Low-dose belimumab for patients with systemic lupus erythematosus at low disease activity: protocol for a multicentre, randomised, double-blind, placebo-controlled clinical trialProtocol Published on 2022-02-012024-09-04 Journal: Lupus science & medicine [Category] 대상포진, [키워드] Biological products lupus erythematosus systemic Therapeutics [DOI] 10.1136/lupus-2021-000638 PMC 바로가기 [Article Type] Protocol
B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomised, double-blind, placebo-controlled trialSystemic Lupus Erythematosus Published on 2022-01-062024-09-04 Journal: Annals of the rheumatic diseases [Category] 대상포진, [키워드] lupus erythematosus lupus nephritis rituximab systemic [DOI] 10.1136/annrheumdis-2021-220920 PMC 바로가기 [Article Type] Systemic Lupus Erythematosus
An Imaging and Computational Algorithm for Efficient Identification and Quantification of Neutrophil Extracellular Traps호중구 세포외 트랩의 효율적인 식별 및 정량화를 위한 이미징 및 계산 알고리즘Article Published on 2022-01-062022-09-11 Journal: Cells [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome Algorithm analyses Analysis Annexin Apoptosis approach Arthritis Asthma Cancer Cell cell death cellomics cells Combination COVID-19 death disease pathology DNA efficient eliminated ELISA ENhance exhibited extracellular trap fixation flow cytometry high content screening identification identify Image imaging immunoblotting impermeable inconsistency increase in Inflammation inhibitor intensities intensity lupus erythematosus Microscopy modulate morphology Multiple Necrosis NET NETosis NETs neutrophil Neutrophil extracellular traps Neutrophils nomenclature non-specific nuclear pathway platform provided quantification respiratory distress rheumatoid arthritis Sepsis single-cell single-cell analysis staining suffered syndrome systemic lupus erythematosus target Therapeutic approach therapeutic approaches [DOI] 10.3390/cells11020191 PMC 바로가기 [Article Type] Article
New Onset Biopsy-Proven Nephropathies after COVID VaccinationCOVID 예방 접종 후 새로운 발병 생검으로 입증된 신병증Article Published on 2022-01-012022-09-11 Journal: American journal of nephrology [Category] 변종, [키워드] abnormality Acute kidney injury Administered appearance benefit causal relationship Cohort common disease Corticosteroid Corticosteroids COVID COVID vaccination COVID-19 vaccine de novo declined determine Diagnosis dose focal segmental glomerulosclerosis followed by glomerular Glomerulopathies glomerulosclerosis Hemodialysis highlight Hospitalized IgA nephropathy immune response immunosuppressants Injury Interstitial nephritis Kidney biopsy lupus erythematosus membranoproliferative glomerulonephritis Membranous nephropathy minimal change disease national health system nephropathy New Onset pandemic Patient patients pharmacovigilance pressure renal renal biopsy renal function renal impairment renal insufficiency SARS-CoV-2 SARS-CoV-2 vaccination severity suggested systemic lupus erythematosus the patient Treatment Trigger Two patient two patients unit vaccination Vaccine Vasculitis [DOI] 10.1159/000523962 PMC 바로가기 [Article Type] Article
Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan전신 자가면역에서 치료적 mTOR 차단: 항바이러스 면역 및 수명 연장에 대한 시사점Review Published on 2021-12-012022-09-11 Journal: Autoimmunity reviews [Category] SARS, 치료제, [키워드] Activation adaptive Adaptive immune response aging Antigen antigen-presenting cell antiviral immunity APC Autoimmunity blockade Cell cell fate characterized clinical Clinical effect clinical trials cognate antigen conserved contraction COVID-19 infection Critical cytokine Cytokines disease Efficacy Engagement ENhance evaluate Evidence expansion extension form Health healthy highlight Immune cell lineage specification in viral Infection Inflammation Influenza Influenza virus innate immune system Lifespan extension Lineage lupus erythematosus Mechanistic target of rapamycin mTOR pathway Plasma cell Plasma cells preliminary evidence pro-inflammatory Protective protective immunity protein complex provide provided Rapamycin receptor reduce regulatory T cells responsiveness shown Sirolimus SLE SLE patient SLE patients subjects systemic systemic lupus erythematosus T cell T cell activation T cell receptor T cells TCR Th17 Treatment Trial vaccination viral infection viral infections [DOI] 10.1016/j.autrev.2021.102984 PMC 바로가기 [Article Type] Review
