In silico screening of potent inhibitors against COVID-19 key targets from a library of FDA-approved drugsFDA 승인 약물 라이브러리에서 Covid-19 핵심 목표에 대한 강력한 억제제의 실리코 스크리닝에서Article Published on 2022-02-012022-08-31 Journal: Environmental science and pollution research inter [Category] COVID19(2023년), MERS, SARS, 신약개발, 치료제, [키워드] Analysis angiotensin Angiotensin II Angiotensin receptor blockers Antibiotics antihypertensive approval assigned binding blocker Cell coronavirus coronavirus disease COVID-19 development disease drug Drug repurposing Efficacy exhibited FDA-approved drug FDA-approved drugs Heartburn inhibitor Interference library life cycle molecular docking molecular target oral Oral antiseptics. OTC Other pandemic pathway Polymyxin B Protein receptor rifampicin screened severity of COVID-19 specific proteins stability Stage target target protein target proteins tested therapeutic therapeutic purpose Vaccine virus Virus life cycle [DOI] 10.1007/s11356-021-16427-4 PMC 바로가기 [Article Type] Article
Interference of D-dimer levels from heterophilic antibody in COVID-19: A serious concern in treatment and follow-up of patientsCOVID-19에서 이종성 항체의 D-dimer 수준 간섭: 환자의 치료 및 후속 조치에 대한 심각한 우려Case Reports Published on 2022-02-012022-09-12 Journal: International journal of laboratory hematology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Abstract antibodies antibody Coagulation COVID-19 D-dimer D-dimer level Follow-up heterophilic antibodies. Interference Patient Treatment [DOI] 10.1111/ijlh.13654 PMC 바로가기 [Article Type] Case Reports
Stressors faced by healthcare professionals and coping strategies during the early stage of the COVID-19 pandemic in Germany독일의 Covid-19 Pandemic의 초기 단계에서 의료 전문가와 대처 전략이 직면 한 스트레스 요인Observational Study Published on 2022-01-182022-09-10 Journal: PLoS ONE [Category] SARS, 임상, 치료기술, [키워드] Asia average benefit buffer calmness capture Care coded concerning conducted Contact coping strategies Coping strategy country COVID-19 pandemic cross-sectional demonstrated detect early stage EFA Effect effective effective coping Effects Emergency Care examined exchange facilitate Factor Factor analysis Families fatigue friends Future Germany health systems healthcare Healthcare professional healthcare professionals Healthcare system Healthcare systems healthcare worker Healthcare workers hospital identify Interference International knowledge longitudinal design male Masks measure Measures medical staff moderate mood National pandemic Pandemics Patient Perceived stress prehospital emergency care professional Psychological psychological Impact Psychological stress question reduced Regulation reported resource response responses Result schedule SEM significantly significantly higher social distancing Social support Stress stress level Stressor stressors Support team utilization with COVID-19 workload Workplace [DOI] 10.1371/journal.pone.0261502 PMC 바로가기 [Article Type] Observational Study
Striking a Balance between Work and Play: The Effects of Work–Life Interference and Burnout on Faculty Turnover Intentions and Career SatisfactionArticle Published on 2022-01-122022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] Administered balance Burnout Canada career career satisfaction collected contribute COVID-19 cross-sectional design decrease Descriptive statistics driver Effect Emotional exhaustion estimate faculty faculty shortage highlighting IMPROVE increase Intention Interaction Interference Intervention National Nursing nursing faculty physical Predictive psychological health Qualtrics reduce reliability risk Satisfaction shown significantly turn turnover turnover intentions was tested was used work Work environment work–life interference [DOI] 10.3390/ijerph19020809 PMC 바로가기 [Article Type] Article
Analytical and Clinical Evaluation of the Semiquantitative Elecsys Anti-SARS-CoV-2 Spike Protein Receptor Binding Domain Antibody Assay on the Roche cobas e602 AnalyzerRoche cobas e602 분석기에서 반정량적 Elecsys Anti-SARS-CoV-2 스파이크 단백질 수용체 결합 도메인 항체 분석의 분석 및 임상 평가Article Published on 2022-01-062022-09-11 Journal: American journal of clinical pathology [Category] SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analyzer Anti-spike anti-spike antibodies antibodies antibody Bilirubin Biotin clinical clinically Concordance coronavirus COVID-19 COVID-19 patient COVID-19 vaccination cross-reactivity detect diagnostics Elecsy ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluate evaluated exhibit greater hemoglobin IgA antibodies IgA antibody IgG IgM immunoassay Interference Lateral flow device linearity measure mRNA Neutralization assay PCR positivity plasma Precision Protein Receptor binding domain respiratory robust Roche SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus Semiquantitative semiquantitatively Sensitivity and specificity serology Seropositivity serum spike Spike protein triglycerides turn [DOI] 10.1093/ajcp/aqab092 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Protein Destabilizes Microvascular HomeostasisSARS-CoV-2 스파이크 단백질은 미세혈관 항상성을 불안정하게 합니다.Research Article Published on 2021-12-222022-09-10 Journal: Microbiology