Immune response to SARS-CoV-2 vaccination in relation to peripheral immune cell profiles among patients with multiple sclerosis receiving ocrelizumab오크렐리주맙을 투여받는 다발성 경화증 환자의 말초 면역 세포 프로필과 관련된 SARS-CoV-2 백신 접종에 대한 면역 반응Article Published on 2022-09-012022-09-12 Journal: Journal of neurology, neurosurgery, and psychiatry [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adverse event analysed antibodies antibody B cell B cell subset baseline Blood Cell-mediated immunity Clinical data Clinical effect clinical trial correlated courses effective facilitate Follow-up humoral immune response identify IFN-γ IgM Immune cell immune response Immunocompromised patient Immunomodulatory therapies interferon long-lasting median multiple sclerosis parameter Patient patients performed peripheral peripheral lymphocyte Plasma cell positive correlation positively correlated preserved profile receiving required Retrospective study SARS-CoV-2 transmission SARS-CoV-2 vaccination SARS-CoV-2 vaccine severe disease T cell response titre titres treatment regimen vaccinate vaccination vaccine dose were assessed were measured [DOI] 10.1136/jnnp-2021-328197 PMC 바로가기 [Article Type] Article
Long COVID symptoms in SARS-CoV-2-positive children aged 0-14 years and matched controls in Denmark (LongCOVIDKidsDK): a national, cross-sectional studyArticle Published on 2022-09-012022-10-04 Journal: The Lancet. Child & adolescent health [Category] COVID19(2023년), SARS, 임상, [키워드] absence acute phase age age and sex children clinically clinics conducted Control control group controls COVID cross-sectional defined Denmark Descriptive statistics develop difference emotional female foundation greater had more Health Hedge higher odd infected with SARS-CoV-2 intensity inventory IQR life Logistic regression analysis Long long-lasting male median mother National Older outcome PCR test positive Prevalence prevalent Psychological Quality Quality of life question Registered response SARS-COV-2 infection SARS-CoV-2 test sick Somatic statistically significant Symptom Symptoms were used [DOI] 10.1016/S2352-4642(22)00154-7 PMC 바로가기 [Article Type] Article
Impact of the COVID-19 Pandemic on Korean Adolescents’ Mental Health and Lifestyle FactorsResearch article Published on 2022-09-012022-10-05 Journal: The Journal of adolescent health : official public [Category] 진단, [키워드] Adolescent adolescents affected analyses Analysis Behavior caused changes in Cohort collected conducted coronavirus disease COVID-19 COVID-19 outbreak COVID-19 pandemic cross-sectional Depression depressive determine Effect emotional Factor Future ideation Impact Internet Korean KYRBS Lifestyle factors long-lasting mental health National pandemic Perceived stress physical activity levels Research Result Satisfaction Suicide survey thought Youth [DOI] 10.1016/j.jadohealth.2022.05.020 [Article Type] Research article
Immunological memory to SARS-CoV-2 infection and COVID-19 vaccinesArticle Published on 2022-09-012022-11-15 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 진단, [키워드] acute infectious disease adaptive immune system adenoviral vectors anatomical antibodies antibody B cells CD4 T cells CD8 T cells cellular cellular component coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines cross-sectional develop Extraordinary feature Head-to-head comparison help Hybrid immunity immune memory Infection infections knowledge long-lasting memory memory B memory B cells memory T memory T cells mRNA mRNA vaccines natural immunity other diseases protective immunity Protein protein vaccine provided Quantitative responses SARS-CoV-2 SARS-COV-2 infection Vaccine Vaccines [DOI] 10.1111/imr.13089 PMC 바로가기
A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severityObservational Study Published on 2022-08-302022-10-05 Journal: Nature Communications [Category] 바이오마커, 임상, 진단, 치료법, [키워드] age Bilirubin Biomarker Brain C-reactive protein chronic fatigue syndrome Cohort Coronavirus disease 2019 COVID-19 evaluate fatigue ferritin Germany hand healthy hemoglobin Inflammation laboratory parameter long-lasting male median age Mild moderate MOST N-terminal Non-COVID-19 pandemic Pathomechanisms Patient patients peptide Postinfectious prohormone prospective observational cohort prospective observational study severe fatigue severity subset Symptom symptom burden symptom severity syndrome [DOI] 10.1038/s41467-022-32507-6 PMC 바로가기 [Article Type] Observational Study
