Identification of doxorubicin as a potential therapeutic against SARS-CoV-2 (COVID-19) protease: a molecular docking and dynamics simulation studiesArticle Published on 2022-10-012022-11-16 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, [키워드] 6LU7 amino acid residue Analysis analyzed Antibiotics Antiviral antiviral drugs AutoDock binding energy caused complex complexes conducted COVID-19 COVID-19 disease COVID-19 pandemic docking Doxorubicin drug drug target host cell identification in silico in viral inhibit Interaction lowest MDs molecular docking Molecular dynamics simulation Prevent protease Protease inhibitor remained Replication residue RMSD RMSF SARS-CoV-2 Scientific community Simulation study stability suggested therapeutic virus [DOI] 10.1080/07391102.2021.1905551 PMC 바로가기
Six-month humoral and cellular immune response to the third dose of BNT162b2 anti-SARS-CoV-2 vaccine in patients with solid tumors: a longitudinal cohort study with a focus on the variants of concernArticle Published on 2022-10-012022-11-15 Journal: ESMO open [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 Anti-spike antibody BNT162b2 BNT162b2 anti-SARS-CoV-2 vaccine BNT162b2 vaccine booster Cancer cancer patient cell-mediated immune Cellular immune response Concentration COVID-19 delta variant dose evaluated follow-up period highest highlight Hospitalization humoral Immunoglobulin Infection interferon-γ interquartile range longitudinal cohort study lowest median Messenger RNA Neutralizing Neutralizing activity neutralizing antibody of BNT162b2 omicron Oxygen therapy Patient positive response reduced reduction in required SARS-CoV-2 serum Seven solid tumor subject the SARS-CoV-2 third dose Treatment triggering Vaccine variant variants of concern VOCs were measured were used whole blood sample wild-type strain [DOI] 10.1016/j.esmoop.2022.100574 PMC 바로가기
SARS-CoV-2 antibody responses before and after a third dose of the BNT162b2 vaccine in Italian healthcare workers aged ≤60 years: One year of surveillanceArticle Published on 2022-09-302022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Anti-spike anti-spike antibody BNT162b2 BNT162b2 vaccine booster Cohort correlated domain dose eight evaluated faster group HCWs healthcare worker humoral Humoral response IMPROVE Italian lowest mean value mRNA BNT162b2 vaccine Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer Neutralizing titer no difference participant Pfizer/BioNTech RBD reached representing SARS-CoV-2 SARS-CoV-2 antibody response second dose significantly study groups Surveillance two groups Vaccine vaccine dose [DOI] 10.3389/fimmu.2022.947187 PMC 바로가기
Evolving trend change during the COVID-19 pandemicArticle Published on 2022-09-202022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] African caused country COVID-19 COVID-19 pandemic death disease driving early stage Epidemics epidemics evolve epidemiological Europe Factors feasibility First wave Geographic distribution highest indicated Infection initial Lineage lowest omicron pandemic Prevent provide public health public health measures reducing reduction in severity single vaccine South America spatiotemporal Spread spread of COVID-19 Structure the disease the vaccine Transmissibility vaccination vaccination rate Vaccinations Vaccine variant variants [DOI] 10.3389/fpubh.2022.957265 PMC 바로가기
Seroconversion and outcomes after initial and booster COVID-19 vaccination in adults with hematologic malignanciesArticle Published on 2022-09-152022-11-15 Journal: Cancer [Category] 진단, [키워드] active malignancy analyzed antibodies antibody association Asymptomatic booster booster dose booster vaccination Cancer coronavirus coronavirus disease Coronavirus disease-19 Course COVID-19 COVID-19 infection COVID-19 vaccination COVID-19-related death death decrease detectable diagnosed died effective eliminated Hematologic malignancy high-risk population humoral Humoral immunity immunization incidence of COVID-19 Infection initial lack less lowest lymphoma malignancy monoclonal antibody occurred outcome outcomes Patient postvaccination promote Prophylactic proportion reduced response to vaccination revaccination risk risk of COVID-19 Seroconversion seroconversion rate Serologic response seronegative suggested the patient therapy treated Treatment undetectable vaccination Vaccine [DOI] 10.1002/cncr.34354 PMC 바로가기
