Multicenter point prevalence evaluation of the utilization and safety of drug therapies for COVID-19 at the onset of the pandemic timeline in the United States미국에서 유행성 타임라인이 시작될 때 COVID-19에 대한 약물 요법의 사용 및 안전성에 대한 다기관 점 유병률 평가Multicenter Study Published on 2021-03-182022-09-11 Journal: American journal of health-system pharmacy : AJHP [Category] SARS, 치료제, [키워드] addition ADR ADRS Adverse drug reaction Adverse drug reactions Adverse reaction Adverse reactions antagonist Asthma Characteristics clinical Clinical data clinical trial clinical trials combination therapy Community Comprehensive conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatments drug reaction drug therapy enrolled evaluated hospital Hydroxychloroquine identify interleukin interleukin-6 lAbel medication medication safety medications mitigate Most patient Most patients multicenter observational study occurred Odds ratio off-label pandemic Patient patients patients hospitalized patients treated patients with COVID-19 point prevalence Prevalence prevalence study random Random sample receiving Remdesivir SARS-CoV-2 supported supportive care the United State Therapies therapy treated Treatment while [DOI] 10.1093/ajhp/zxaa426 PMC 바로가기 [Article Type] Multicenter Study
The Impact of the Covid-19 Pandemic on Consumers’ Intention to Use Shared-Mobility Services in German CitiesPsychology Published on 2021-03-012022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] Affect Analysis analyzed Bill Gate Carsharing city Climate change conditions conducted consequence consumer contribute coronavirus COVID-19 decrease ecological Emissions environmental claim experiment explain FIVE highlighting Impact implication information Intention lAbel measure mechanism Mediation analysis Mental negative influence offer outbreak pandemic participant perceived ecological benefits perceived physical risk physical platform reduce Research Result risk risk perceptions safety claim service Signaling stimulate turn [DOI] 10.3389/fpsyg.2021.646593 PMC 바로가기 [Article Type] Psychology
Hydroxychloroquine for the treatment of COVID-19 and its potential cardiovascular toxicity: Hero or villain?COVID-19 및 잠재적인 심혈관 독성 치료를 위한 하이드록시클로로퀸: 영웅 또는 악당?Review Published on 2021-03-012022-09-11 Journal: Best practice & research. Clinical rheumatology [Category] SARS, 치료법, 치료제, [키워드] antimalarial Antimalarials cardiovascular risk Chloroquine controlled trials coronavirus coronavirus disease COVID-19 COVID-19 treatment crisis Evidence Hero Hydroxychloroquine investigated lAbel medication observational studies observational study off-label off-label use outcome pandemic Randomized controlled trials Rheumatic diseases Treatment variety widespread [DOI] 10.1016/j.berh.2020.101658 PMC 바로가기 [Article Type] Review
An Open Label Trial to Assess Safety of Losartan for Treating Worsening Respiratory Illness in COVID-19Medicine Published on 2021-02-172022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 1:1 Administered adverse event adverse events age angiotensin receptor blocker angiotensin receptor inhibitors ARBs average Bayesian capillary leakage Comorbidities contributing to control group controls Coronavirus disease 2019 COVID-19 COVID−19 cumulative disease severity Efficacy Endpoint enrolled Enrollment hospital discharge Hospitalized illness IMPROVE incidence incidence rate inclusion criteria Inflammation lAbel losartan Lungs male measure open label oral outcome participant Patient Poisson regression post-hoc randomized trial renin-angiotensin system respiratory respiratory compromise Respiratory failure Safe Safety secondary Sex treating treatment group Trial vital status [DOI] 10.3389/fmed.2021.630209 PMC 바로가기 [Article Type] Medicine
SAveRUNNER: A network-based algorithm for drug repurposing and its application to COVID-19SAveRUNNER: 약물 용도 변경을 위한 네트워크 기반 알고리즘 및 COVID-19에 적용Research Article Published on 2021-02-052022-09-02 Journal: PLoS Computational Biology [Category] MERS, 신약개발, 임상, 치료제, [키워드] (hydroxychloroquine Algorithm anti-IL6 anti-TNF applied Arthritis association cardiovascular diseases Chloroquine Clinical practice combination therapy Comorbidity coronavirus Coronavirus infections COVID-19 COVID-19 treatment COVID-19 treatments de novo disease disease-causing downstream drug Drug discovery drug target drugs effective drug effective drugs Efficiency enrichment analysis experiments Focusing gene set enrichment analysis Genetic heparin HIV human coronavirus Hydroxychloroquine in-silico include inhibitors knowledge lAbel lack Lopinavir malaria monoclonal antibodies monoclonal antibody network off-label Potential treatment predict Protein reduce Remdesivir remdesivir) repositioning rheumatoid arthritis rheumatoid arthritis) Ritonavir selected similarity thrombin Tocilizumab treat Vaccine variety worldwide pandemic PMC 바로가기 [Article Type] Research Article