Post-COVID-19 Parkinsonism and Parkinson’s Disease Pathogenesis: The Exosomal Cargo HypothesisArticle Published on 2022-08-282022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] accompanied acute respiratory syndrome aggregation alpha-synuclein Brain cargo cascades caused clinical manifestation clinical manifestations complex contributing to Coronavirus disease 2019 Coronavirus-2 correlation COVID-19 Diagnosis disease disease severity Dopaminergic neuron Evidence Exosome Exosomes Extracellular host protein Infection Inflammation Inflammatory Inflammatory mediators Intercellular communication long-lasting modulated molecular neurodegeneration neurodegenerative Neuroinflammation neurological Parkinson’s disease parkinsonian Parkinsonism Pathogenesis pathophysiological conditions pathway phenotype Pneumonia post-COVID-19 Post-infection prevalent promoter Protein reflected SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA similarity substantia Symptoms syndrome Transmission Viral proteins virus [DOI] 10.3390/ijms23179739 PMC 바로가기
Facing the Omicron variant-how well do vaccines protect against mild and severe COVID-19? Third interim analysis of a living systematic reviewArticle Published on 2022-08-242022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] 95% CI acute respiratory syndrome Against approved booster booster dose booster vaccination characterized coronavirus coronavirus disease COVID-19 COVID-19 vaccine Critical death dominant variant Effectiveness estimate European evaluated Evidence Hospitalization ICU admission Immunity immunization indicated Infection interim analysis long-lasting Mild moderate omicron Omicron variant outcomes Participants performed PROTECT ranged receiving remained risk of bia robust SARS-CoV-2 SARS-COV-2 infection searched severe COVID-19 study heterogeneity symptomatic systematic review the SARS-CoV-2 union vaccination Vaccine vaccine effectiveness variant variant of concern website [DOI] 10.3389/fimmu.2022.940562 PMC 바로가기
Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results Research Published on 2022-08-152022-10-05 Journal: Nature Medicine [Category] 변종, 유전자 메커니즘, 임상, 치료법, [키워드] Adenovirus adverse event analyses Analysis benefit Biomarker CD8 T cell circulating Colorectal cancer Combination CPI diarrhea disease DNA dose Endpoint fatigue feasibility feasible Heterologous immune inhibitor injection site pain Ipilimumab limit long-lasting mRNA Musculoskeletal nivolumab Patient phase 1 trial primary endpoint Pyrexia randomized studies reactivity regimen responses Safe Safety secondary solid tumor statistical survival therapy Tolerability toxicities transaminase translational Tumor vaccination Vaccine viral particle were assessed [DOI] 10.1038/s41591-022-01937-6 [Article Type] Research
Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses Research Published on 2022-08-092022-10-05 Journal: Nature Communications [Category] 유전자 메커니즘, 치료제, [키워드] Antigen antigenic conserved cross-reactive immune response development effective elicit evaluate expressing Generation influenza B Influenza virus lineages long-lasting low dose messenger mice morbidity morbidity and mortality mRNA nucleoside-modified mRNA pentavalent platform PROTECT Protective reducing RNA single vaccination Support tested Vaccine vaccine candidate vaccine candidates vaccine platform virus [DOI] 10.1038/s41467-022-32149-8 [Article Type] Research
Neutralization activity of sera/IgG preparations from fully BNT162b2 vaccinated individuals against SARS-CoV-2 Alpha, Beta, Gamma, Delta, and Kappa variantsSARS-CoV-2 Alpha, Beta, Gamma, Delta 및 Kappa 변이체에 대한 BNT162b2 백신을 완전히 접종한 개인의 혈청/IgG 제제 중화 활성Article Published on 2022-08-082022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료제, [키워드] (alpha administration Alpha antiviral activity approach Beta BNT162b2 BNT162b2 vaccine caused change COVID-19 pandemic Delta delta variant Effectiveness examined fraction Gamma General Hospital IgG individual Influenza influenza vaccines Japan Kumamoto long-lasting Moderation mRNA mRNA-based vaccine mutable Neutralizing activity of BNT162b2 pandemic Pathogens Prospective Study purified reduced reduction respond SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant sera vaccinated individual Vaccine variant variants wild-type SARS-CoV-2 Wuhan [DOI] 10.1038/s41598-022-17071-9 PMC 바로가기 [Article Type] Article