Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells인터페론 유능한 포유동물 세포에서 항바이러스 보호를 자극하기 위한 긴 dsRNA 매개 RNA 간섭의 발견 및 사용Article Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Antiviral Antiviral effect antiviral response antiviral responses cell line cells cellular cleaved comparable competent complementary Concentration cornerstone CoV dependent on Dicer dsRNA Evidence explanation expressing fluorescent functional gene targeting generate green fluorescent protein HCoV HCoV-229E human coronavirus human coronaviruses IFN immune defense induce inducer inhibit Interference interferons knockdown Lineage Long long dsRNA mammalian mammalian cell mammalian cells Mediated mRNA pathway platform preventing infection produced protection Protein provide required responsible retained RISC RNA RNA interference RNA-induced silencing complex RNAi RNAi pathway SARS-CoV-2 replication sequence shown significantly siRNA siRNAs stimulate stomatitis suppress therapeutic These cells threshold type I interferon vesicular stomatitis vesicular stomatitis virus viral inhibition virus VSV-GFP [DOI] 10.3389/fimmu.2022.859749 PMC 바로가기 [Article Type] Article
Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: A study involving inbred and outbred mice비표적 COVID-19 유기체에서 SARS-CoV-2 유래 펩타이드의 독성에 대한 조명: 근친교배 및 근친교배 마우스를 대상으로 한 연구Article Published on 2022-05-012022-09-11 Journal: Neurotoxicology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] acetylcholinesterase activated administration alteration animals antidepressant antioxidant anxiolytic applied biochemical Biomarker Brain C57Bl/6 J mice catalase consequence COVID-19 demonstrated depressive dismutase dispersion Effect Environmental Toxicology evaluate evaluated Evidence evidence of exposure to Field test genetic profile greater homeostasis hydrogen hydrogen peroxide Impact Laboratory locomotor maintain male mammalian mechanism memory memory deficit mice natural environments open oxidative stress Pandemic COVID-19 PCA peptide Principal component principal component analysis Protein Proteins provide reactive reduction in Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles sensitivity shedding Spike protein Superoxide Superoxide Dismutase Swiss mice. the Spike the vaccine Therapeutic strategies therapeutic strategy Toxicity Viral [DOI] 10.1016/j.neuro.2022.03.012 PMC 바로가기 [Article Type] Article
High-resolution profiling of MHC II peptide presentation capacity reveals SARS-CoV-2 CD4 T cell targets and mechanisms of immune escapeMHC II 펩티드 제시 능력의 고해상도 프로파일링으로 SARS-CoV-2 CD4 T 세포 표적 및 면역 탈출 메커니즘 밝혀Article Published on 2022-04-292022-09-11 Journal: Science Advances [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] alleles alteration arising CD4 comprehensive analysis effective response epitope High-resolution HLA class II HLA class II alleles Immune escape immune evasion in silico in viral limitation mammalian mass spectroscopy mechanism MHC MHC allele MHC alleles MHC class MHC class II MHC II MHC II alleles Mutation peptide peptides physiological function physiological functions platform Precision provide reduced reveal SARS-CoV-2 SARS-CoV-2 peptide sensitivity silico predictions strain T cell T cells target therapeutic use threat Threats throughput understanding viral strains [DOI] 10.1126/sciadv.abl5394 PMC 바로가기 [Article Type] Article
HYBRiD: hydrogel-reinforced DISCO for clearing mammalian bodiesHYBRiD: 포유류의 몸을 청소하기 위한 하이드로겔 강화 DISCOArticle Published on 2022-04-012022-09-11 Journal: Nature methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] antibody Chest compatibility component components demonstrated dimensions DISCO feature fluorescent hACE2 heterogeneous hybrid immunostaining K18-hACE2 transgenic mice macroscopic mammalian mice nervous system Newborn offer organ organic parvalbumin Protein reporter Research SARS-COV-2 infection solvent three dimensions translational utility Viral viral pathology Visualization [DOI] 10.1038/s41592-022-01427-0 PMC 바로가기 [Article Type] Article
