Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single-cell analysis긴 비 코딩 RNA (LNCRNA) NEAT1 및 MALAT1은 심각한 COVID-19 환자에서 차등 적으로 발현됩니다. 통합 된 단일 세포 분석Research Article Published on 2022-01-102022-09-10 Journal: PLoS ONE [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] Analysis analyzed Apoptosis applied BAL Bronchoalveolar lavage Cell cell population cell stress cell types cellular stress response component coronavirus disease Coronavirus disease 2019 COVID-19 damage diagnostic differentially expressed differentiator disease severity dysregulation focus foster hallmark immune dysregulation immunomodulatory Inflammation Inflammatory involved lncRNA Long long non-coding RNA MALAT1 measure Mild mononuclear cell mononuclear cells NEAT1 non-coding RNA Patient PBMCs Peripheral blood Peripheral blood mononuclear cells pro-inflammatory function pro-inflammatory functions Regulation sequenced severe COVID-19 Severe patient severity single-cell single-cell RNA-seq dataset single-cell transcriptomic analysis stress response target targets therapy with COVID-19 [DOI] 10.1371/journal.pone.0261242 PMC 바로가기 [Article Type] Research Article
A new insight into sex-specific non-coding RNAs and networks in response to SARS-CoV-2Article Published on 2021-12-232023-07-01 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, [키워드] ACE, angiotensin-converting enzyme COVID-19 DEGs, differentially expressed genes DEmRNAs, differentially expressed mRNAs GEO, Gene Expression Omnibus GO, Gene ontology GSEA, gene set enrichment analysis lncRNA lncRNA, long non-coding RNA microRNA miR-29 family miRNA, micro RNA SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 [DOI] 10.1016/j.meegid.2021.105195 PMC 바로가기 [Article Type] Article
Understanding Gene Expression and Transcriptome Profiling of COVID-19: An Initiative Towards the Mapping of Protective Immunity Genes Against SARS-CoV-2 InfectionCOVID-19의 유전자 발현 및 전사체 프로파일링 이해: SARS-CoV-2 감염에 대한 보호 면역 유전자 매핑을 위한 이니셔티브Immunology Published on 2021-12-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Against Agilent Analysis Arraystar CASC18 Characteristics Cluster cluster analysis co-expression COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients dataset DEGs determine differentially expressed differentially expressed gene Differentially expressed genes disease pathogenesis DLEU2 element Gene Expression Genetic genetic factor GEO dataset globe GNAS healthy control healthy controls help identify immune immune response initiative inter-individual interactome mapping involved lncRNA mapping Microarray Mild molecular mechanism Pathway enrichment analysis performed Potential biomarker potential biomarkers PPI PPI network Profiling protective immunity protein-coding gene protein-coding genes protein-protein interaction Regulatory regulatory genes response responsible SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient SNHG20 statistical TALAM1 three groups transcriptome profiling UICLM understanding Variability volunteers was used [DOI] 10.3389/fimmu.2021.724936 PMC 바로가기 [Article Type] Immunology
Co-Regulation of Protein Coding Genes by Transcription Factor and Long Non-Coding RNA in SARS-CoV-2 Infected Cells: An In Silico AnalysisArticle Published on 2021-11-292022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] Altered coded coding gene COVID-19 COVID-19 patients CRISPR deregulated deregulation expression Factor functional Gene Expression IFN treatment interferon IRFs joint lncRNA Long long non-coding RNA majority manuscript mechanism modulate modulated MYC NFκB over pathogenesis of COVID-19 pathway Pathways PCG Protein Proteins Regulation resources RNA SARS-CoV-2 SARS-CoV-2 infected cell SARS-COV-2 infection significantly STATs target TFS tissue Transcription transcription factor transcription factors transcriptional regulation [DOI] 10.3390/ncrna7040074 PMC 바로가기 [Article Type] Article
Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver CancerArticle Published on 2021-11-182023-06-03 Journal: Frontiers in Cellular and Infection Microbiology [Category] B형 간염, [키워드] HBx protein Hepatitis B virus Hepatocellular carcinoma lncRNA microRNA [DOI] 10.3389/fcimb.2021.714895 PMC 바로가기
