MDs – Page 3 – Communicable Diseases Research

Pharmacophore Modelling-Based Drug Repurposing Approaches for SARS-CoV-2 Therapeutics

Chemistry

Published on 2021-05-102022-10-31
Journal: Frontiers in Chemistry [Category] COVID-19,

Myelodysplastic syndrome in a 30-year-old man with coronavirus disease 2019 (COVID-19): a diagnostic challenge

Clinical Case Report

Published on 2021-04-232022-10-27
Journal: Autopsy & Case Reports [Category] COVID-19,

[키워드] addition Affect Analysis bilateral pneumonia Bone marrow cells chills clinical evaluation Combination condition coronavirus disease coughing COVID-19 COVID-19 patients Cytogenetics cytopenia demonstrated diagnosed Diagnosis diagnostic Dizziness dysplastic feature Fever flow cytometry hospital Hospitalization immunohistochemistry individual male management MDs Mild mimicking moderate molecular molecular feature Mutation Myelodysplastic syndrome myelodysplastic syndromes myelofibrosis neutrophil occur pathologic Patient patients patients with COVID-19 Peripheral blood raised reactive repeated reported SARS-CoV-2 Sequencing SF3B1 Shortness of breath subsequent weakness
[DOI] 10.4322/acr.2021.274 PMC 바로가기 [Article Type] Clinical Case Report

Mediterranean diet and the risk of COVID-19 in the ‘Seguimiento Universidad de Navarra’ cohort

Research article

Published on 2021-04-012022-10-05
Journal: Clinical nutrition (Edinburgh, Scotland) [Category] COVID19(2023년), SARS, 진단,

[키워드] 95% confidence interval adherence association average baseline biological plausibility Cohort COVID-19 cumulative diagnostic diet dietary intake Effect exhibited expected Food habit Frequency Health Health professionals healthy highest immune system Interaction knowledge lower risk lowest MDs Mediterranean diet multivariable logistic regression Odds ratio participant Participants positive COVID-19 positive result professional professionals prospective cohort questionnaire remained repeated reported Result risk risk of COVID-19 robust SARS-COV-2 infection score Sensitivity analyses significantly lower Spain statistical analysis subgroup were assessed women
[DOI] 10.1016/j.clnu.2021.04.001 [Article Type] Research article

Repurposing of some anti-infective drugs for COVID-19 treatment: A surveillance study supported by an in silico investigation

COVID-19 치료를 위한 일부 항감염제의 용도 변경: in silico 조사에 의해 뒷받침되는 감시 연구

Article

Published on 2021-04-012022-09-11
Journal: International journal of clinical practice [Category] SARS, 신약개발, 치료기술, 치료제,

[키워드] AAK1 added Admission ADP-ribose anti-infective drug antimicrobial Antimicrobials applied Azithromycin binding binding free energy binding mode binding modes Clinical finding Clinical findings clinical outcomes Combination Compound computational studies Computational study COVID-19 death detect diarrhoea docked docking experiment docking experiments docking score doxycycline drug effective Efficacy enrolled explain females four groups free energy Free energy calculations group IMPROVE in silico in vitro inhibitors intensive care kinase lead MDs Mild mild to moderate moderate Moderate COVID-19 moderate symptoms molecular molecular dynamic simulations nitazoxanide not seen outcomes phosphatase Protein target replacement reported repurposing required Reverse transcription-polymerase chain reaction ribose starting point subject subjects supported Surveillance Symptom symptomatic improvement therapeutic potential treated treating COVID-19 Treatment turn Viral
[DOI] 10.1111/ijcp.13877 PMC 바로가기 [Article Type] Article

Immunoinformatic approach to design a multiepitope vaccine targeting non-mutational hotspot regions of structural and non-structural proteins of the SARS CoV2

Bioinformatics

Published on 2021-03-232022-10-28
Journal: PeerJ [Category] COVID-19,

[키워드] 3D structure Analysis Antigen antigen processing antigenicity approach B cell binding affinity binding energy calculated caused Cell complex coronavirus 2 cross-reactivity database demonstrated docking envelope protein epitope Epitopes evaluated Extracellular high mortality HLA host cell hotspot IFN immune response Immune simulation induce Infection injection interacting residue Interaction leukocyte linker MDs Membrane proteins memory Microbiome Molecular dynamics simulation morbidity multiepitope vaccine Mutation mutations non-structural protein ORF1ab polyprotein ORF3a protein ORF8 protein outbreak pandemic Physicochemical properties predicted Protein proteomics Region respiratory Result SARS CoV2 screened selected sensitivity Seven similarity strong immune response Study design Surface glycoprotein T cell the vaccine TLR TLRs Toll-like receptor Toxicity vaccination Vaccine vaccine construct virus was performed
[DOI] 10.7717/peerj.11126 PMC 바로가기 [Article Type] Bioinformatics