Immunogenicity, safety and reactogenicity of a heterogeneous booster following the CoronaVac inactivated SARS-CoV-2 vaccine in patients with SLE: a case seriesSLE 환자에서 CoronaVac 비활성화 SARS-CoV-2 백신에 따른 이종 부스터의 면역원성, 안전성 및 반응성: 사례 시리즈Article Published on 2021-12-012022-09-12 Journal: RMD Open [Category] SARS, 진단, [키워드] Autoimmune booster booster dose case sery Cellular immune response CoronaVac country COVID-19 COVID-19 pandemic disease elicited Emergency use heterogeneous heterogenous humoral immune response immunogenicity Immunosuppressed immunosuppressive immunosuppressive medications IMPROVE inactivated Inactivated vaccine inactive initial lupus erythematosus mRNA Patient reactogenicity SARS-CoV-2 vaccination SARS-CoV-2 vaccine SLE Support systemic systemic lupus erythematosus therapy vaccination Vaccine Viral vector Viral vector vaccine [DOI] 10.1136/rmdopen-2021-002019 PMC 바로가기 [Article Type] Article
Symptomatic severe acute respiratory syndrome coronavirus 2 reinfection in a lupus patient treated with hydroxychloroquine: a case report하이드록시클로로퀸으로 치료받은 루푸스 환자에서 증상이 있는 중증급성호흡기증후군 코로나바이러스 2 재감염: 증례보고Case Reports Published on 2021-11-262022-09-10 Journal: Journal of Medical Case Reports [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus African anti-inflammatory function antibody Antiviral black Case report Chloroquine coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detrimental diagnosed episode of explain first episode Hospitalized Humoral immunity hydroxy Hydroxychloroquine IgG antibodies IgG antibody immune response immunomodulatory effect Infection initial Lupus lupus erythematosus Patient Reinfection Research respiratory SARS-CoV-2 serology severe acute respiratory syndrome Coronavirus Spread subsequent symptomatic treated Treatment virus [DOI] 10.1186/s13256-021-03159-9 PMC 바로가기 [Article Type] Case Reports
Efficacy and safety of belimumab in paediatric and adult patients with systemic lupus erythematosus: an across-study comparisonOriginal research Published on 2021-09-162024-09-04 Journal: RMD open [Category] 대상포진, [키워드] B-lymphocytes immune system diseases lupus erythematosus systemic Therapeutics [DOI] 10.1136/rmdopen-2021-001747 PMC 바로가기 [Article Type] Original research
Infection hospitalisation in systemic lupus in Swedenarticle Published on 2021-09-152024-09-02 Journal: Lupus science & medicine [Category] 대상포진, [키워드] antirheumatic agents Epidemiology lupus erythematosus systemic Therapeutics [DOI] 10.1136/lupus-2021-000510 PMC 바로가기 [Article Type] article
SARS-CoV-2 Antibody Isotypes in Systemic Lupus Erythematosus Patients Prior to Vaccination: Associations With Disease Activity, Antinuclear Antibodies, and Immunomodulatory Drugs During the First Year of the Pandemic예방 접종 전 전신 홍반성 루푸스 환자의 SARS-CoV-2 항체 아이소타입: 유행병 첫 해 동안 질병 활성, 항핵항체 및 면역조절 약물과의 연관성Immunology Published on 2021-08-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] a minor Activation activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 albumin all subjects analyzed anti-dsDNA antibodies antibody antibody isotypes Antibody Response antinuclear antibodies antinuclear antibody Arthritis Blood Blood Group BMI Cell cell receptor collected complement Complement activation complement-immunological terms coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 COVID-19-related symptom dose drug Effects ELISA envelope protein exposure to Fever followed by glucocorticoid Hydroxychloroquine IgA IgG IgM Impact include individual Infection interferon investigated isotype longitudinal samples Lupus lupus (SLE) lupus erythematosus minor multiplex neutralization (effect of) neutralizing capacity objective pandemic Patient patients with SARS-CoV-2 PCR-confirmed progression proportion Proteins respiratory Result Rheumatic diseases rheumatologist risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection serological severe acute respiratory syndrome Coronavirus severe SARS severe SARS-CoV-2 SLE SLE patient smoking steroid Steroids subject Swedish Symptom systemic systemic lupus erythematosus the cell Thromboembolism type I interferon use of hydroxychloroquine vaccination were measured women Year [DOI] 10.3389/fimmu.2021.724047 PMC 바로가기 [Article Type] Immunology