Basic virology of SARS-CoV 2SARS-CoV 2의 기본 바이러스학Review Published on 2022-04-012022-09-11 Journal: Indian journal of medical microbiology [Category] Coronavirus, COVID19(2023년), SARS, 치료법, [키워드] 229E acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus basic bats bind cats Cell cell surface cellular membrane Characteristics clinical manifestation coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID 19 COVID-19 disease envelope Exocytosis followed by fusion Genome genomic genomic RNA global public health helical symmetry HKU1 host cell host cell cytosol hosts human coronaviruses humans Immunological response Infection mammalian membrane MERS MERS-CoV Mild NL63 nucleocapsid OC43 pandemic Pathogenesis pathogenic pathogenic coronavirus positive Protein receptor Receptor binding released RNA genome RNA synthesis S protein SARS CoV SARS CoV-2 SARS-CoV 2 SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread structural proteins the S protein translation transported Vesicle vesicles viral genome viral genomic RNA viral replication virion virions Virology virus [DOI] 10.1016/j.ijmmb.2022.02.005 PMC 바로가기 [Article Type] Review
Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim BladderCOVID-19 모델로 Zebrafish 유충 탐색: 수영 방광에서 SARS-CoV-2 복제 중단 가능성Article Published on 2022-03-112022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료기술, [키워드] abortive infection animal animal model animal models Bath bladder wall bloodstream Brain Cell comparable COVID-19 decrease drug Embryo epithelial cell epithelial cells Evidence evidence of Host human ACE2 immunohistochemistry in some in vitro Infection inoculated interferon lung mammalian microinjection no evidence of organ overexpression pathophysiology Prophylactic SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 RNA several variant several variants similarity swim bladder tested therapeutic type I type I interferon Viral load Viral RNA virus wild-type zebrafish [DOI] 10.3389/fcimb.2022.790851 PMC 바로가기 [Article Type] Article
Neurogenesis and Viral InfectionImmunology Published on 2022-02-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] Activation acute respiratory syndrome Affect animal models Brain Cell cell cycle progression cell death cells Central nervous system coronavirus cortical disease Evidence extrinsic fetal gliogenesis impairment Infection Invasion Local mammalian nervous system neural stem cell neural stem cells Neurogenesis neurological Neuron neurotropic SARS-CoV-2 stem cell Support Zika virus ZIKV [DOI] 10.3389/fimmu.2022.826091 PMC 바로가기 [Article Type] Immunology
Avian Orthoavulavirus Type-1 as Vaccine Vector against Respiratory Viral Pathogens in Animal and HumanReview Published on 2022-02-082022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Adaptive immune response animal avian orthoavulaviruses type-1 expression feature Genes Genome Host hosts Human humans include lack limitation mammalian mammalian cell mammals membrane mitigations strategies offer pre-existing immunity protocol Recombination respiratory Respiratory pathogens robust safety profile transitioned unique Vaccine vaccine antigen Vaccines vector vectors viral pathogen virus [DOI] 10.3390/vaccines10020259 PMC 바로가기 [Article Type] Review
Development of plant-made monoclonal antibodies against viral infectionsReview article Published on 2022-02-012022-10-05 Journal: Current opinion in virology [Category] 비임상, [키워드] addition Anti-viral antibody benefit binding candidate clinical development current development expression vector Fc receptors homogeneity mAb mammalian monoclonal antibody novel offer Pandemics plant unique viral infection [DOI] 10.1016/j.coviro.2021.12.005 [Article Type] Review article
The evolution of powerful yet perilous immune systems강력하지만 위험한 면역 체계의 진화Review Published on 2022-02-012022-09-12 Journal: Trends in immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition benefit complement coronavirus disease COVID-19 cytokine Cytokines Defense Evolution Evolutionary biology example explain Goldilocks help immune responses immune system immunopathological immunopathology individual Infection mammalian natural selection optimality. predict resource responses suffered susceptibility symbiont [DOI] 10.1016/j.it.2021.12.002 PMC 바로가기 [Article Type] Review