Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia A Randomized Clinical TrialCOVID-19 폐렴을 가진 입원 환자에서 중증 호흡 부전 또는 사망으로의 진행에 대한 하이 튜터 회복기 혈장의 효과 무작위 임상 시험Randomized Controlled Trial Published on 2021-11-292022-08-13 Journal: JAMA Network Open [Category] MERS, SARS, 임상, [키워드] 1:1 95% CI Adverse adverse events age clinical clinical end point clinical trial Composite control group convalescent plasma convalescent plasma group COVID-19 COVID-19 pneumonia CP and ST CP group CP plus ST CP plus standard therapy death defined did not reduce Effect Efficacy eligible enrolled Enrollment evaluate event experimental group failure finding fraction Glucocorticoids heparin high-titer anti–SARS-CoV-2 CP high-titer CP hospitalized patient hospitalized patients Importance infused intravenous IQR Italy Low–molecular weight heparin maximum measure mechanical ventilation Microneutralization test moderate to severe moderate to severe COVID-19 pneumonia modified intention-to-treat not significantly different objective occurred Odds ratio Open-label oxygen partial pressure participant Patient patients patients with COVID-19 patients with moderate plasma Pneumonia Point primary end point Primary outcome progression randomization randomized clinical trial randomized patient receive recommendations Registration Relevance Remdesivir respiratory Respiratory failure Result setting Severe COVID-19 pneumonia severe respiratory failure ST alone standard care Standard therapy the median treat treated Trial Volume volume of infused CP with COVID-19 worsening worsening respiratory failure [DOI] 10.1001/jamanetworkopen.2021.36246 PMC 바로가기 [Article Type] Randomized Controlled Trial
What effect might border screening have on preventing the importation of COVID-19 compared with other infections? A modelling study국경 검역이 다른 감염과 비교하여 COVID-19의 수입을 방지하는 데 어떤 영향을 미칠 수 있습니까? 모델링 연구Original Paper Published on 2021-11-022022-09-11 Journal: Epidemiology and Infection [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome addition Admission average Border Compliance condition coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 cases decrease detect disease disease outbreak Ebola Ebola virus effective Effectiveness Epidemiology Fever Incubation period infected with COVID-19 Influenza International maximum nation outbreak pandemic predominant preventing disease PROTECT public health question reduction in respiratory risk SARS screening programme Severe acute respiratory syndrome symptoms prior the disease Travel undergo while [DOI] 10.1017/S0950268821002387 PMC 바로가기 [Article Type] Original Paper
Symptomatic post-vaccination SARS-CoV-2 infections in healthcare workers- A multicenter cohort studyObservational Study Published on 2021-11-012022-10-05 Journal: Diabetes & metabolic syndrome [Category] SARS, 임상, [키워드] 95%CI Apollo break Break through infections Breakthrough infection case-control study clinical clinical parameter Cohort COVID COVID-19 COVID-19 vaccination COVID-19 vaccine death evaluated examined group healthcare healthcare worker Healthcare workers hospital Hospitalization inactivated India Infection infections maximum Mild multicenter cohort study Nursing occurred Occurrence provided recombinant reducing retrospective SARS-CoV-2 SARS-COV-2 infection severe disease severity Sex significant difference significantly lower symptomatic symptomatic infection symptomatic SARS-CoV-2 infection vaccination Vaccine vaccine dose Vaccines Vero Cell virion were given [DOI] 10.1016/j.dsx.2021.102306 PMC 바로가기 [Article Type] Observational Study
Impact of metabolic and cardiovascular disease on COVID-19 mortality: A systematic review and meta-analysisReview article Published on 2021-11-012022-10-05 Journal: Diabetes & metabolic syndrome [Category] SARS, 바이오마커, [키워드] cardiovascular disease Clinical outcome Comorbidity COVID-19 COVID-19 patients COVID-19 severity Critical database Diabetes Mellitus disease eligible estimate fatal COVID-19 fatal disease higher risk highlight hypertension Impact Lung disease maximum Meta-analysis Mortality Patient Presence Prevalence prevalent random-effects model Result risk SARS-CoV-2 systematic review was done [DOI] 10.1016/j.dsx.2021.102308 [Article Type] Review article
Reciprocal circulation pattern of SARS-CoV-2 and influenza viruses during the influenza seasons 2019/2020 and 2020/2021 in the Bavarian Influenza Sentinel (Germany)바이에른 인플루엔자 센티넬(독일)의 인플루엔자 시즌 2019/2020 및 2020/2021 동안 SARS-CoV-2 및 인플루엔자 바이러스의 상호 순환 패턴Original Paper Published on 2021-10-262022-09-11 Journal: Epidemiology and Infection [Category] MERS, SARS, 치료기술, [키워드] Acute respiratory infection acute respiratory infections analysed average Chain Reaction circulation collected Community COVID-19 COVID-19 pandemic detectable Germany Influenza influenza A Influenza virus influenza viruses maximum oropharyngeal swab oropharyngeal swabs Outpatient outpatients overlapped pandemic polymerase chain polymerase chain reaction positive positive rate predominant provided real-time polymerase chain reaction Reciprocal respiratory RT-PCR SARS-CoV-2 SARS-CoV-2 RNA sentinel Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Spread Surveillance Swab swabs tested Victoria lineage virus Wuhan Wuhan, China [DOI] 10.1017/S0950268821002296 PMC 바로가기 [Article Type] Original Paper
Optimal control strategies on COVID-19 infection to bolster the efficacy of vaccination in IndiaArticle Published on 2021-10-112022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 치료기술, 치료법, [키워드] basic reproduction number carried country COVID-19 COVID-19 disease COVID-19 infection determine Diseases Effect Efficacy Health India individual Infection infective introduced mathematical Mathematics and computing maximum Measures novel parameter principle reducing required sensitivity analysis Transmission Transmission dynamics Treatment vaccination vaccination rate Variation [DOI] 10.1038/s41598-021-99088-0 PMC 바로가기 [Article Type] Article
