mechanically ventilated patient – Page 3 – Communicable Diseases Research

Comparison between methylprednisolone infusion and dexamethasone in COVID-19 ARDS mechanically ventilated patients

Research

Published on 2022-02-152022-10-31
Journal: The Egyptian Journal of Internal Medicine [Category] COVID-19,

Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study

Observational Study

Published on 2022-02-012022-10-05
Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 임상,

[키워드] 95% CI Active surveillance acute respiratory distress adjusted age analysed Analysis anti-IL-6 association case report forms collected criteria death Dexamethasone discharge eligible participant enrolled Follow-up French fungal Fungal infection fungal pathogen groups hazard ratio high mortality high risk highlight ICU ICU admission ICUs identify IFI Infection intensive care intensive care unit invasive knowledge mechanical ventilation mechanically ventilated patient mechanically ventilated patients men microorganism Mortality Mucormycosis multicentre Multivariate analysis National Observational cohort study Odds ratio Older outcome Patient performed Pfizer Population Prevalence Primary outcome Registered regression models risk factor Risk factors SARS-COV-2 infection screened secondary severe COVID-19 significantly higher solid organ transplantation survival curve syndrome Treatment variable with COVID-19
[DOI] 10.1016/S2213-2600(21)00442-2 PMC 바로가기 [Article Type] Observational Study

Focus on renal blood flow in mechanically ventilated patients with SARS-CoV-2: a prospective pilot study

Observational Study

Published on 2022-02-012022-10-05
Journal: Journal of clinical monitoring and computing [Category] COVID19(2023년), SARS, 임상,

Prostacyclin in Intubated Patients with COVID-19 and Severe Endotheliopathy: A Multicenter, Randomized Clinical Trial

Randomized Controlled Trial

Published on 2022-02-012022-10-05
Journal: American Journal of Respiratory and Critical Care [Category] 임상, 진단,

Decision support system to evaluate ventilation in the acute respiratory distress syndrome (DeVENT study)—trial protocol

급성 호흡 곤란 증후군에서 환기를 평가하기 위한 의사 결정 지원 시스템(DeVENT 연구) - 시험 프로토콜

Study Protocol

Published on 2022-01-172022-09-10
Journal: Trials [Category] SARS, 임상,

[키워드] acute respiratory distress acute respiratory distress syndrome allocation approach ARDS ARDS patient ARDS patients clinical decision clinical trial complex concealed contribute Course COVID-19 COVID-19 pandemic Critical care Decision support decision support system decision support systems decrease decreases determine determined by driving End-Expiratory Pressure evaluate facilitate help IMPROVE improvement International Local lung Lung injury management mathematical Mathematical models mechanical ventilation Mechanical ventilation; Acute respiratory distress syndrome mechanically ventilated mechanically ventilated patient mechanically ventilated patients Mitigation morbidity morbidity and mortality Mortality occur open outcome pandemic Pandemics Patient patients PEEP personalised physiological state point-of-care Positive end-expiratory pressure Pragmatic pressure protective effect Protective effects protocol randomised reduction in respiratory distress Respiratory distress syndrome routine care severity supplementary material Support Support System syndrome variety ventilated patient ventilated patients Ventilation ventilator Ventilator-induced lung injury ventilatory strategy
[DOI] 10.1186/s13063-021-05967-2 PMC 바로가기 [Article Type] Study Protocol

Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza

박테리아 동시 감염 및 지속적인 호중구 기관지 폐포 염증에 대한 비정형 반응은 인플루엔자와 중요한 COVID-19를 구별합니다

Research Article

Published on 2022-01-112022-09-12
Journal: JCI Insight [Category] 진단, 치료기술,

[키워드] activating Antibiotic treatment Bacterial bacterial coinfections BAL BAL fluid blood sample bronchoalveolar Bronchoalveolar lavage CCL7 chemokine chemokines chemotactic factor circulating Cohort collected comparable Concentration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical Critically ill critically ill COVID-19 patients CXCL1 CXCL11 CXCL12 CXCL8 cytokine Cytokines decrease effector cell elafin elevated fluids G-CSF highlighting IL-1 β IL-17A IL-1ra Immunological response immunology Inflammation Influenza Invasive mechanical ventilation leukocyte lung Lungs Lymphocytes mechanically ventilated patient mechanically ventilated patients metalloproteinase Monocytes neutrophil neutrophilic Neutrophils NK cell NK cells parameter pathophysiology patients with COVID-19 patients with influenza Protease inhibitor protease inhibitors proteolytic activity severe coronavirus disease Tissue Inhibitor TNF- α Treatment Viral pneumonia
[DOI] 10.1172/jci.insight.155055 PMC 바로가기 [Article Type] Research Article

