Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signalingLetter to the Editor Published on 2021-10-232022-10-30 Journal: Journal of Molecular Cell Biology [Category] COVID-19, SARS, [키워드] Host Interaction interactome interferon signaling reveal SARS-CoV-2 nsp13 Stat1 suppress [DOI] 10.1093/jmcb/mjab068 PMC 바로가기 [Article Type] Letter to the Editor
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation17개의 SARS-CoV-2 단백질의 근위 프로테옴은 항바이러스 신호 전달 및 숙주 번역을 방해합니다.Research Article Published on 2021-10-012022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] Activation antiviral signaling association atlas Card cleavage complex coronavirus Coronaviruses COVID-19 severity CWC22 database Factor FANCD2 Fluorescence functional Host host protein host proteins human cell human protein identify IFNB1 Impact inhibited inhibitor innate immune interferon signaling M protein MAVS membranes nsp1 nsp5 ORF6 Pathogenesis pathogenic coronavirus pathogenic mechanism pathogenic mechanisms pathogenicity peptide peptide sequences promote promoter protease Protein protein translation Proteins proteome proteomics proximal public health threat regulator Regulatory resource RIG-I SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral sequence Signaling subcellular target the SARS-CoV-2 translation translation initiation Transport TRIM4 variant Viral Viral protein Viral proteins [DOI] 10.1371/journal.ppat.1009412 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT PathwaySARS-CoV-2는 JAK-STAT 경로에서 근위 요소를 방해합니다Article Published on 2021-09-092022-09-11 Journal: Journal of Virology [Category] Coronavirus, SARS, 유전자 메커니즘, 진단, [키워드] affected Analysis Antiviral benefit Brain Cell cell type cell types cellular cellular processe cellular processes components Culture culture systems cultures defined destabilize element evade heart help human body human cell human cell line human cell lines identify IFN IFN antagonism IFN signaling IFNAR1 immortalized immune immune evasion infect infected cell infected cells Infection inhibiting innate immune response Innate immunity interferon interferon receptor interferon signaling intestine Jak Jak-STAT JAK-STAT pathway JAK1 Janus kinase Janus kinase 1 kidney kinase kinases liver lung mechanism mediators molecular multiple organs organ pathway Pathways patients with COVID-19 performed Protein proteomics proximal receptor Replication representing resulting SARS-CoV-2 SARS-COV-2 infection STAT subunit suppression systematic analysis target the interferon these cell These cells tissue TYK2 Type I IFN type I interferon tyrosine Viral virus virus replication Virus-host interactions [DOI] 10.1128/JVI.00862-21 PMC 바로가기 [Article Type] Article
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cellsResource and Technical Advance Published on 2021-08-232022-10-30 Journal: JCI Insight [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression AIDS/HIV analyzed antiviral genes antiviral response canonical cause change chronic controls COVID-19 disease severity downregulation Enterocyte epithelial cell expression fatality GI Tract Gut highest HIV infection homeostasis impair increased risk individual individuals infect Innate immunity interferon response interferon signaling intestinal lymphoid mucosal Prevent Protein reduction SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 receptor single-cell small intestine Symptoms target cell target cells tissue TMPRSS2 TMPRSS4 transcriptional profile treated uninfected upregulation vaccine response [DOI] 10.1172/jci.insight.148920 PMC 바로가기 [Article Type] Resource and Technical Advance
HBV-Specific CD8+ T-Cell Tolerance in the LiverArticle Published on 2021-08-062023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] co-inhibitory signaling Hepatitis B virus interferon signaling intrahepatic antigen recognition liver tolerance Metabolic regulation T cell exhaustion [DOI] 10.3389/fimmu.2021.721975 PMC 바로가기
