Enhanced mucosal immune responses and reduced viral load in the respiratory tract of ferrets to intranasal lipid nanoparticle-based SARS-CoV-2 proteins and mRNA vaccinesarticle Published on 2023-02-222024-09-05 Journal: Journal of Nanobiotechnology [Category] update2024, [키워드] ferrets intranasal vaccination Lipid nanoparticles mRNA Subunit antigens [DOI] 10.1186/s12951-023-01816-3 PMC 바로가기 [Article Type] article
Split-Dose Administration Enhances Immune Responses Elicited by a mRNA/Lipid Nanoparticle Vaccine Expressing Respiratory Syncytial Virus F ProteinArticle Published on 2023-01-022023-07-10 Journal: Molecular Pharmaceutics [Category] COVID19(2023년), [키워드] Lipid nanoparticles mRNA vaccines split-dose administration sustained delivery. [DOI] 10.1021/acs.molpharmaceut.2c00635
Exploring in vitro expression and immune potency in mice using mRNA encoding the Plasmodium falciparum malaria antigen, CelTOSarticle Published on 2022-12-312024-09-01 Journal: Frontiers in immunology [Category] 말라리아, [키워드] CelTOS Lipid nanoparticles malaria Malaria vaccine mRNA N-glycosylation nucleoside modifications Plasmodium falciparum [Article Type] article
Rapid Generation of Circulating and Mucosal Decoy Human ACE2 using mRNA Nanotherapeutics for the Potential Treatment of SARS-CoV-2Article Published on 2022-12-012023-07-10 Journal: Advanced Science [Category] COVID19(2023년), [키워드] COVID-19 Gene therapy human soluble ACE2 Lipid nanoparticles messenger RNA. [DOI] 10.1002/advs.202202556 PMC 바로가기
A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugsResearch article Published on 2022-10-012022-10-05 Journal: Journal of controlled release : official journal o [Category] 신약개발, [키워드] addition approach approval bovine CAD cancer cell cationic Cationic amphiphilic drugs Cationic lipid Cell Cellular delivery component Corneal COVID-19 mRNA vaccines drug drug combination Drug repurposing Efficiency encapsulation epithelial cell epithelial cells eyes functional healthcare HeLa cell in vitro in vivo Lipid lipid component Lipid nanoparticles Liposome LNP maintain Messenger RNA mRNA nanomedicine Patient pharmacological platform primary cell RNA RNA therapeutics selected small molecule drug subsequent Therapies Vesicle was obtained [DOI] 10.1016/j.jconrel.2022.08.009 [Article Type] Research article
Lipid nanoparticle formulations for optimal RNA-based topical delivery to murine airwaysArticle Published on 2022-09-012023-07-09 Journal: European journal of pharmaceutical sciences : offi [Category] COVID19(2023년), [키워드] airway epithelial cells Lipid nanoparticles mRNA Nasal cavity siRNA [DOI] 10.1016/j.ejps.2022.106234
mRNA vaccines: Past, present, futureReview article Published on 2022-07-012022-10-05 Journal: Asian Journal of Pharmaceutical Sciences [Category] 비임상, [키워드] addition adjuvant Cancer candidate carrier Clinical use conventional vaccines COVID-19 Diseases ENhance in vitro Lipid nanoparticles mRNA mRNA stability mRNA vaccine Nanoparticles outcomes Pandemics platform provide provided RNA safety profile shown tissue transcribed Treatment vaccine platform viral disease virus widespread [DOI] 10.1016/j.ajps.2022.05.003 [Article Type] Review article
Lung targeted liposomes for treating ARDSARDS 치료를 위한 폐 표적 리포솜Article Published on 2022-06-012022-09-11 Journal: Journal of controlled release : official journal o [Category] 치료제, [키워드] accumulate accumulation acute respiratory distress acute respiratory distress syndrome Administered administration alveolar approach ARDS BAL Bronchoalveolar lavage C57BL/6 characterized combined treatment COPD COVID-19 COVID-19 infections cysteine cytokine secretion distal DPPC drug Efficiency encapsulation endotracheal exhibited Gas exchange Hypoxemia IL-1β IL-6 impair infections Inflammation Inflammatory marker inflammatory markers intravenous intravenously lipid composition Lipid nanoparticles lipopolysaccharide Liposome lung lung damage Lung diseases lung disorders lung endothelial lung epithelial Lung inflammation Lungs Macrophage macrophages marker medication Methylprednisolone mice mortality rate mortality rates MPS mucolytic agent Mucus N-acetyl cysteine NAC nanoparticle Nanotechnology nitric oxide outcome Patient penetration provided pulmonary reached reduce reducing Region respiratory respiratory distress Respiratory distress syndrome secretion steroid syndrome therapeutic therapeutic effect therapeutic efficacy TNFα Treatment Treatment outcome were assessed [DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article
A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models자가 증폭 mRNA SARS-CoV-2 백신 후보는 전임상 모델에서 안전하고 강력한 보호 면역을 유도합니다Clinical Trial Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 임상, 진단, [키워드] (Alpha) (Beta Alpha animals Antigen B.1.1.7 B.1.351 B.1.617.2 Beta biodistribution breath CD4 CD8 T cell CD8 T cell responses characterized clinical evaluation Delta demonstrated disease dose-dependent manner Efficacy elicit elicited emergency response Evidence evidence of Frequency Germinal center hamsters humans immune responses immunization immunogenicity induce Lipid nanoparticle Lipid nanoparticles LNP lower airways Messenger RNA mice mRNA neutralized no evidence of Phase 1 Protective protective immune response protective immunity RATs reduced response RNA RNA vaccines robust Safe safety profile SAM SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variants SARS-CoV-2 Wuhan strain self-amplifying mRNA Spike antigen spike-specific antibody response T cell the SARS-CoV-2 the vaccine Tolerance Toxicity upper and lower airways Vaccine vaccine candidate variants Viral Viral load Wuhan-Hu-1 [DOI] 10.1016/j.ymthe.2022.01.001 PMC 바로가기 [Article Type] Clinical Trial
Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acidsReview Published on 2022-05-012023-07-08 Journal: Advanced drug delivery reviews [Category] COVID19(2023년), [키워드] CRISPR-delivery gene delivery Lipid nanoparticles Microfluidics Non-viral vectors. [DOI] 10.1016/j.addr.2022.114197 PMC 바로가기 [Article Type] Review