Detection of SARS-CoV-2 genome and whole transcriptome sequencing in frontal cortex of COVID-19 patientsCOVID-19 환자의 전두엽 피질에서 SARS-CoV-2 게놈 및 전체 전사체 시퀀싱 검출Article Published on 2021-10-012022-09-11 Journal: Brain, behavior, and immunity [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] affected Analysis Brain categories category Control controls COVID-19 COVID-19 patient COVID-19 patients Defense demonstrated Deprivation detection died downregulation dysfunction examined expressed Frontal Frontal cortex Gene Expression hemoglobin hydrogen hydrogen peroxide hypoxia infect Infection inhibit investigated lncRNA Manifestations molecular mRNA mRNAs multi nervous neurological organ Patient Protein qRT-PCR quantity remains uncertain replicate RNA-seq analysis SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection Structure System tissue transcriptional Transcriptome transcriptome sequencing transcriptomic analysis transcriptomic profile Viral RNA [DOI] 10.1016/j.bbi.2021.05.012 PMC 바로가기 [Article Type] Article
SARS-CoV-2 transgressing LncRNAs uncovers the known unknownsLncRNA를 횡단하는 SARS-CoV-2는 알려진 미지의 것을 밝힙니다.Editorial Published on 2021-10-012022-09-11 Journal: Physiological Genomics [Category] SARS, 유전자 메커니즘, [키워드] asked disease pathogenesis endocytosis functional Functional genomics Host host pathogenesis hypothetical lncRNA lncRNAs long noncoding RNA mechanism molecules Open reading frame ORFs Pathogenesis Pathways Perspective Region regulate Regulatory SARS-CoV-2 SARS-CoV-2 pathogenesis the disease transgression. viral infection viral pathogenesis Viral protein Viral proteins [DOI] 10.1152/physiolgenomics.00075.2021 PMC 바로가기 [Article Type] Editorial
Muscle Regeneration and RNA: New Perspectives for Ancient MoleculesReview Published on 2021-09-232022-10-31 Journal: Cells [Category] Coronavirus, SARS, [키워드] applied approaches biochemical Biomarker cardiac regeneration coding Diseases drug Effectiveness example homeostasis Hypothesis in vitro intrinsic involved less lncRNA mechanism miRNA molecule mRNA-based vaccines muscle ncRNA ncRNAs New non-coding RNA noncoding RNAs (ncRNAs) pathology regeneration Regulation RNA RNA therapeutics SARS-CoV-2 single-stranded siRNA skeletal muscle regeneration suggested supported target therapeutic tissue Treatment unique [DOI] 10.3390/cells10102512 PMC 바로가기 [Article Type] Review
Genome interaction of the virus and the host genes and non-coding RNAs in SARS-CoV-2 infectionSARS-CoV-2 감염에서 바이러스와 숙주 유전자 및 비코딩 RNA의 게놈 상호작용Review Published on 2021-09-012022-09-11 Journal: Immunobiology [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 age candidate Candidates Comorbidities contributed COVID-19 COVID-19 pathogenesis described Factor Genes genetic polymorphisms Genetic variant Genome Genome interaction genomes groups highlight Host host gene host genome Infection Interaction involved knowledge lncRNA mechanism miRNA molecular ncRNA non-coding RNA Pathogenesis Pathways Patient populations Regulatory risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 virus Sequence analysis severity signaling pathway signaling pathways significantly SNPs SNPs, ncRNA, miRNA, lncRNA. susceptibility target gene Target genes the disease the patient TMPRSS2 Treatment strategies treatment strategy viral infectious diseases virus virus infection [DOI] 10.1016/j.imbio.2021.152130 PMC 바로가기 [Article Type] Review
Non-Coding RNAs in COVID-19: Emerging Insights and Current QuestionsReview Published on 2021-08-312022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] acute respiratory syndrome alterations characterising Clinical studies coronavirus coronavirus disease COVID-19 current Cytokine storm syndrome disease dysregulation evaluate Evidence Genome haemostasis hypothese immune cell recruitment immune response immunopathological Inflammation information insight interactions lncRNA microRNA ncRNA ncRNAs non-coding RNA pandemic Research RNA RNA–RNA interactions SARS-CoV-2 severe COVID-19 transcribed Vascular vascular regulation [DOI] 10.3390/ncrna7030054 PMC 바로가기 [Article Type] Review