Interaction of SARS-CoV-2 with cardiomyocytes: Insight into the underlying molecular mechanisms of cardiac injury and pharmacotherapySARS-CoV-2와 심근세포의 상호작용: 심장 손상 및 약물 요법의 기본 분자 메커니즘에 대한 통찰력Review Published on 2022-02-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 치료제, [키워드] Abnormalities accessory protein accessory proteins ACE2 adopted advent arteries blood cell calcium cardiac cardiac disease cardiac injuries cardiomyocyte cause CD147 circulating complications Coronary arteries COVID-19 COVID-19 patient dysfunction electrical exhibited Express Extracellular vesicles facilitate heart help homeostasis Infection Injury insight integrin Interaction involved Lungs Manifestations manifested mechanism molecular mechanism pathway Pathways pericyte pericytes pharmacotherapy PROTECT Protein receptor reduced Respiratory illness ROS production SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles SARS-CoV-2 vaccines severe COVID-19 Side effect Side effects signaling pathway Spectrum subject Support the SARS-CoV-2 TMPRSS2 Treatment Vaccine virus [DOI] 10.1016/j.biopha.2021.112518 PMC 바로가기 [Article Type] Review
NK cell dysfunction in severe COVID-19: TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicityResearch Highlight Published on 2022-01-312022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, Fulltext, SARS, [키워드] cytotoxicity downregulation dysfunction Infectious diseases Innate immunity integrin NK cell restrict [DOI] 10.1038/s41392-022-00892-5 PMC 바로가기 [Article Type] Research Highlight
Where the Action Is—Leukocyte Recruitment in AtherosclerosisArticle Published on 2022-01-112023-08-30 Journal: Frontiers in Cardiovascular Medicine [Category] E형 간염, [키워드] adhesion molecules Atherosclerosis integrin leukocyte recruitment transendothelial migration vascular inflammation [DOI] 10.3389/fcvm.2021.813984 PMC 바로가기
Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for PathogenicityArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 air–liquid interface Alpha Altered alveolar Analysis anti-viral response bronchial bronchial epithelial cell canonical cell membrane coronavirus COVID-19 COVID-19 vaccines cytokine differentially regulated gene Effect enzyme exposure to expression fibrosis host cell receptor Human IFN IFNγ IL10 IL12 IL13 IL2 IL4 IL6 IL8 Infection Influenza integrin interferon Ligand lung Lung fibrosis MERS (middle east respiratory syndrome) mRNA-based mucosa Mutation Necrosis neutralizing antibody p53 pathogenicity pathway platform pro-fibrotic pro-inflammatory cytokine pulmonary receptor Receptor binding domain Recombinant S1 protein regions robust S1 protein S1 subunit SARS (severe acute respiratory syndrome) SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant secreted Signaling significantly spike spike glycoprotein Spike protein the S1 subunit TLR TLR4 Type II pneumocyte virus [DOI] 10.3390/v13122537 PMC 바로가기 [Article Type] Article
Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based IsolationReview Published on 2021-11-262022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] adhesion Affect affecting Anti-inflammatory anticancer Biomolecule biosensors CAM can be used Cell Cell adhesion cellular classical Compound concerning Effect Effects Evidence experiment faster fungi Gene Expression greater Health highlighting integrin Isolation knowledge mechanism metabolite metabolites Migration movement natural natural compound plant plants preparation quantification SARS-CoV-2 SARS-CoV-2 treatment signaling pathway Stimulation surface receptor target viability virus [DOI] 10.3390/biomedicines9121781 PMC 바로가기 [Article Type] Review
Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?Cellular and Infection Microbiology Published on 2021-11-182022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] ACE2 analyzed angiotensin-converting enzyme 2 Betacoronavirus betacoronaviruses bind binding bioinformatics Can canonical changes in collected Computational study conformational change conserved coronavirus 2 coronavirus strains domain ENhance entry receptor explain expression Factor help Host host cell identify independent independent of integrin integrin-binding motif Integrins ligands mapped motif motifs Mutation occur Other phylogenetically predicted RaTG13 recent recorded Region RGD rotaviruses SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein sequence sequence similarity shown solvent spike Spike protein Spike proteins spike receptor-binding domain suggested the SARS-CoV-2 the spike protein viral pathogens virus [DOI] 10.3389/fcimb.2021.765300 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Platelet Phenotype Analysis of COVID-19 Patients Reveals Progressive Changes in the Activation of Integrin αIIbβ3, F13A1, the SARS-CoV-2 Target EIF4A1 and Annexin A5Cardiovascular Medicine Published on 2021-11-112022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Activation acute respiratory syndrome alteration Analysis Annexin annexin A5 Antiphospholipid syndrome ANXA5 autoantigen biochemical caused change Coagulation coagulation factor XIII (FXIII, F13A1) consequence Consumption coronavirus correlated COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients decrease determine EIF4A1 eukaryotic eukaryotic initiation factor (EIF4A1) examined F13A1 Final flow cytometry functional healthy control healthy controls; healthy subjects Hospital stay Hospitalization Infection integrin integrin αIIbβ3 ITGA2B Mortality nasopharyngeal viral load Non-survivors observation period outcome over P4HB pathogenesis of COVID-19 patients with COVID-19 PDIA6 phenotype plasma concentration Platelet Platelets Progressive Protein proteome proteomic severe pneumonia significant changes in significantly subunit Support Survivors syndrome TALDO1 target the SARS-CoV-2 thrombosis two-dimensional virus replication [DOI] 10.3389/fcvm.2021.779073 PMC 바로가기 [Article Type] Cardiovascular Medicine
Integrin activation is an essential component of SARS-CoV-2 infection인테그린 활성화는 SARS-COV-2 감염의 필수 구성 요소입니다Article Published on 2021-10-142022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 Activation angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antagonist basal state bind binding Cell adhesion Cell Biology cell entry confocal microscopy cytoplasmic tail Diseases downstream engage Engagement ENhance enzyme expresse extension flow cytometry inactive induce Infection Infectious diseases inhibit inhibited integrin Integrins ligands macromolecular mechanism membrane motif occur Particle peptide Peptide inhibitor Protein receptors rhodamine rhodamine B S protein SARS-CoV-2 SARS-COV-2 infection Signaling subunit viral infection [DOI] 10.1038/s41598-021-99893-7 PMC 바로가기 [Article Type] Article
Emerging therapeutic opportunities for integrin inhibitors Reviews Published on 2021-09-172022-10-05 Journal: Nature Reviews Drug Discovery [Category] 바이오마커, [키워드] Biological functions bowel Cancer cardiovascular diseases Cell clinical development clinical trials clinically disease Diseases drug Drug discovery Inflammatory inhibitor integrin Integrins investigated New Osteoporosis pharmacological Protein pulmonary fibrosis Research review steatohepatitis therapeutic Treatment [DOI] 10.1038/s41573-021-00284-4 [Article Type] Reviews
Role of Peptides in Diagnostics진단에서 펩티드의 역할Review Published on 2021-08-172022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] Analysis Antigen applicability biofluids Blood Cancer Chemokine receptor clearance Computed tomography COVID-19 diagnostic diagnostics disease Diseases ELISA enzyme enzyme-linked immunosorbent assay evaluated gastrin Gastrin-releasing peptide imaging diagnostic immunogenicity information integrin interleukin interleukin 2 Lateral flow device low molecular weight membrane Microarray molecular molecular imaging molecular weight non-imaging diagnostic penetration peptide peptide-based peptides pet platform point-of-care positron emission Positron emission tomography probe probes Prostate purity radiolabeled receptor Receptor imaging receptors role single-photon emission computed tomography Somatostatin specificity SPECT stability synthetic peptide synthetic peptides tissue tomography [DOI] 10.3390/ijms22168828 PMC 바로가기 [Article Type] Review