SARS-CoV-2 Seroprevalence Study in Pediatric Patients and Health Care Workers Using Multiplex Antibody ImmunoassaysArticle Published on 2022-09-142022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] Adults affected antibody Antigen Beta children circulating Clinical characteristics Cohort correlation COVID-19 delta variant disease ELISA estimate exacerbated False positive Gamma group HCW Health healthcare healthcare worker Healthcare workers highlight hospitals IgA IgA response IgG IgM indicated Infection isotype lowest Luminex assay Mild nucleocapsid PIMS-TS positive correlation RBD recruited SARS-CoV-2 SARS-CoV-2 proteins sensitivity Seropositivity Seroprevalence significantly lower Spain Spanish specificity study period the receptor-binding domain variants were measured worker [DOI] 10.3390/v14092039 PMC 바로가기
Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infectionsArticle Published on 2022-09-132022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] age Analysis association Beta Breakthrough infection breakthrough infections children conducted COVID-19 cycle threshold declined Delta demonstrated Effect Epidemiology highest Immunity incidence increase individual individuals Infection infections investigated lowest PCR random Regression Reinfection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Sex Symptom tested Travel vaccination Vaccine vaccine doses variant variants [DOI] 10.3389/fimmu.2022.984784 PMC 바로가기
Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and FunctionalityArticle Published on 2022-09-042022-11-15 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] activity aggregation ameliorated anti-inflammatory activity Autoimmune disease carboxymethyllysine (CML) cascade caused cholesterol CIGB-258 (Jusvinza) CML co-injection coronavirus disease COVID-19 cytokine Cytokine storm death death rate decrease developmental Efficacy Embryo enhancement exhibited faster ferrous ion Final HDL Heat shock high-density high-density lipoproteins (HDL) highest Hsp60 hyperinflammation infiltration Inflammation Inflammatory inflammatory cells infliximab inhibit injected injection kDa Ligand lipoprotein lowest mechanism neutrophil Pain paralysis Particle peptide plasma protective effect Protein resulting stability Stress Survivability systemic inflammation tissue treated Triglyceride was tested zebrafish [DOI] 10.3390/ijms231710130 PMC 바로가기
Serological Response and Clinical Protection of Anti-SARS-CoV-2 Vaccination and the Role of Immunosuppressive Drugs in a Cohort of Kidney Transplant PatientsArticle Published on 2022-09-022022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] administration antibody antibody response rate Antibody titer Breakthrough infection clinical Cohort conducted COVID-19 COVID-19 vaccination dose drug enrolled evaluate evaluated first dose IgG Immunosuppression immunosuppressive Immunosuppressive treatment incidence kidney transplant kidney transplant recipient lowest mRNA vaccine Patient positive Prevent protection Protective rate of seroconversion recipient recipients regimen regimens reported response retrospective cohort study role SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 second dose serological serological response significantly Solid solid organ transplant study period Transplant vaccination Vaccine vaccine dose Vaccines [DOI] 10.3390/v14091951 PMC 바로가기
Behavior, social and economic impact of COVID-19 responses among healthcare professionals: Development and validation of COVID-19 Responses Impact Questionnaire (COVRiQ)Article Published on 2022-09-012022-11-16 Journal: Nursing & health sciences [Category] SARS, 변종, [키워드] Affect Alpha Analysis analyzed assistant Behavior component construct validity coronavirus COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 responses cumulative deleted demonstrated develop development draft Efficiency evaluate expected Exploratory factor analysis Final healthcare Healthcare professional healthcare professionals higher impact highest Impact impacts indicate internal internal consistency involved Likert scale lowest methodological pandemic participant Participants psychometric property question questionnaire reliability response retained risk SARS-CoV-2 scored SPSS tested Validity variants was measured [DOI] 10.1111/nhs.12965 PMC 바로가기