] COVID19(2023년), MERS, SARS, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] Analysis Cell Chinese CIBERSORT collected complex component coronavirus disease Coronavirus disease 2019 correlated Correlation analysis COVID-19 Data quality database differentially expressed differentially expressed gene effective enrichment analysis evaluated expression expressions FIVE Gene Expression Omnibus Genes GEO hematopoietic stem cells honeysuckle Immune cell infiltration immune cells immune signaling pathways Infection infiltration ingredient MAP3K7 mechanism Medicine Mild molecular natural killer network New NK cell NK cells objective overlapping Patient pharmacokinetics pharmacological Pharmacology positive correlation predict proportion protective effect RELA Result Safe screened Seven significantly statistically significant suggested target targets TCMSP toolkit Traditional Traditional Chinese medicine Transcriptome was related [DOI] 10.1155/2022/9604456 PMC 바로가기 [Article Type] Research Article
Increased Interleukin 18-Dependent Immune Responses Are Associated With Myopericarditis After COVID-19 mRNA Vaccination증가된 인터루킨 18 의존성 면역 반응은 COVID-19 mRNA 백신 접종 후 심근염과 관련이 있습니다Immunology Published on 2022-02-182022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] abnormality activated Activation administration Cardiac complications caused CD68 Cell characterized chest pain circulating Control controls COVID-19 COVID-19 mRNA Vaccination COVID-19 mRNA vaccine COVID-19 vaccination cytokine Cytokines disease onset dysfunction elevated expressed first dose Flow cytometry analysis healthy individual hearts IL-18 IL-27 Immune profile immune response incidence Increased individuals infiltration interleukin interleukin 18 mechanism mice Mild monocyte mRNA mRNA-1273 COVID-19 vaccine multiplex Myopericarditis NK cell NK cells NLRP3 inflammasome occur Patient phenotype progression response T cell Th1-type immune response the patient troponin I upstream vaccinated individual vaccination were used with COVID-19 [DOI] 10.3389/fimmu.2022.851620 PMC 바로가기 [Article Type] Immunology
Morphologically, immunohistochemically and PCR proven lymphocytic viral peri-, endo-, myocarditis in patients with fatal COVID-19치명적인 COVID-19 환자에서 형태학, 면역조직화학 및 PCR로 입증된 림프구성 바이러스성 심근주위, 내막, 심근염Short Report Published on 2022-02-172022-09-11 Journal: Diagnostic Pathology [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] absence antibody cardiac injury CD20 CD3 characterized clinically coronavirus Coronavirus infection COVID-19 criteria criterion determine diagnosed diagnosis of COVID-19 eight Elderly patient Endocarditis eosin Evidence evidence of expression fatal COVID-19 female heart hematoxylin Hematoxylin and eosin histological Inclusion Increased increased expression Infection infiltration Inflammation Injury less Lymphocytes lymphocytic myocarditis male Microvascular thrombosis Morphological Morphological and immunohistochemical study myocarditis Myocardium neutrophil Neutrophils New coronavirus Patient PCR perforin Pericarditis Pneumonia positive PCR positive result reported Result RNA SARS-CoV-2 staining T lymphocyte T lymphocytes thrombosis TLR Toll-like receptor Toll-like receptors Van Gieson Viral viral myocarditis Viral pneumonia Viral RNA was performed [DOI] 10.1186/s13000-022-01207-6 PMC 바로가기 [Article Type] Short Report