Spectrum [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 ACE2 expression Activation adverse effect adverse effects Affect alveolar alveolar epithelial cell Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin II Apoptosis Aspirin bind blunt bradykinin calcium Calcium signaling caspase cause caused Cell Cell signaling cells Coagulopathies complex Concentration contribute contributing to COVID-19 COVID-19 disease decreased expression downregulation dysfunction Effect Endothelial cell endothelial cells Endothelial dysfunction enzymatic activity enzyme epithelial epithelial cells event Evidence exposure expressed Factor homeostasis immunofluorescence microscopy in vitro model increased expression indicated infects Inflammation Interaction Interference Intervention Krüppel limit lung lung tissue lung tissues Lungs mechanism molecules organ dysfunction Pathogenesis pathology primary human cells pro-inflammatory molecules rationale receptor reduce reduced Respiratory function SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection Signaling significantly spike Spike protein suggested tested these cell These cells thought thrombotic Thrombotic events understanding uninfected Vascular viability [DOI] 10.1128/Spectrum.00735-21 PMC 바로가기 [Article Type] Research Article
Targeting CK2 mediated signaling to impair/tackle SARS-CoV-2 infection: a computational biology approachSARS-CoV-2 감염을 손상/퇴치하기 위한 CK2 매개 신호 표적화: 컴퓨터 생물학 접근Research Article Published on 2021-12-202022-09-10 Journal: Molecular Medicine [Category] SARS, 신약개발, 유전자 메커니즘, [키워드] Analysis antagonist antagonistic effect anticancer antiviral activity antiviral responses approach attenuation bind bleeding Cancer cancer treatment Cell CIGB-300 CK2 inhibitor Coagulation Combination computational analysis Computational biology coronavirus drug Drug repurposing early stage early stages Evidence evidence of Functional enrichment analyses Functional enrichment analysis HSBP1 human cells immune response incidence infected with SARS-CoV-2 inhibitor interfere Interference life cycle mechanism molecular molecular mechanism muscle NPM1/B23 peptide phenotype Phenotypes Phosphoproteomics Phosphorylation predict predicted provide provided recent respiratory respiratory disorders responsible Result RNA splicing SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle Signaling SQSTM1 SRSF1 supplementary material Support targeting the SARS-CoV-2 treat Viral viral infection viral infections virus Virus-host interaction Virus-host interactions was used [DOI] 10.1186/s10020-021-00424-x PMC 바로가기 [Article Type] Research Article
A high-throughput pipeline for scalable kit-free RNA extraction확장 가능한 키트가없는 RNA 추출을위한 고 처리량 파이프 라인Article Published on 2021-12-012022-09-01 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] Accuracy acquisition added approach Assay systems Automation clinical diagnose clinical diagnoses diagnose diagnostic diagnostic sensitivity downstream High-throughput screening Infectious disease Infectious-disease diagnostics Interference Laboratory techniques and procedures miniaturization molecular offer protocol RNA RNA extraction robust RT-qPCR SARS-CoV-2 detection sensitivity Supply chain Volume volume acquisition [DOI] 10.1038/s41598-021-02742-w PMC 바로가기 [Article Type] Article
Evaluation of the clinical and analytical performance of the Seegene allplex™ SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI)관심 변이체(VOC) 및 관심 변이체(VOI) 검출을 위한 Seegene allplex™ SARS-CoV-2 변이체 I 분석의 임상 및 분석 성능 평가Article Published on 2021-11-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 변종, 치료기술, [키워드] 95% CI calculated clinical study Clinical use COVID-19 cross-reactivity demonstrated detect diagnostic E484K mutation evaluated gargle genotyping Interference limit of detection microorganism microorganisms Mutation N501Y nasopharyngeal NP swab positive reference standard reproducibility RT-PCR S gene SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing specificity specimen specimens stability Swab variant variant of concern (VOC) Variant of interest (VOI) variants of concern variants of interest VoC WGS whole genome Whole genome sequencing [DOI] 10.1016/j.jcv.2021.104996 PMC 바로가기 [Article Type] Article
Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamstersSARS-CoV-2와 인플루엔자 바이러스의 동시 감염은 햄스터에서 더 심각하고 장기적인 폐렴을 유발합니다Article Published on 2021-10-282022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjacent area body weight Body weight loss cause caused Cell cell tropism Co-infection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms fatality growth hamster hamsters Health IAV IL-6 immunohistochemical analyses in vivo Infection Infectious diseases Influenza influenza A influenza A virus Influenza virus inhibit Interference involved lung Lungs organ organs pathogen Pathogens Pneumonia Post-infection public health respiratory risk SARS-CoV-2 SARS-CoV-2-infected hamsters sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity severity of COVID-19 significant increase Spread Symptom Virology virus viruses weight loss [DOI] 10.1038/s41598-021-00809-2 PMC 바로가기 [Article Type] Article