Efficacy of the early treatment with tocilizumab-hydroxychloroquine and tocilizumab-remdesivir in severe COVID-19 Patients

중증 코로나19 환자에서 토실리주맙-히드록시클로로퀸 및 토실리주맙-렘데시비르 조기 치료 효과

Randomized Controlled Trial

Published on 2022-01-012022-09-12
Journal: Journal of infection and public health [Category] 임상, 진단, 치료제,

[키워드] Anti-inflammatory anti-inflammatory drug Antiviral both groups clinical clinical parameter cohort study Combination Complication contributed COVID 19 COVID-19 COVID19 CRP Cytokine storm dimer doses early treatment Effectiveness ferritin groups HCQ Hospitalization Hydroxychloroquine hyper inflammation ICU Infection infused interquartile range IQR laboratory investigation LDH mechanical ventilation mechanically ventilated patient median myocarditis no significant difference P/F PaO Patient PCR Randomized regimen Registered Remdesivir secondary bacterial infection severe COVID-19 significant decrease significantly TCZ Thrombotic events Tocilizumab Treatment treatment groups treatment regimen two group were assessed
[DOI] 10.1016/j.jiph.2021.10.024 PMC 바로가기 [Article Type] Randomized Controlled Trial

Use of mNUTRIC-Score for Nutrition Risk Assessment and Prognosis Prediction in Critically Ill Patients with COVID-19: A Retrospective Observational Study

Research Article

Published on 2021-12-222022-10-31
Journal: Critical Care Research and Practice [Category] COVID-19,

Positive end-expiratory pressure in COVID-19 acute respiratory distress syndrome: the heterogeneous effects

Research

Published on 2021-12-162022-11-01
Journal: Critical Care [Category] COVID-19, SARS,

[키워드] acute respiratory distress Affect age applied ARDS changes in Characteristics collected Compliance COVID-19 dead diagnosis of SARS-CoV-2 driving early phase Effect End-Expiratory Pressure enrolled fraction Gas exchange hemodynamic heterogeneity heterogeneous Hypoxemia investigated Keeping lung lung mechanics Mechanical power mechanically ventilated patient oxygen Oxygenation PaO pathophysiological feature PEEP predicted raising Respiratory distress syndrome Respiratory mechanics respiratory rate Respiratory system Result SARS-CoV-2 selected severity significantly increased Stress subgroup of patient subgroup of patients supplementary material the disease the median variable venous Ventilator-induced lung injury ventilatory Volume
[DOI] 10.1186/s13054-021-03839-4 PMC 바로가기 [Article Type] Research

Extracellular Vesicle Associated miRNAs Regulate Signaling Pathways Involved in COVID-19 Pneumonia and the Progression to Severe Acute Respiratory Corona Virus-2 Syndrome

세포 외 소포 관련 miRNA는 COVID-19 폐렴에 관여하는 신호 전달 경로를 조절하고 심한 급성 호흡기 코로나 바이러스 -2 증후군으로의 진행

Immunology

Published on 2021-12-092022-08-31
Journal: Frontiers in Immunology [Category] SARS, 바이오마커,

[키워드] ACE2 expression activated adjusted alveolar cell among others Analysis analyzed ARDS ARDS patients bind Biomarker Biomarkers carrier carriers Cell cell-free microRNAs cell-to-cell communication cells circulating community acquired pneumonia controls Corona COVID-19 COVID-19 ARDS patient COVID-19 pneumonia CXCL8 Differential gene expression differential gene expression analysis differentially expressed miRNA downregulated epithelial evaluated EVs Extracellular vesicles function group healthy control healthy controls IL6 increase Inflammatory inhibited interleukin interleukin-6 interleukin-8 investigated let-7e-5p log2FC lung Lung diseases mechanically ventilated patient mediators miR-146 miR-146a-5p miRNA miRNAs mRNA mRNA transcript mRNA transcripts nasal epithelium network network analysis neutrophil neutrophil recruitment olfactory OR52N2 pathophysiology Pathways Pneumonia Precipitation prospectively studied receptor regulate regulated respiratory Result resulting RNA sequencing SARS-CoV-2 spike protein secrete Sepsis Severe Acute Respiratory Corona Virus-2 Syndrome severe COVID-19 Signaling signaling pathway significantly small RNA small RNA sequencing Spike protein symptomatic patient syndrome the healthy therapeutic targets TLR4 Toll-like receptor toll-like receptor 4 total RNA transcript upregulated Vesicle with COVID-19
[DOI] 10.3389/fimmu.2021.784028 PMC 바로가기 [Article Type] Immunology