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signalingResearch Article Published on 2021-08-042022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] Activation ADP-ribosylation Antiviral binding can be used cascade catalyzed cellular coronavirus coronavirus pathogenesis COVID-19 dependent on downstream DTX3L ectopic expression expression Genes Host host protein human cells IFN IFN response IFN signaling IFN, interferon impair induce inhibitors interferon interferon signaling ISG, Interferon-stimulated gene macrodomain Modification nonstructural protein 3 Nsp3, nonstructural protein 3 PARP, poly(ADP-ribose) polymerase PARP9 PARPs polymerase Protein robust SARS-CoV-2 suppress target the SARS-CoV-2 thought [DOI] 10.1016/j.jbc.2021.101041 PMC 바로가기 [Article Type] Research Article
Lack of active SARS-CoV-2 virus in a subset of PCR-positive COVID-19 congregate care patientsPCR 양성 COVID-19 집단 치료 환자의 하위 집합에서 활성 SARS-CoV-2 바이러스 부족Article Published on 2021-08-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 치료기술, [키워드] Accuracy antibody Antibody titer Care collected correlated COVID-19 Culture cultures detect diagnosis of COVID-19 disease genomic incidence interferon interferon signaling log NAAT Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples non-infectious not affect nucleic acid nucleic acid amplification nucleic acid amplification tests occurred pathway Patient patients PCR-positive plaque Plaque assay plaque-forming unit positive qPCR quantitation RNA fragment RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 virus signaling pathway Stage Standard of care Stat1 Sub-genomic RNA subset symptom onset tested Vero Vero E6 Vero E6 cell VERO E6 cells Vero STAT1(−/−). Viral RNA viral RNA load virus [DOI] 10.1016/j.jcv.2021.104879 PMC 바로가기 [Article Type] Article
COVID-19 in Patients Receiving CD20-depleting Immunochemotherapy for B-cell Lymphoma002 Published on 2021-07-282022-10-31 Journal: HemaSphere [Category] COVID-19, [키워드] Activation age analyses Analysis Anti-CD20 antibody B-cell biospecimens CD4 CD8 Cell cellular and molecular Chemotherapy Clinical course Clinical deterioration clinically Cohort colony stimulating factor complement conducted coronavirus disease COVID-19 COVID-19 in patient depleting functional Gene expression analysis granulocyte had more Hospitalization Hospitalized hyperinflammation ICU Immune cell immune profiling Immunochemotherapy immunological In vitro assay Inflammatory response interferon signaling longitudinal lymphoma lymphomas mechanical ventilation median monocytes/macrophages mononuclear cell Neutrophils Patient patients performed Peripheral blood receiving required respiratory specimen responses SARS-CoV-2 SARS-CoV-2 antibody response subsequent Support virological study [DOI] 10.1097/HS9.0000000000000603 PMC 바로가기 [Article Type] 002
ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactionsResearch Article Published on 2021-07-022022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] ACE2 analyses Analysis can be used Cell cell line COVID-19 COVID-19 patients COVID-19 research driving explain Express H353K hACE2 histological human ACE2 identify IFNAR in vitro in vivo infect infect cells Infection inflammatory disease Inflammatory response Inflammatory responses Interaction interferon response interferon signaling involved key amino acid lung lung epithelium mACE2 mice Mutagenesis no significant effect receptor Replication required rescued SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 research substitutions Support tissue repair transcriptomic profile transduction type I utility Vaccine Vaccines virus virus replication was used were used [DOI] 10.1371/journal.ppat.1009723 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epitheliumSARS-CoV-2는 인간 성인 기증자의 눈과 hESC 유래 안구 상피를 감염시킵니다.Article Published on 2021-07-012022-09-11 Journal: Cell Stem Cell [Category] SARS, 치료기술, [키워드] ACE2 aerosol transmission Analysis antigen expression cadaver caused Cell Cornea COVID-19 COVID-19 patient Culture Donor Ex vivo eye infect infected cell infected cells Infection interferon interferon signaling life limbus mechanism NF-κB ocular Ocular surface organoid cultures portal Post-mortem productive viral replication regions robust SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 pandemic scRNA-seq Spread stem cells These data thought tissue Transmission viral entry viral particle Viral particles while [DOI] 10.1016/j.stem.2021.04.028 PMC 바로가기 [Article Type] Article