Multivalent Display of SARS-CoV-2 Spike (RBD Domain) of COVID-19 to Nanomaterial, Protein Ferritin Nanocages

Article

Published on 2021-02-172022-10-28
Journal: Biomolecules [Category] COVID-19, MERS,

[키워드] ACE2 ACE2 receptor Alter Analysis binding Cell chimeric coronavirus spike protein COVID-19 death develop display displaying effective ferritin ferritin nanocage FIVE fusion protein host receptor human Angiotensin-converting enzyme human host hydrogen bonds in silico Interaction internalization linker MDs molecular dynamic simulation Molecular dynamics simulation molecular target multivalent occur Protein Protein–protein interaction protein–protein interaction Quality of life RBD RBD binding receptor Receptor-binding domain (RBD) Region Safe SARS-CoV-2 significantly spike stability subunit Surface glycoprotein tested the receptor-binding domain the spike protein trimeric Vaccine Vaccine development virus virus transmission
[DOI] 10.3390/biom11020297 PMC 바로가기 [Article Type] Article

Novel cyclohexanone compound as a potential ligand against SARS-CoV-2 main-protease

SARS-CoV-2 메인 프로테아제에 대한 잠재적 리간드로서의 새로운 사이클로헥사논 화합물

Article

Published on 2020-12-012022-09-11
Journal: Microbial pathogenesis [Category] SARS, 치료제,

De novo design, retrosynthetic analysis and combinatorial synthesis of a hybrid antiviral (VTAR-01) to inhibit the interaction of SARS-CoV2 spike glycoprotein with human angiotensin-converting enzyme 2

Research Article

Published on 2020-10-152022-10-27
Journal: Biology open [Category] COVID-19,

[키워드] De novo designing ACE2 Analysis angiotensin converting enzyme 2 Antiviral antiviral molecule Ascorbate bind binding caused complex COVID-19 disease de novo dependent on docking domain enzyme hACE2 high mortality human Angiotensin-converting enzyme Hybrid antiviral molecule Hydroxychloroquine Infection inhibit interact Interaction MDs molecular Molecular dynamics simulation morbidity outbreak Pathogenesis Protein RBD RBD-ACE2 recognize responsible Retrosynthetic analysis ribavirin SARS-CoV2 SARS-CoV2 spike glycoprotein SARS-like coronavirus spike spike glycoprotein Spike protein tested the receptor-binding domain variant virus were used
[DOI] 10.1242/bio.054056 PMC 바로가기 [Article Type] Research Article

De novo design, retrosynthetic analysis and combinatorial synthesis of a hybrid antiviral (VTAR-01) to inhibit the interaction of SARS-CoV2 spike glycoprotein with human angiotensin-converting enzyme 2

Research Article

Published on 2020-10-152022-10-27
Journal: Biology open [Category] Coronavirus, COVID-19, Fulltext,

[키워드] De novo designing ACE2 Analysis angiotensin converting enzyme 2 Antiviral antiviral molecule Ascorbate bind binding caused complex COVID-19 disease de novo dependent on docking domain enzyme hACE2 high mortality human Angiotensin-converting enzyme Hybrid antiviral molecule Hydroxychloroquine Infection inhibit interact Interaction MDs molecular Molecular dynamics simulation morbidity outbreak Pathogenesis Protein RBD RBD-ACE2 recognize responsible Retrosynthetic analysis ribavirin SARS-CoV2 SARS-CoV2 spike glycoprotein SARS-like coronavirus spike spike glycoprotein Spike protein tested the receptor-binding domain variant virus were used
[DOI] 10.1242/bio.054056 PMC 바로가기 [Article Type] Research Article

Clean Grinding Technique: A Facile Synthesis and In Silico Antiviral Activity of Hydrazones, Pyrazoles, and Pyrazines Bearing Thiazole Moiety against SARS-CoV-2 Main Protease (M pro )

Article

Published on 2020-10-062022-10-30
Journal: Molecules [Category] COVID-19, MERS, SARS,