Potential prophylactic efficacy of mast cell stabilizers against COVID-19 vaccine-induced anaphylaxisLetters to the Editor Published on 2021-12-132022-11-01 Journal: Clinical and Molecular Allergy : CMA [Category] COVID-19, [키워드] addition Adrenaline allergic reaction anaphylaxis Antibiotics approach cause caused Cell chemical mediator coronavirus disease Coronavirus disease 2019 (COVID-19) Corticosteroid COVID-19 COVID-19 vaccination Dexamethasone drug effective Effectiveness Efficacy Exocytosis Hydrocortisone indicated inhibited mast cell mast cell stabilizer Mast cells pharmacological Potential prescribed medication Prophylactic systemic side effects the vaccine Tranilast vaccination Vaccines [DOI] 10.1186/s12948-021-00162-9 PMC 바로가기 [Article Type] Letters to the Editor
The Pathogenesis of COVID-19 Myocardial Injury: An Immunohistochemical Study of Postmortem BiopsiesImmunology Published on 2021-11-052022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute phase Analysis Apoptosis apoptotic cell arrythmia Autopsy biopsy caspase-1 caspase-9 CD163 collagen control group controls COVID-19 COVID-19 patients COVID-19 sample died edema endothelial Endothelium expression fibrosis heart hearts histological ICAM-1 IHC IL-1β IL-4 IL-6 immunohistochemistry increased expression Injury interstitial invasive involved less local inflammation marker mast cell mechanism monoclonal antibody Mortality Myocardial Myocardial dysfunction myocardial injury Myocardium not differ objective Pathogenesis pathogenesis of COVID-19 pathology pathway Patient performed positive Postmortem rationale Result SARS-CoV-2 significantly staining Surveillance TGF-β TNF-α was performed [DOI] 10.3389/fimmu.2021.748417 PMC 바로가기 [Article Type] Immunology
Mast cell activation symptoms are prevalent in Long-COVID비만세포 활성화 증상은 Long-COVID에서 만연Article Published on 2021-11-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, 유전자 메커니즘, [키워드] Activation age Analysis assessment caused cell activation Control COVID-19 COVID-19 symptoms effective therapy Facebook fatigue females group hyper-inflammation Increased life long-COVID mast cell mast cell activation. Mast cells mechanism pathophysiology Patient prevalent Quality of life recruited reported SARS-COV-2 infection severity subject Support Symptom Symptoms syndrome Treatment underlie [DOI] 10.1016/j.ijid.2021.09.043 PMC 바로가기 [Article Type] Article
Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular CoagulationArticle Published on 2021-10-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] anti-inflammatory action bleeding characterized clinical implication Coagulation Coagulopathy complex consequence coronavirus disease COVID-19 cross-talk Disseminated intravascular coagulation Inflammation inflammatory pathways intravascular coagulation intravenous LPS lung lung damage lung dysfunction management mast cell MCs microthrombi organ dysfunction palmitoylethanolamide Pathogenesis plasma Proinflammatory cytokine reduce reduced Result SARS-COV-2 infection Sepsis serine proteases Therapeutic approach ultramicronized palmitoylethanolamide [DOI] 10.3390/ijms222111388 PMC 바로가기 [Article Type] Article
Basophils and Mast Cells in COVID-19 PathogenesisReview Published on 2021-10-142022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] “cytokine storm” Activation Adaptive immune response Airway inflammation allergic anti-parasitic Antigen antigen-presenting cell basophil basophils boost cell differentiation cells characteristic COVID-19 disease epithelial greater humoral humoral immune responses Hyperinflammatory syndrome immune response inducer Infection Inflammatory innate immune response lung cells mast cell Mast cells memory nasal prognostic protective immunity pulmonary fibrosis reducing reduction SARS-CoV-2 susceptibility Th2 Th2 response the antibody response the disease therapeutic target virus worse prognosis [DOI] 10.3390/cells10102754 PMC 바로가기 [Article Type] Review
