Lung epithelial cells – Page 3 – Communicable Diseases Research

Induced pluripotent stem cell-based disease modeling and prospective immune therapy for coronavirus disease 2019

Review

Published on 2021-09-142023-06-15
Journal: Cytotherapy
[Category] MERS, SARS,

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응

Research Article

Published on 2021-09-022022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 유전자 메커니즘,

[키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article

Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2

SARS-CoV-2에 감염된 인간 폐 상피 세포의 차등 숙주 circRNA 발현 프로필

Article

Published on 2021-09-012022-09-11
Journal: Infection, genetics and evolution : journal of mol
[Category] 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis binding cause cell death Circular circular RNA coronavirus coronavirus disease COVID-19 death down-regulated dysregulated enrichment analysis epithelial epithelial cell epithelial cells expression pattern expression profile function functions Gene Expression Gene ontology genomic highly pathogenic Host host immune responses human lung human lung epithelial cells immune immune responses Immunity implicated in viral indicated infected with SARS-CoV-2 Infection Inflammatory responses involved KEGG Lung epithelial cells miRNAs mRNA stability network analysis Ontology parental Pathogenesis performed Proteins regulate regulated RNA RNA binding protein RNA-Seq RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly up-regulated viral pathogenesis Virus-host interactions
[DOI] 10.1016/j.meegid.2021.104923 PMC 바로가기 [Article Type] Article

AHR signaling is induced by infection with coronaviruses

Article

Published on 2021-08-262022-10-04
Journal: Nature Communications
[Category] MERS, SARS, 치료제,

[키워드] activate activated Activation AhR Analysis antagonist antiviral immunity antiviral response antiviral therapy Aryl hydrocarbon receptor association boost common cold contribute coronavirus Coronaviruses COVID-19 pandemic COVID-19 patients decrease Dengue epithelial cell evade evaluate expression Future HCoV-229E Host Human illnesses immune response in vitro in vivo increased expression Infection Infectious diseases life-threatening limit Lung epithelial cells Lung pathology lung tissue Medical research Mild pathology pharmacological promote Replication Respiratory failure respiratory tract restrict RNA viruses SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 replication severity Signaling single-cell RNA-seq suppressed targets transcriptional Viral load viral replication viral titer Zika
[DOI] 10.1038/s41467-021-25412-x PMC 바로가기 [Article Type] Article

SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial Cells

SARS-CoV-2 분리주는 인간 면역 세포에서 손상된 복제를 보여주지만 폐 상피 세포에서 복제하고 타고난 면역을 유도하는 차등 능력을 보여줍니다

Research Article

Published on 2021-08-112022-09-10
Journal: Microbiology Spectrum
[Category] MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Calu Calu-3 cell calu-3 cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines dendritic cells epithelial epithelial cells Finnish Gene Expression HCoV Human human cell human cells human DC human lung human macrophage IFN IFNs Immune cell immune cells Impaired induce infect Infection Inflammatory response Inflammatory responses information Innate Innate immunity interferon interferon (IFN) response interferon response interferons interferons (IFNs interferons (IFNs) isolate isolates knowledge lung epithelial cell Lung epithelial cells Lymphocytes macrophages mechanism Monocytes open organ pandemic Pathogenesis pathogenesis of SARS-CoV-2 regulate Regulation replicate replicated Replication respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus show Spread target organ TPCK-treated trypsin type I Type III IFN Vero E6 cell viral replication
[DOI] 10.1128/Spectrum.00774-21 PMC 바로가기 [Article Type] Research Article

Endothelial cell infection and dysfunction, immune activation in severe COVID-19

내피 세포 감염 및 기능 장애, 심한 Covid-19에서의 면역 활성화

Research Paper

Published on 2021-07-062022-09-10
Journal: Theranostics
[Category] MERS, SARS, 진단, 치료기술,