Clinical guidance for navigating the QTc-prolonging and arrhythmogenic potential of pharmacotherapy during the COVID-19 pandemicCOVID-19 전염병 동안 약물 요법의 QTc 연장 및 부정맥 발생 가능성을 탐색하기 위한 임상 지침Review Published on 2021-02-012022-09-11 Journal: Irish Journal of Medical Science [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Azithromycin cardiac death clinical clinical evidence contagious coronavirus coronavirus disease COVID-19 COVID-19 pandemic death deleterious effect disease drug drug-induced Drug-induced QTc prolongation focus Guidance guidelines Healthcare provider healthcare providers Healthcare system Healthcare systems help Hydroxychloroquine Kaletra lAbel Lopinavir Lopinavir/ritonavir medication medications mitigate Mortality Prevent public health QT interval QTc QTC prolongation respiratory responsible Ritonavir robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread sudden cardiac death torsades de pointes treat Treatment [DOI] 10.1007/s11845-020-02291-7 PMC 바로가기 [Article Type] Review
[Fatal course of COVID-19 despite IL-6 receptor blockade in cytokine storm : Perimyocarditis and coagulopathy after administration of tocilizumab][사이토카인 폭풍에서 IL-6 수용체 차단에도 불구하고 코로나19의 치명적인 경과 : 토실리주맙 투여 후 심근주위염 및 응고병증]Case Reports Published on 2021-02-012022-09-11 Journal: Anaesthesist [Category] 진단, 치료제, [키워드] Administered administration Admission ARDS Azithromycin blockade can not Cardiac arrhythmia circulatory shock Clinical deterioration Coagulopathy Course COVID-19 criteria cytokine Cytokine storm diagnosed died ECMO Efficacy English Exacerbation hemodynamic instability hospital Hydroxychloroquin Hydroxychloroquine IL-6 receptor inflammation marker initiated lAbel male moderate multiorgan failure occurred off-label Patient patient selection Perimyocarditis Pneumonia Randomized controlled studies receptor receptor antagonist respiratory insufficiency second dose Shock Tage the patient Tocilizumab Treatment treatment with tocilizumab with COVID-19 worsened [DOI] 10.1007/s00101-020-00871-x PMC 바로가기 [Article Type] Case Reports
Plasma Concentrations and Safety of Lopinavir/Ritonavir in COVID-19 PatientsCOVID-19 환자에서 로피나비르/리토나비르의 혈장 농도 및 안전성Article Published on 2021-02-012022-09-11 Journal: Therapeutic drug monitoring [Category] 치료제, [키워드] absence Adverse drug reaction Adverse drug reactions antiviral activity average caution Concentration COVID-19 COVID-19 patient disorders dosage drug reaction Efficacy expected HIV HIV treatment in vivo increase in Inflammation Inflammatory interquartile lAbel limit Lopinavir Lopinavir/ritonavir moderate-to-severe COVID-19 Occurrence off-label off-label use one patient Patient plasma concentration plasma concentrations Previous studies reduced reported required Retrospective study Ritonavir Safety safety profile SARS-CoV-2 significantly suggested treated Treatment treatment for COVID-19 [DOI] 10.1097/FTD.0000000000000838 PMC 바로가기 [Article Type] Article
Global Safety Database Summary of COVID-19-Related Drug Utilization-Safety Surveillance: A Sponsor’s PerspectiveCOVID-19 관련 약물 사용-안전 감시의 글로벌 안전 데이터베이스 요약: 후원자의 관점Observational Study Published on 2021-01-012022-09-11 Journal: Drug safety [Category] 임상, 치료제, [키워드] activity adverse event Antibiotics Anticoagulant Anticoagulants antimalarial association Azithromycin ceftriaxone characterized Chloroquine chloroquine/hydroxychloroquine Clinical data collected conditions coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 COVID-19 case COVID-19 cases COVID-19 treatment database diarrhea Dictionary drug drug interaction electrocardiogram event events followed by Hepatitis Hydroxychloroquine Immunoglobulin immunomodulating agents Immunosuppressant immunosuppressive effect immunosuppressive effects include individual Infection interferons lAbel Lopinavir Lopinavir-ritonavir MedDRA off-label over Pfizer provide QT prolongation receiving reported retrospective Ritonavir Safety Seven subsequent Surveillance term therapeutic therapy Tofacitinib Torsade de Pointes treated treated patients Treatment unique were used [DOI] 10.1007/s40264-020-01035-x PMC 바로가기 [Article Type] Observational Study
Drugs supply and pharmaceutical care management practices at a designated hospital during the COVID-19 epidemicCOVID-19 전염병 동안 지정된 병원의 약물 공급 및 의약품 관리 관행Review Published on 2021-01-012022-08-31 Journal: Research in social & administrative pharmacy : RSA [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjusted Adverse reaction Adverse reactions affected assigned Care caused characterized China conducted coronavirus coronavirus disease Coronavirus disease-19 Coronavirus disease-19 (COVID-19) COVID-19 COVID-19 diagnosis COVID-19 epidemic COVID-19 patient COVID-19 patients cured Diagnosis drug Drug supply Epidemic Health Organization hospital lAbel management medication medication errors mood Northeast China Nosocomial infection Nosocomial infections occurred off-label offer outbreak pandemic participated pharmaceutical Pharmaceutical service Practice Prevention and control Region respiratory serious adverse reaction service offers shown the epidemic Treatment World Health Organization [DOI] 10.1016/j.sapharm.2020.04.001 PMC 바로가기 [Article Type] Review