The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19Review Published on 2021-09-292022-10-31 Journal: Nutrients [Category] COVID-19, SARS, [키워드] Cell complex COVID-19 de novo synthesis Effect Histamine immune system Immunonutrition implicated investigated mast cell modulation pathophysiology pharmacological prevention of COVID-19 proinflammatory receptor reduce regulate SARS-COV-2 infection targets therapeutic therapy [DOI] 10.3390/nu13103458 PMC 바로가기 [Article Type] Review
Ways to Address Perinatal Mast Cell Activation and Focal Brain Inflammation, including Response to SARS-CoV-2, in Autism Spectrum DisorderReview Published on 2021-08-292022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] ACE2 activated Activation address affected allergens allergies Amygdala angiotensin-converting enzyme 2 anti-inflammatory cytokine approach ASD association Asthma atopic dermatitis autism Autism Spectrum Disorder binding block Brain changes children Comorbidity complicate COVID-19 Cytokines Deceased decreased expression disorder disrupting drug effective electrical Epidemiological study expression flavonoids Focal gestation IL-18 increased expression Inflammation Inflammatory inhibit inhibitor Luteolin mast cell Mast cells microglia mother neurodegenerative neuronal Pathogenesis Patient Perinatal Pregnancy Prevalence Proinflammatory cytokine receptor regulate reported response SARS-CoV-2 Spectrum Stress threshold tissue toxins Treatment triggered virus [DOI] 10.3390/jpm11090860 PMC 바로가기 [Article Type] Review
Pathogenic Mechanisms of Vaccine-Induced Immune Thrombotic Thrombocytopenia in People Receiving Anti-COVID-19 Adenoviral-Based Vaccines: A Proposal항-COVID-19 아데노바이러스 기반 백신을 접종받는 사람들에서 백신 유도 면역 혈전성 혈소판 감소증의 병원성 기전: 제안Immunology Published on 2021-08-132022-09-11 Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘, 진단, [키워드] ACE2 receptor activate adenoviral vectors administration affected amplify antibodies binding blood stream cell activation characterized Combination complexes component endothelia erythrocytes erytrocyte extracellular DNA favor heparin IL-6 immune immune response immune responses individual Infection Inflammatory injection leucocyte life-threatening mandatory mast cell Mast cells mechanism natural antibodies occur pathophysiological mechanism PF-4 PF4 Platelet platelet activation Platelets promote Protein receiving serum IgG spike Spike protein Spread Symptom syndrome thrombocytopenia thrombotic thrombotic event Thrombotic events Thrombotic thrombocytopenia Trigger triggering Vaccine Vaccines vector VITT [DOI] 10.3389/fimmu.2021.728513 PMC 바로가기 [Article Type] Immunology
Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast CellsReview Published on 2021-07-122022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] adjuvant antiviral immune response Autopsy cascade Cell coronavirus disease COVID-19 COVID-19 vaccine cytokine cytokine response Cytokine storm Cytokine storm syndrome died distress Evidence function immune response immune system Impact Inflammation lung mast cell Mast cells medication Organ failure Patient Pulmonary edema Recognition reduce role SARS-CoV-2 severity of COVID-19 storm syndrome the cytokine storm thought thrombosis Treatment Vaccine virus [DOI] 10.3390/cells10071761 PMC 바로가기 [Article Type] Review
Potential mechanisms of anaphylaxis to COVID-19 mRNA vaccinesCOVID-19 mRNA 백신에 대한 아나필락시스의 잠재적 메커니즘Review Published on 2021-06-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 유전자 메커니즘, [키워드] Activation allergic Allergic reactions allergy anaphylactic anaphylaxis antibody Antigen applicability atopic cell activation clinically complement component Contact coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA vaccine COVID-19 vaccine effector cells Genetic glycol Health crisis hydrophilic hypersensitivity in vitro individual individuals less Lipid nanoparticle Lipid nanoparticles marker mast cell Mast cells mechanism messenger Messenger RNA mRNA mRNA vaccine nucleic acid packaged pandemic Pathogenesis Patient PEGylated liposome Polyethylene glycol polyethylene glycol. Polymer Potential predict Predictive Predictive value predisposition Prospective clinical trial public health crisis reaction reactivity risk severe allergic reactions suffered Vaccine vaccine administration vaccine production [DOI] 10.1016/j.jaci.2021.04.002 PMC 바로가기 [Article Type] Review