Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19아미노산 감지 경로: 비만과 코로나19 발병의 주요 체크포인트Review Published on 2021-04-012022-09-11 Journal: Obesity Reviews [Category] SARS, 유전자 메커니즘, [키워드] Activation aggravate Amino acid amino acid sensor GCN2 amino acids antiviral response Comorbidities Comorbidity correlation COVID-19 COVID-19 susceptibility deficiency effective GCN2 Host host cell host cells Hyperactivation IL-1β increase Infection Inflammation inhibiting interleukin interleukin-1 beta intestinal inflammation mammalian mechanism mitigate Mortality mTOR obesity obesogenic opposite overnutrition oxygen Pathogenesis Pathologies pathway pro-inflammatory cytokine Rapamycin reactive oxygen species reactive oxygen specy Replication reprogramming ROS SARS-CoV-2 serum shown suppresse susceptibility translation translational viral infections Viremia while with COVID-19 [DOI] 10.1111/obr.13221 PMC 바로가기 [Article Type] Review
The faecal metabolome in COVID-19 patients is altered and associated with clinical features and gut microbesCOVID-19 환자의 대변 대사체가 변경되어 임상 특징 및 장내 미생물과 관련이 있습니다.Article Published on 2021-04-012022-09-11 Journal: Analytica chimica acta [Category] SARS, 치료기술, [키워드] absorbed Absorption Actinomyces age alteration analysed Analysis Aspergillus behenic acid butylphenol can not clinical feature Clinical features clinical information Cohort collected component Compound conducted correlated correlation COVID-19 COVID-19 patient COVID-19 patients D-pinitol digestion discharge discharged patient discharged patients faece Faeces fatty gas chromatography Gas Chromatography-Mass Spectrometry glycerol greater Gut HCs healthy control healthy controls healthy subject hospital humans hypoxanthine intestinal inflammation intestine Malnutrition mass spectrometry metabolite metabolites metabolome microbe microbiota Mycobiota not different oxalate Pathogenesis pinitol purine SARS-CoV-2 serum significantly Spearman sucrose the patient Treatment treatment of COVID-19 validation cohort [DOI] 10.1016/j.aca.2021.338267 PMC 바로가기 [Article Type] Article
Intestinal Receptor of SARS-CoV-2 in Inflamed IBD Tissue Seems Downregulated by HNF4A in Ileum and Upregulated by Interferon Regulating Factors in Colon염증이 있는 IBD 조직에서 SARS-CoV-2의 장 수용체는 회장에서 HNF4A에 의해 하향 조절되고 결장에서 인터페론 조절 인자에 의해 상향 조절되는 것으로 보입니다Article Published on 2021-03-052022-09-11 Journal: Journal of Crohn's & colitis [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression Alter analysed Analysis anti-TNF biopsy bowel Co-expression analysis collected Colon colonic Control COVID-19 Crohn's disease Cytokines Differential gene expression disease dysregulation entry mechanisms epithelial Factor HNF4A IBD IBD susceptibility gene ileal ileum Immunosuppressed inflamed CD ileum Inflammation Inflammatory Inflammatory bowel disease inflammatory bowel diseases inflammatory stimuli interferon intestinal intestinal inflammation intestine investigated Microarray Microarrays mucosal Necrosis network Organoid organoids Patient patients pro-inflammatory cytokine pro-inflammatory cytokines processed Prognosis regulated Regulating Regulation responders restored risk factor RNA sequencing SARS-CoV-2 SARS-COV-2 infection Sequencing sequencing data shown significantly Single Cell single-cell therapy tissue TMPRSS2 transcriptomics ulcerative colitis upregulated upstream [DOI] 10.1093/ecco-jcc/jjaa185 PMC 바로가기 [Article Type] Article
Breastfeeding importance and its therapeutic potential against SARS‐CoV‐2Short Review Published on 2021-02-132022-10-28 Journal: Physiological Reports [Category] COVID-19, MERS, [키워드] ACE2 affecting bind Breastfeeding breastmilk Caseins Cell cell membrane cell types ciliated cell colostrum component coronavirus COVID‐19 decrease diarrhea disease symptoms disorder Effect element Enterocyte enzyme expressed growth factor Gut highly active Host immunostimulatory impair incidence include Infant Infants Inflammation intestinal inflammation intestine lung maintain metabolism milk mucins mucosa Newborn Novel coronavirus organism postnatal development processed PROTECT Protein Proteins Replication Respiratory disease respiratory tract response SARS SARS‐CoV‐2 SARS‐CoV‐2 infection secretory immunoglobulin A Serotonin therapeutic potential virus [DOI] 10.14814/phy2.14744 PMC 바로가기 [Article Type] Short Review
Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2-related Disease장 염증은 ACE2 및 TMPRSS2의 발현을 조절하고 SARS-CoV-2 관련 질병의 발병과 잠재적으로 겹칩니다Article Published on 2021-01-012022-09-11 Journal: Gastroenterology [Category] Fulltext, SARS, 비임상, 임상, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition biologic bowel breath brush border confluence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection defined drug enterocytes expression Gastrointestinal symptom gastrointestinal symptoms generate GI Tract IBD IBD Medications Inflammation Inflammatory bowel disease Intersection intestinal intestinal inflammation intestines large cohort medications molecular network molecular response molecular responses network Network Analyses. Patient receptor Replication respiratory SARS-CoV-2 significantly Stool Support These data TMPRSS2 Treatment treatment of COVID-19 Viral Viral RNA [DOI] 10.1053/j.gastro.2020.09.029 PMC 바로가기 [Article Type] Article
How to boost the immune defence prior to respiratory virus infections with the special focus on coronavirus infectionsReview Published on 2020-10-122022-11-01 Journal: Gut Pathogens [Category] COVID-19, [키워드] “cytokine storm” Abnormalities activation of platelets addition administration anorexia Anxiety boost can be used cause Coagulation Coronavirus infection COVID-19 COVID-19 pandemic Critically ill patient cytokine expression defend diarrhea diarrhoea digestive Factors feature fraction gut microbiota Health healthy helping Human immune immune system immunomodulatory in healthy individual individual intestinal inflammation microbial infection microbial infections modulated novel coronavirus SARS-CoV-2 plasma previous study reduce reduced respiratory tract infection Respiratory virus infection Respiratory virus infections respond risk Saccharomyces cerevisiae shown Stress Support Symptoms synergistic Vaccine viral infections vitamins C vomiting weakened with COVID-19 yeast [DOI] 10.1186/s13099-020-00385-2 PMC 바로가기 [Article Type] Review
Probiotics, Prebiotics, Synbiotics, and Paraprobiotics as a Therapeutic Alternative for Intestinal MucositisReview Published on 2020-09-172023-08-30 Journal: Frontiers in Microbiology [Category] E형 간염, [키워드] Chemotherapy intestinal inflammation Lactic acid bacteria mucosite Treatment [DOI] 10.3389/fmicb.2020.544490 PMC 바로가기 [Article Type] Review
The Contribution of Eimeria Coinfection and Intestinal Inflammation to Cecal Colonization and Systemic Spread of Salmonella Typhimurium Deficient in Tetrathionate Reductase or Type III Secretion Systems Salmonella Pathogenicity Island 1 or 2article Published on 2019-12-312024-09-01 Journal: Avian Dis [Category] 살모넬라증, [키워드] Eimeria intestinal inflammation Salmonella Pathogenicity Island 1 (SPI-1) Salmonella Pathogenicity Island 2 (SPI-2) Salmonella Typhimurium tetrathionate reductase [Article Type] article
Astragalus polysaccharides attenuated inflammation and balanced the gut microflora in mice challenged with Salmonella typhimuriumarticle Published on 2019-09-302024-09-01 Journal: International Immunopharmacology [Category] 살모넬라증, [키워드] Astragalus polysaccharides Gut microflora intestinal inflammation Salmonella Typhimurium TLR4/MyD88/NF-κB [Article Type] article
Porcine transmissible gastroenteritis virus nonstructural protein 2 contributes to inflammation via NF-κB activationResearch Paper Published on 2018-10-292022-10-28 Journal: Virulence [Category] Coronavirus, [키워드] activated activating acute enteritis Affect Amino acid amino acid residue bovine cause caused Cell contribute Critical Culture demonstrated domain down-regulation Eagle epithelial cell line exhibited expression fetal gastroenteritis indicated individual Infection infections Inflammation Inflammatory response inhibitor intestinal intestinal inflammation involved IκB monoclonal Necrosis NF-κB NF-κB NF-κB activation nitric oxide NSP2 nuclear p65 Pathogenesis pro-inflammatory cytokine pro-inflammatory cytokines Protein Regulation Replication reporter reverse transcription significantly suggested TGEV These data tissue transcription factor transmissible gastroenteritis virus Viral protein virus [DOI] 10.1080/21505594.2018.1536632 PMC 바로가기 [Article Type] Research Paper