[키워드] Activation adhesion alveolar septa animals body weight Body weight loss Brain infection cadherin cause Cell circulation Coagulation collected complement conducted contribute correlated COVID-19 COVID-19 disease COVID-19 patients cytokine Deceased develop downregulation dysfunction edema electron microscopy endothelial Endothelial cell endothelial cells Endotheliitis Eosinopenia epithelial cells evidenced fatality hemorrhage ICAM1 immune activation Immune cell immune cells immunostaining infect Infection initial Injury interstitial inflammation K18 K18-hACE2 lung Lung epithelial cells Lungs lymphocytopenia mice Microscopy NHP NHP models organ organs Pathogenesis pathway Pathways Patient perivascular inflammation Platelet Platelets Pneumonia pulmonary PULMONARY VESSELS rationale Result RNA-seq analyses SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe COVID-19 disease severity Signaling Single Cell up-regulation upregulated Vascular VCAM1 VE-cadherin vessel weight loss while
[DOI] 10.7150/thno.61810 PMC 바로가기 [Article Type] Research Paper

SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation

RIG-I 및 MDA5에 의한 SARS-CoV-2 감지는 상피 감염을 대식세포 염증과 연결합니다

Article

Published on 2021-07-022022-09-10
Journal: The EMBO Journal
[Category] MERS, SARS, 유전자 메커니즘,

[키워드] Activation airway airway epithelial cell airway epithelial cells cause Cell cellular activation COVID‐19 cytokine cytokine production cytoplasmic develop disease downstream effective ENhance epithelial epithelial cell epithelial cells exacerbate exacerbated human macrophage immunology immunopathological induce Infection Inflammation Inflammatory inflammatory mediator Inflammatory mediators inflammatory state inflammatory stimuli inhibiting innate immune pathway innate immune pathways innate immune response Local lung epithelial cell Lung epithelial cells lung epithelium Macrophage macrophage activation macrophages MDA5 mechanism mediators Microbiology, Virology & Host Pathogen Interaction mitigate Pathways produced replicate required RNA RNA sensing robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 stimulate triggering
[DOI] 10.15252/embj.2021107826 PMC 바로가기 [Article Type] Article

Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators

런트 관련 전사 인자 1을 표적으로 하여 폐 섬유증을 예방하고 중증 급성 호흡기 증후군의 발현을 감소시킵니다 코로나바이러스 2 숙주 매개체

Article

Published on 2021-07-012022-09-12
Journal: The American journal of pathology
[Category] MERS, 신약개발, 진단,

Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry

Article

Published on 2021-06-262022-10-28
Journal: Viruses
[Category] COVID-19, SARS,

[키워드] activities acute infection acute respiratory syndrome anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity antimicrobial peptides Antiviral antiviral activity binding blocked blocking Cell contribute COVID-19 disease Critical defensin Defensins Effect epithelial cells exhibited expressing Factor form hACE2 had no HNP1 Human Immunity Infection inhibited Innate innate immune intestinal investigated linear Lung epithelial cells MERS Middle East neutrophil outcomes Paneth cells peptide peptides Post-infection precursor protective effect provided pseudotyped virus replication-competent SARS-CoV-2 reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike proteins SARS-CoV-2 variants severity spike receptor-binding domain syndrome the disease viral entry viral infection virion virus virus titer β-defensin
[DOI] 10.3390/v13071246 PMC 바로가기 [Article Type] Article

TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2

Article

Published on 2021-06-172023-07-01
Journal: Cellular signalling
[Category] SARS,

[키워드] ACE2 ACE2, angiotensin-converting enzyme 2 COVID-19, coronavirus disease 19 IFN-γ receptor IFNGR, Interferon gamma receptor IRFs, IFN-regulatory factors Lung epithelial cells NK cells NK, natural killer SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 TMPRSS2, Transmembrane serine protease 2 TRIM, Tripartite motif containing TRIM28 ZNF, Zinc finger protein
[DOI] 10.1016/j.cellsig.2021.110064 PMC 바로가기 [Article Type] Article