Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination예방 접종 없이 SARS-CoV-2 Omicron에 대한 제한된 교차 변이 면역Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] Activation arise Brain brains Breakthrough infection cause Cytokines Delta disease elicited ENhance expression human ACE2 receptor humans humoral immune response Immunity individual individuals induce Infection infections lead Limited lung Lung disease Lungs mice Mild Mild disease neutralization neutralize omicron other variant overexpressing pandemic pre-existing immunity pro-inflammatory cytokine pro-inflammatory cytokines question reduced replicate risk SARS-CoV-2 SARS-CoV-2 delta sera Symptoms T cells titre vaccinated individual vaccinated individuals vaccination Vaccine variant variants of concern WA1 widespread [DOI] 10.1038/s41586-022-04865-0 PMC 바로가기 [Article Type] Article
Replacement of the Alpha variant of SARS-CoV-2 by the Delta variant in Lebanon between April and June 2021Article Published on 2022-07-012022-11-16 Journal: Microbial Genomics [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] age Alpha variant ARTIC protocol bioinformatics changed circulating circulation community transmission country COVID-19 COVID-19 infection COVID-19 pandemic delta variant Eastern Mediterranean Region expand Genome Genome sequencing genomic Genomic epidemiology increase in introduced Limited Lineage nine peaked Prospective remains uncertain replaced replacement rising SARS-CoV-2 SARS-CoV-2 genome selected sequenced Sequencing Sex Surveillance surveillance network Travel variant [DOI] 10.1099/mgen.0.000838 PMC 바로가기
Incidence and effects of deep vein thrombosis on the outcome of patients with coronavirus disease 2019 infectionObservational Study Published on 2022-07-012022-10-05 Journal: Journal of vascular surgery. Venous and lymphatic [Category] 임상, [키워드] 95% CI 95% confidence interval adjusted age Analysis anticoagulation ARDS Characteristics comparison contributing to coronavirus disease COVID-19 COVID-19 group COVID-19 patient COVID-19 patients Deep vein Deep vein thrombosis determine distress DVT Effect Factor ICU ICU Patients incidence increased mortality Infection intensive care Limited male Mortality multiple organ failure non-COVID-19 patient Observational cohort study occur outcome outcomes Patient patients with COVID-19 patients without COVID-19 performed Primary outcome Prophylactic receiving reported retrospective risk factor Standard Standard-dose surgical syndrome therapy Thromboprophylaxis thrombosis trauma trauma patient treated ventilatory support [DOI] 10.1016/j.jvsv.2021.10.013 PMC 바로가기 [Article Type] Observational Study
Heart-lung interactions in COVID-19: prognostic impact and usefulness of bedside echocardiography for monitoring of the right ventricle involvementCOVID-19의 심장-폐 상호작용: 우심실 침범 모니터링을 위한 병상 심장 초음파의 예후 영향 및 유용성Review Published on 2022-07-012022-09-11 Journal: Heart failure reviews [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition adverse effect Afterload appear avoidance circulation Clinical deterioration contribute COVID-19 Critically ill critically ill patients dysfunction echocardiography extracorporeal membrane oxygenation facilitate heart heart failure Heart–lung interaction hemodynamic instability high mortality high risk hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients Hypoxemia IMPROVE increase in Interaction involved limit Limited management mechanical ventilation medication optimization outcome pathophysiologic Patient patient survival patients with COVID-19 pressure overload prognostic progression pulmonary pulmonary circulation pulmonary vascular resistance Pulmonary vessel thrombosis reducing Respiratory failure right heart failure right ventricle RV dysfunction SARS-COV-2 infection severe COVID-19 small vessel the SARS-CoV-2 thrombosis thrombotic thrombotic microangiopathy tissue damage transthoracic echocardiography Treatment TTE Vascular Vascular resistance ventricular vessel widespread [DOI] 10.1007/s10741-021-10108-7 PMC 바로가기 [Article Type] Review
Diagnostic Accuracy of SARS-CoV-2 Nucleocapsid Antigen Self-Test in Comparison to Reverse Transcriptase-Polymerase Chain ReactionArticle Published on 2022-06-302022-11-15 Journal: The journal of applied laboratory medicine [Category] COVID19(2023년), SARS, 진단, [키워드] Accuracy Antigen approved chain colloidal gold conducted conserved Council COVID-19 COVID-19 diagnosis diagnostic Effects evaluated false-negative ICMR Limited Mutation N-antigen nucleocapsid antigen offered ORF1ab gene positive result rapid test kit reaction RT-PCR RT-PCR assay RT-PCR Ct RT-PCR kit RT–PCR S-gene SARS-CoV-2 self-test. sensitivity stability the disease the patient Thermo Fisher Scientific threshold validation study was performed [DOI] 10.1093/jalm/jfac023 PMC 바로가기