A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the Remote Early Detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trialSARS-COV-2 감염 (COVID-RED)의 원격 조기 발견을위한 일일 증상 일기 외에 웨어러블 장치의 효과를 조사하기위한 전향 적, 무작위, 단일 맹장, 크로스 오버 시험 : 연구의 구조적 요약.무작위 제어 시험을위한 프로토콜Update Published on 2021-10-112022-09-01 Journal: Trials [Category] MERS, SARS, 임상, 진단, 치료기술, 치료제, [키워드] 1:1 addition adhere Algorithm Algorithms all subject all subjects among others analysed antibody Antibody testing antibody tests Antigen antigen tests approach asked assigned Asymptomatic asymptomatic individual asymptomatic infection average baseline blinded Blinding can not capillary blood Chain Reaction changes in Characteristics cholinergic urticaria Cohort collected Complete conditions conducted consent form contribute control condition COVID-19 COVID-19 infection COVID-19 vaccination current Daily defined demographics described detect detection determine develop deviation diary dissemination Early detection element eligibility criteria eligible End enrolled enrolment evaluate exclusion exploratory feedback Follow-up followed by gold gold standard Health health resource heart rate incidence rates Inclusion inclusion criteria individual individuals infected individual infected individuals infected with SARS-CoV-2 Infection information Informed consent informed consent form initial involved Laboratory laboratory-confirmed SARS-CoV-2 infection machine learning management maximum media medical history Mobile application must nasal swab National natural infection Negative predictive value Netherland Netherlands notification NPV number objective occur outcome pacemaker parameter participant PCR PCR test PCR tests physiological physiological parameters polymerase chain polymerase chain reaction populations portal positive Positive predictive value PPV pre-symptomatic Predictive value primary analysis profession proportion Prospective protocol provided public health Pulse rate questionnaire randomization randomization sequence Randomized Randomized controlled trial Randomly receive recommendation recruited recruitment reduce remote reported resident resource responsible resulting risk RIVM Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 test SARS-CoV-2 virus sensitivity sequence sequence 1 Sequence 2 sequences serology serology test serology tests significantly skin temperature Smartphone social media specificity staff stratified stratified block randomization study participation Study protocol subject suffering supplementary material Symptom Symptom diary Symptoms target temperature test result tested the SARS-CoV-2 thought Transmission transmissions Trial Trial registration undergo urticaria used to evaluate vaccinated against COVID-19 vaccination Vaccine Variability wearable device website Well-being [DOI] 10.1186/s13063-021-05643-5 PMC 바로가기 [Article Type] Update
A New Transmuted Generalized Lomax Distribution: Properties and Applications to COVID-19 DataResearch Article Published on 2021-10-072022-10-31 Journal: Computational Intelligence and Neuroscience [Category] Coronavirus, MERS, SARS, [키워드] application bootstrap Characteristics Complete confidence interval COVID-19 demonstrated distribution distributions Features flexible form France Generalized include introduced likelihood maximum New Other parameter property real-world data Rényi entropy Research United Kingdom utility [DOI] 10.1155/2021/5918511 PMC 바로가기 [Article Type] Research Article
Computer-aided prediction of inhibitors against STAT3 for managing COVID-19 associated cytokine stormCOVID-19 관련 사이토 카인 폭풍 관리를위한 STAT3에 대한 억제제의 컴퓨터 보조 예측Article Published on 2021-10-012022-08-31 Journal: Computers in biology and medicine [Category] 신약개발, [키워드] Accuracy Activation aromatic group aromatic groups AUC best build correlated COVID-19 COVID-19 pathogenesis COVID-19 patients cytokine Cytokine storm Cytokines Data analysis dataset develop drug FDA-Approved FDA-approved drug FDA-approved drugs identify inhibitor inhibitors lead machine learning classifier machine learning classifiers maximum outcome patients with COVID-19 Perindopril predict Predictive model predictive models proinflammatory cytokines Proinflammatory response proliferate second Severity of disease signaling pathway significantly STAT3 Tamoxifen the cytokine storm [DOI] 10.1016/j.compbiomed.2021.104780 PMC 바로가기 [Article Type] Article
Prevalence and Transmission of Severe Acute Respiratory Syndrome Coronavirus Type 2 in Childcare Facilities: A Longitudinal Study보육 시설에서 중증 급성 호흡기 증후군 코로나 바이러스 유형 2의 유병률 및 전파: 종단 연구Multicenter Study Published on 2021-10-012022-09-11 Journal: The Journal of pediatrics [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Adults analyzed Asymptomatic Chain Reaction children coronavirus COVID-19 demographic characteristics driving enrolled evaluate Evidence evidence of Infection information knowledge longitudinal longitudinal study maximum pandemic parent parents participating children polymerase chain polymerase chain reaction Preschool preschool. Prevalence respiratory Sample SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 virus secondary case seropositive Seroprevalence Spread Stool study period study population the SARS-CoV-2 Transmission Type virus [DOI] 10.1016/j.jpeds.2021.07.054 PMC 바로가기 [Article Type] Multicenter Study