Risks of SARS-CoV-2 Infection and Immune Response to COVID-19 Vaccines in Patients With Inflammatory Bowel Disease: Current Evidence염증성 장 질환 환자의 코로나19 백신에 대한 SARS-CoV-2 감염 및 면역 반응의 위험: 현재 증거Review Published on 2022-06-232022-09-11 Journal: Frontiers in Immunology [Category] 변종, [키워드] aberrant immune response Affect available data bowel Combination condition Corticosteroid Corticosteroids Course COVID-19 COVID-19 vaccine COVID-19 vaccines Crohn's disease Crohn’s disease current disease dysregulated environmental factors Factor forms healthy subjects IBD immune immune response immunogenicity Immunosuppressant immunosuppressants increased risk infection with SARS-CoV-2 infections Inflammatory Inflammatory bowel disease inflammatory bowel diseases intestinal intestinal disease less majority many case many cases measure modify Necrosis occur pandemic Pathogens Patient patients treated PROTECT Psychological psychological factors question receive reduce reduced response risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants significantly increased subject susceptibility susceptibility to infection susceptible individual therapy ulcerative colitis Vaccine [DOI] 10.3389/fimmu.2022.933774 PMC 바로가기 [Article Type] Review
Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation Research Published on 2022-06-222022-10-05 Journal: Acta pharmacologica Sinica [Category] 바이오마커, [키워드] activated Activation addition administration ameliorated Analysis Anti-inflammatory Apoptosis Caco-2 cells Cell cell proliferation Colitis Colon colonic comparable degranulation down-regulated downstream gene downstream signaling pathways epithelial expression in vitro in vivo inactivation Inflammation inhibited inhibiting injection intestinal intestinal inflammation investigated involved MAPK mechanism neutrophil neutrophil degranulation neutrophil recruitment NF-κB prevented pro-inflammatory cytokine promoted Protein Proteins proteomic recruitment regulated restored S100A9 signaling pathway significantly suppressed therapeutic therapeutic effect TLR4 [DOI] 10.1038/s41401-022-00933-3 [Article Type] Research
Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infectionSARS-CoV-2 RNA의 위장 증상 및 배설물 배출은 장기간의 위장 감염을 시사합니다Article Published on 2022-06-102022-09-11 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), SARS, 임상, 진단, 치료기술, [키워드] abdominal pain analyzed association confidence interval correlated COVID-19 COVID-19 diagnosis Diagnosis disease symptoms fecal fecal RNA fecal samples feces Gastrointestinal Gastrointestinal infection GI symptom GI symptoms GI Tract individual individuals with COVID-19 infect Infection intestinal lung Mild mild to moderate mild to moderate disease moderate disease nausea NIH Oropharyngeal participant Research Respiratory samples RNA SARS-CoV-2 SARS-CoV-2 RNA Stanford subject subset supported Symptom Symptoms viral replication Viral RNA Viral RNA shedding viral shedding vomiting [DOI] 10.1016/j.medj.2022.04.001 PMC 바로가기 [Article Type] Article
Persistence of Anti SARS-CoV-2 Antibodies in Breast Milk from Infected and Vaccinated Women after In Vitro-Simulated Gastrointestinal Digestion체외 모의 위장 소화 후 감염 및 백신 접종 여성의 모유 내 항 SARS-CoV-2 항체 지속성Article Published on 2022-05-192022-09-12 Journal: Nutrients [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 antibodies antibody approach BNT162b2 mRNA Breast breast milk Breastfeeding colonic colonic fermentation Compound control group COVID-19 cut-off value demonstrated digested digestion ELISA expected fecal Gastrointestinal gastrointestinal tract group growth Gut gut microbiota IgA IgG IgG antibody immunization in vitro in vitro digestion Infant Infection intestinal lactating women lactation lactation. microbial microbiota milk mRNA vaccination mRNA-1273 no effect pathway persistence positive qPCR receiving recent reduced remained SARS-CoV-2 SARS-CoV-2 antibody significantly Specific stages tested the antibody the study group vaccination virus was determined was tested women [DOI] 10.3390/nu14102117 PMC 바로가기 [Article Type] Article
Obstructive Sleep Apnea as a Risk Factor for COVID-19 Severity-The Gut Microbiome as a Common Player Mediating Systemic Inflammation via Gut Barrier DysfunctionCOVID-19 심각도의 위험 인자로서의 폐쇄성 수면 무호흡증 - 장 장벽 기능 장애를 통해 전신 염증을 매개하는 일반적인 플레이어로서의 장내 미생물군집Review Published on 2022-05-062022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome adjuvant therapy age Bacterial bacterial translocation barrier Biomarker Biomarkers clinical outcomes common conducted conjunction contribute COVID-19 COVID-19 severity death diabetes Diabetes Mellitus disease dysfunction elements evaluate Factor foster Gut gut microbiome gut microbiota hypertension hypoxia independent risk factor Inflammation interactions intermittent hypoxia intestinal intestinal permeability literature review Mediating mild respiratory symptom mild respiratory symptoms novel corona virus obesity Obstructive obstructive sleep apnea OSA outcome raise respiratory distress risk risk factor SARS-CoV-2 severity of COVID-19 shift shown Sleep sleep apnea syndrome systemic systemic inflammation therapy tight junction translocation triangular zonulin [DOI] 10.3390/cells11091569 PMC 바로가기 [Article Type] Review
Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19SARS-CoV-2에 감염된 Caco-2 장 세포에서 CDH1/E-Cadherin 유전자 발현 및 가용성 형태의 E-Cadherin 방출 제어: COVID-19의 장 형태에 대한 생리병리학적 결과Article Published on 2022-05-042022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] 24 hour 24 hours 48 hour 48 hours ACE2 ACE2 mRNA Affect AT1 Caco-2 Caco-2 cell Caco-2 cells cadherin CDH1 Cell cell line cells Co-receptor connexin consequence contributing to Control COVID-19 Culture culture supernatant diarrhoea diarrhoea) digestive tract Disruption dissemination down-regulated dysregulation E-cadherin ENCODE epithelial exposure to expresse expression form Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract HCoV HCoV-OC43 HLA class I human ACE2 illnesses in viral induce infected with SARS-CoV-2 Infection intestinal Intestinal barrier intestinal cells intestinal tissue intranasal involved JAMA junctions leads membrane mRNA mRNA expression OC43 occludin pandemic Patient Physiopathological Post-infection Protein receptor receptor ACE2 Release remained reported respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection significant increase significantly lower Symptom the disease these symptoms TMPRSS2 Transcription transgenic mice Trigger Viral viral entry virus [DOI] 10.3389/fcimb.2022.798767 PMC 바로가기 [Article Type] Article
Mapping the epithelial–immune cell interactome upon infection in the gut and the upper airways Research Published on 2022-05-022022-10-05 Journal: NPJ Systems Biology and Applications [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] airway Alter approach Cell cell interaction Ciliated epithelial cells colonic complex disease driving epithelial epithelial cell Evidence experimental analysis Gut ileal immune cell populations immune response Impact Increasing Infection Inflammation Inflammatory responses Interaction intercellular intestinal Local mapping methodology molecular target Organoid SARS-CoV-2 SARS-COV-2 infection single-cell RNA-seq systemic immune response upper airway viral infection [DOI] 10.1038/s41540-022-00224-x [Article Type] Research
Fulminant necrotizing amoebic colitis presenting as acute appendicitis: a case report and comprehensive literature review급성 충수염으로 나타난 급성 괴사성 아메바 대장염: 사례 보고 및 포괄적 문헌 검토Article Published on 2022-04-302024-08-22 Journal: J Infect Dev Ctries [Category] 세균성이질, [키워드] Amoebiasis Indonesia intestinal metronidazole Necrosis
Stop of proton-pump inhibitor treatment in patients with liver cirrhosis (STOPPIT): study protocol for a prospective, multicentre, controlled, randomized, double-blind trial간경변 환자에서 양성자 펌프 억제제 치료 중단(STOPPIT): 전향적, 다기관, 대조, 무작위, 이중 맹검 시험을 위한 연구 프로토콜Article Published on 2022-04-122022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 bleeding bleeding event cirrhosis clinical Clinical outcome clinical outcomes clinical trial complications composite endpoint control group death defined Diagnosis double-blind trial double-blinded Effect Endpoint Esomeprazole EU Clinical Trials EudraCT evaluate excluded gastritis gastrointestinal bleeding Germany Hemorrhagic hepatic Hepatic encephalopathy Hospitalization Hospitalized Hypothesis IMPROVE include increased risk indication infections Infectious complications inhibitor intervention group intestinal liberal liver Liver cirrhosis liver failure manifestation medication microbiota Mortality multicentre observational studies observational study Occurrence outcome Pantoprazole parallel-group Patient peptic ulcer Placebo placebo-controlled PPI primary composite endpoint Prophylactic Proton-pump inhibitors Randomized rationale receive recruitment reflux esophagitis Registered risk secondary Secondary endpoints Side-effects STOP Study protocol therapy Treatment Trial variable Withdrawal [DOI] 10.1186/s13063-022-06232-w PMC 바로가기 [Article Type] Article
Differences in SARS-CoV-2 Vaccine Response Dynamics Between Class-I- and Class-II-Specific T-Cell Receptors in Inflammatory Bowel Disease염증성 장 질환에서 클래스 I 및 클래스 II 특정 T 세포 수용체 간의 SARS-CoV-2 백신 반응 역학의 차이Article Published on 2022-04-082022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Ad26 Ad26.COV2.S Adaptive immune response adaptive immune responses age analyzed antibody antibody levels Antigen antigens BNT162b2 booster bowel characterized clone clones Cohort conditions Critical deficiencies deficiency difference Dynamics expansion Factor HCWs Health care Health care worker health care workers IBD immune factors immune response immune responses Immune-mediated immunodeficiency immunomodulatory induce Infection Inflammatory Inflammatory bowel disease inflammatory disease Inflammatory diseases intestinal mechanism molecular mRNA mRNA vaccine mRNA-1273 vaccine Patient patients protocols response responses robust SARS-CoV-2 SARS-CoV-2 (COVID-19) SARS-CoV-2 vaccination sequenced Sequencing significant difference significant differences Spectrum stratified subset T-cell T-cell receptor T-cell repertoire T-cell Response T-cell responses T-cells TCR the patient Treatment understanding vaccination vaccination response vaccination schedule Vaccine [DOI] 10.3389/fimmu.2022.880190 PMC 바로가기 [Article Type] Article