Convalescent plasma with a high level of virus-specific antibody effectively neutralizes SARS-CoV-2 variants of concern높은 수준의 바이러스 특이적 항체가 있는 회복기 혈장은 우려되는 SARS-CoV-2 변이체를 효과적으로 중화합니다Article Published on 2022-06-282022-09-11 Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody CCP convalescent plasma coronavirus correlated COVID-19 COVID-19 convalescent plasma Donor donors drug Drug administration effective effective drugs Efficacy Euroimmun Evolution examined exposure to food Food and Drug Administration high-titer CCP Hospitalization Immunoglobulin Immunoglobulin G Immunosuppressed limit Limited monoclonal antibody monoclonal antibody therapies neutralization neutralize neutralized plasma polyclonal reduce respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Therapies variant variants virus Virus neutralization [DOI] 10.1182/bloodadvances.2022007410 PMC 바로가기 [Article Type] Article
Glucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2글루코코르티코이드는 여러 부위에서 SARS-CoV-2 S1에 결합하여 ACE2와 SARS-CoV-2 S1 상호작용을 협력적으로 억제합니다Article Published on 2022-06-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 (angiotensin converting enzyme 2) Affect Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-SARS-CoV-2 Asymptomatic Beta bind binding binding energy binding pocket binding pockets biochemical biochemically catalytic activity causing cellular receptor chimeric conformational state contributed Cooperative coronavirus cortisol COVID COVID-19 patients Delta Dexamethasone disrupt E484K enzyme Glucocorticoids indicated inhibition Innate immunity Interaction K417N Limited mass spectrometry mechanism Mild molecular molecular dynamics monoclonal antibody Multiple mutant mutated N501Y omicron Omicron variants Protein Receptor binding domain reduce mortality SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 spike Site variant without affecting [DOI] 10.3389/fimmu.2022.906687 PMC 바로가기 [Article Type] Article
Structural Plasticity and Immune Evasion of SARS-CoV-2 Spike VariantsSARS-CoV-2 스파이크 변이체의 구조적 가소성 및 면역 회피Review Published on 2022-06-092022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] accumulated mutation accumulated mutations acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected affecting antibody antibody escape approach atomic binding Care caused cells conformations coronavirus COVID-19 COVID-19 pandemic functions global pandemic Health Health care Health care system Host immune immune evasion Infection Interpretation Limited molecular molecular mechanism mutations parental profiles protective vaccines Protein recent finding recent findings resolved S protein S variant SARS-CoV-2 SARS-CoV-2 variants scientist severe acute respiratory syndrome Coronavirus shifting significantly spike Spike proteins Structure structures therapeutic option Transmissibility Vaccines variants variants of concern virus entry virus transmissibility Virus-host interaction Virus-host interactions VoC VOCs Wuhan-Hu-1 [DOI] 10.3390/v14061255 PMC 바로가기 [Article Type] Review
Characterization and determinant factors of critical illness and in-hospital mortality of COVID-19 patients: A retrospective cohort of 1,792 patients in KenyaResearch article Published on 2022-06-012022-10-05 Journal: Biosafety and Health [Category] 바이오마커, 유전자 메커니즘, [키워드] 95% confidence interval addition Admission admitted to ICU African Asymptomatic cardiovascular disease characteristic characterization CLD clinical feature Comorbidities Comorbidity conducted coronavirus disease COVID-19 COVID-19 patient Critical Critical illness determinant determinant factor determine diabetes died dry cough Factor Fever headache Health status hospital ICU ICU admission in-hospital mortality indicated intensive care Kaplan-Meier Kenya Limited Logistic regression Lung disease majority male Mortality multivariate obesity Older age oxygen oxygen saturation Patient patients died predictor prevalent retrospective cohort retrospective cohort study risk risk factor SARS-CoV-2 Shortness of breath smoking survival survival analysis was used [DOI] 10.1016/j.bsheal.2022.06.002 [Article Type] Research article
Receptor binding domain-IgG levels correlate with protection in residents facing SARS-CoV-2 B.1.1.7 outbreaks수용체 결합 도메인-IgG 수준은 SARS-CoV-2 B.1.1.7 발병에 직면한 거주자의 보호와 상관관계가 있습니다.Article Published on 2022-06-012022-09-11 Journal: Allergy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] antibody Antibody Response antigenemia association B.1.1.7 binding BNT162b2 BNT162b2 vaccine Chain Reaction COVID-19 death domain dose Efficacy humoral IgG levels in vitro incidence information Limited Nasopharyngeal swab nasopharyngeal swab test Neutralizing Neutralizing antibodies nucleocapsid nucleocapsid antigenemia nursing home nursing homes outbreak polymerase chain polymerase chain reaction positive Post-vaccine qPCR RBD reduction residents reverse-transcriptase polymerase chain reaction risk risk factor RT-qPCR S1 subunit SARS-CoV-2 SARS-CoV-2 B.1.1.7 Serum Neutralization Serum neutralizing antibody Seven severe COVID-19 severe symptoms Symptom Symptoms tested the S1 subunit Vaccine was measured [DOI] 10.1111/all.15142 PMC 바로가기 [Article Type] Article