Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease만성 신장 질환 마우스 모델에서 SARS-CoV-2 수용체, 안지오텐신 전환 효소 2의 조직 특이적 발현Article Published on 2021-08-192022-09-12 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenine albumin Alter angiotensin angiotensin-converting enzyme 2 blocker blood pressure can be used changes in Chronic kidney disease CKD controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient Diseases elevated examined expression functional groups hypertension Infection investigated kidney Kidney disease Kidney diseases mice mouse model not affect not differ olmesartan organ organs pathological conditions Patient RAS receptor reduced renal renin–angiotensin system risk risk of COVID-19 severe acute respiratory syndrome Coronavirus significantly target the SARS-CoV-2 tissue-specific expression Treatment urinary albumin excretion [DOI] 10.1038/s41598-021-96294-8 PMC 바로가기 [Article Type] Article
Coronavirus Disease (COVID)-19 and Diabetic Kidney DiseaseReview Published on 2021-07-302022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] accelerate ACE2 Activation acute respiratory syndrome addition Altered AMP-activated protein kinase (AMPK) AMPK angiotensin-converting enzyme (ACE) angiotensin-converting enzyme 2 Cell cell type cell types cells cellular homeostasis circular RNAs coronavirus Coronavirus Disease (COVID)-19 COVID-19 associated nephropathy COVID-19 patients COVID-19 severity Cytokine storm diabete diabetes Diabetic diabetic kidney disease dipeptidyl peptidase (DPP)-4 disrupt endothelial cells endothelial-to-mesenchymal transition endotheliopathy epithelial cells epithelial-to-mesenchymal transition expression facilitate fibrosis homeostasis Infection Injury interact kidney Kidney disease Kidney diseases lncRNAs Macrophage macrophages MAS1 mechanism microRNA MicroRNAs Neutrophils organ Organ failure pathogenic Platelets protective role Protein Proteins provided reaction receptor Replication resulting SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Signaling stability standard care Support target therapy thrombus formation viral entry [DOI] 10.3390/ph14080751 PMC 바로가기 [Article Type] Review
Impact of the COVID-19 Pandemic on Kidney Diseases Requiring Renal Biopsy: A Single Center Observational StudyPhysiology Published on 2021-07-082022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] addition affected biopsy center coronavirus COVID-19 COVID-19 lockdown COVID-19 pandemic Diagnosis diagnostic disease Germany healthcare service hemoglobinuria hospital hypertensive hypertensive nephropathy Impact impacted Kidney disease Kidney diseases knowledge lockdown medical service medical services nephropathy pandemic Patient patients Proteinuria renal renal biopsy Result resulting retrospective risk factor social distancing subpopulation susceptible [DOI] 10.3389/fphys.2021.649336 PMC 바로가기 [Article Type] Physiology
Factors Behind the Higher COVID-19 Risk in Diabetes: A Critical ReviewPublic Health Published on 2021-07-072022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition Adults Aerosols affected angiotensin blocker Comorbidities Comorbidity complications confirmed cases coronavirus coronavirus disease COVID-19 COVID-19 severity death diabetes droplets enzyme Factor Glucose glycemia higher risk hyperglycemia hypertension immune response Immunological disorders Inflammatory response Injury insulin resistance Kidney diseases life-threatening management mandatory Mortality neuroendocrine Numerous pancreatic pandemic Patient patients patients with COVID-19 Predictive Prevent public health receptor review SARS-CoV-2 severe disease severity Spread susceptibility virus WHO World Health Organization [DOI] 10.3389/fpubh.2021.591982 PMC 바로가기 [Article Type] Public Health
Increased risk of acute kidney injury in coronavirus disease patients with renin–angiotensin–aldosterone-system blockade use: a systematic review and meta-analysisArticle Published on 2021-06-302022-10-04 Journal: Scientific Reports [Category] MERS, 임상, [키워드] 95% confidence interval Acute kidney injury Affect AKI Analysis association blockade Complication concern coronavirus disease COVID-19 COVID-19 patient COVID-19 patients database estimate hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient Increased increased risk investigated Kidney diseases Kidney injury Meta-analysis Odds ratio outcome Patient patients potential risk RAAS raised random-effects model renal risk searched severity significantly Stratification systematic review viral infection [DOI] 10.1038/s41598-021-92323-8 PMC 바로가기 [Article Type] Article
Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection인간의 신장은 신종 중증급성호흡기증후군 코로나바이러스 2 감염의 표적이 된다Article Published on 2021-05-042022-09-10 Journal: Nature Communications [Category] SARS, 임상, 진단, 치료법, [키워드] accumulate Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AKI angiotensin angiotensin converting enzyme Antigen antigens Autopsy C5b-9 CD68 CD68+ macrophage clinical parameter Clinical parameters Comorbidities Comorbidity complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient damage-associated molecules develop double staining Elderly patient elderly patients ENhance eosin exhibited expression Haematoxylin heart failure Histopathology Human human kidney hypertension hypoxic hypoxic damage immunofluorescence immunohistochemistry In situ hybridization infect Infection infiltration kidney Kidney diseases kidneys laboratory-confirmed lead macrophages moderate moderate to severe nucleocapsid Pathogenesis Patient Post-mortem prostaglandin respiratory Retrospective analysis SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein staining Trigger triggers Viral Viral RNA was performed [DOI] 10.1038/s41467-021-22781-1 PMC 바로가기 [Article Type] Article
Recovery of new-onset kidney disease in COVID-19 patients discharged from hospital퇴원한 COVID-19 환자의 새로운 발병 신장 질환의 회복Research Published on 2021-04-292022-09-10 Journal: BMC Infectious Diseases [Category] MERS, 치료제, [키워드] age coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 hospitalization COVID-19 patient COVID-19 patients creatinine death Descriptive statistics discharge discharged discharged patient Elderly patient Follow-up Health hospital Hospitalization information IQR kidney Kidney disease Kidney diseases median median age men MOST number of deaths Patient prospective cohort study Renal recovery Result serum creatinine significantly higher supplementary material the median were used [DOI] 10.1186/s12879-021-06105-8 PMC 바로가기 [Article Type] Research
Kidney injury molecule-1 is a potential receptor for SARS-CoV-2Articles Published on 2021-03-252022-10-30 Journal: Journal of Molecular Cell Biology [Category] COVID-19, SARS, [키워드] Abnormalities addition bind cell membrane coronavirus COVID-19 COVID-19 patient domain energy transfer exacerbate facilitate fluorescein isothiocyanate Immunoglobulin in silico incidence Infection Injury Interaction kidney Kidney diseases Kidney injury kidney injury molecule-1 labeling MERS-CoV Mortality other coronaviruses pathogen peptides poor prognosis RBD receptor renal respiratory diseases SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD the RBD the receptor-binding domain therapeutic target tropism of SARS-CoV-2 upregulated [DOI] 10.1093/jmcb/mjab003 PMC 바로가기 [Article Type] Articles
Fear of COVID-19 for Individuals and Family Members: Indications from the National Cross-Sectional Study of the EPICOVID19 Web-Based SurveyArticle Published on 2021-03-212022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] adjusted age analyzed Anxiety association average calculated Characteristics chest pain chronic disease Contact Contagion coronavirus disease (COVID-19) COVID-19 COVID-19 pandemic Depression disease disorders Factors family fear First wave flu flu vaccination Health Health status highest hypertension indication individual Italian Kidney diseases knowledge Logistic regression lung men Nasopharyngeal swab Odds ratio palpitation positive response public health questionnaire regions Risk perception Self-reported symptoms Sex specific symptom survey Symptom trend voluntary respondents was performed web-based survey with COVID-19 women [DOI] 10.3390/ijerph18063248 PMC 바로가기 [Article Type] Article
Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019Review Published on 2021-03-012023-07-06 Journal: The Korean journal of internal medicine [Category] SARS, [키워드] angiotensin converting enzyme 2 cardiovascular diseases COVID-19 Kidney diseases severe acute respiratory syndrome coronavirus 2 [DOI] 10.3904/kjim.2020.355 PMC 바로가기 [Article Type] Review