Clinical efficacy and mechanism of mesenchymal stromal cells in treatment of COVID-19Review Published on 2022-02-072022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] affected candidate clinical Clinical efficacy clinical trial Computed tomography Coronavirus disease 2019 COVID-19 Cytokines disease Effect Efficacy Epidemic Health immunomodulation immunomodulatory mechanism Mesenchymal stromal cells Mortality MSC MSCs over Registered stromal cell subsequent Symptom therapy tissue repair Treatment viral infectious disease [DOI] 10.1186/s13287-022-02743-0 PMC 바로가기 [Article Type] Review
Protease Activated Receptors: A Pathway to Boosting Mesenchymal Stromal Cell Therapeutic Efficacy in Acute Respiratory Distress Syndrome?Review Published on 2022-01-242022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] anticipated benefit boost Cell COVID-19 pandemic critically ill patients Defense develop Efficiency effort endothelial ENhance epithelial expressed G-protein growth Host Infection inflammatory condition Lung injury Mesenchymal stromal cell Mesenchymal stromal cells mortality rate MSC MSCs outcomes pharmacological protease activated receptors receptor respiratory Respiratory failure secretion Sepsis Severe case shown Steroids supportive care survival tested therapeutic Therapeutic benefit therapeutic effect translational [DOI] 10.3390/ijms23031277 PMC 바로가기 [Article Type] Review
Direct comparison of different therapeutic cell types susceptibility to inflammatory cytokines associated with COVID-19 acute lung injuryCOVID-19 급성 폐 손상과 관련된 염증성 사이토카인에 대한 다양한 치료 세포 유형 감수성의 직접 비교Research Published on 2022-01-152022-09-10 Journal: Stem Cell Research & Therapy [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome Alter Analysis ARDS ARDS patients Bone marrow Cell Cell therapy cell type cell viability cells characterized clinical evaluation clinical trial clinically Combination conditioned media COVID-19 COVID-19 ARDS patient cytokine Cytokine storm Cytokines Cytometry deleterious effect determine Direct Disease progression dose doses dysregulated immune response evaluate the effect excluded expression Extracellular Extracellular vesicles Flow flow cytometry greater high risk IL-6 immunomodulatory implicated Infection Inflammatory cytokine Inflammatory cytokines inflammatory mediator Inflammatory mediators mediators Mesenchymal stromal cells Mild Mortality not altered Novel coronavirus paracrine pathology Patient pro-inflammatory mediator pro-inflammatory mediators progression proteomic receptor receptors respiratory distress Respiratory distress syndrome Result severe ARDS severe COVID-19 stem cell stem cells stromal cells supplementary material survival susceptibility syndrome the cell therapeutic therapeutic efficacy therapy Treatment umbilical Vesicle viability were assessed widespread with COVID-19 [DOI] 10.1186/s13287-021-02699-7 PMC 바로가기 [Article Type] Research
Editorial: A Compendium of Recent Research on Stem Cell-Based Therapy for Covid-19Cell and Developmental Biology Published on 2021-12-142022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] Advanced therapies CAR T cells Cell therapy clinical trials compendium COVID-19 Cytokine storm immunomodulaion Mesenchymal stromal cells recent STEM [DOI] 10.3389/fcell.2021.813384 PMC 바로가기 [Article Type] Cell and Developmental Biology
Mesenchymal Stromal Cells: Potential Option for COVID-19 TreatmentReview Published on 2021-09-162022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] ARDS Case report Characteristics clinical trial clinical trials COVID-19 COVID-19 pandemic develop feature groups high mortality rate immune reaction immunomodulation impacted indication mechanism of action Mesenchymal stromal cells MSC MSCs multiorgan failure option Potential potential treatment option Respiratory failure Safe Severe COVID-19 pneumonia severe patients Side effect significantly stromal cell targeted therapy therapy Treatment [DOI] 10.3390/pharmaceutics13091481 PMC 바로가기 [Article Type] Review
Mesenchymal stromal cells as a therapeutic intervention for COVID-19: a living systematic review and meta-analysis protocolCovid-19에 대한 치료 중재로서의 중간 엽 기질 세포 : 살아있는 체계적인 검토 및 메타 분석 프로토콜Protocol Published on 2021-09-152022-08-31 Journal: Systematic Reviews [Category] COVID-19, meta-analysis, SARS, [키워드] activated acute respiratory distress syndrome adverse event adverse events ARDS benefit Case series characterization Clinical outcome clinical study Community concerning conditioned media Controlled controlled trials Coronavirus disease 2019 COVID-19 CRD data extraction database determine Efficacy Evidence Exosomes extracellular vesicle Extracellular vesicles global pandemic Health Health policy immune response immune responses immunomodulatory information Isolation Laboratory lack life-threatening Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells meta-analyses Meta-analysis Microvesicles Mild MSC MSCs non-randomized outcomes pandemic Patient patient population performed Pneumonia populations protocol random-effect random-effects Random-effects meta-analysis Randomized real time SARS-CoV-2 SARS-COV-2 infection secreted Secretome Sepsis severe acute respiratory syndrome coronavirus 2 stromal cells subsequent supplementary material systematic literature search systematic review therapeutic intervention tissue repair treat trials [DOI] 10.1186/s13643-021-01803-5 PMC 바로가기 [Article Type] Protocol
Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized controlled double-blind phase II clinical trial (The NOMA Trial)혈관재생 가능성이 없는 위독한 사지 허혈이 있는 당뇨병 환자에서 동종 지방 조직 유래 및 확장 중간엽 기질 세포의 근육내 투여의 효능 및 안전성: 무작위 대조 이중 맹검 2상 임상 시험을 위한 연구 프로토콜(The NOMA Trial)Study Protocol Published on 2021-09-062022-09-10 Journal: Trials [Category] SARS, 비임상, 임상, [키워드] adipose Adipose tissue Adipose-derived mesenchymal stromal cells Administered administration Advanced therapy medicinal products adverse event adverse events Allogeneic Angiogenesis animal model animal models antiplatelet assigned breath Cell Cell therapy chronic clinical development Clinical practice clinical trial control group Critical Critical limb ischemia current data set demonstrated develop diabetes Diabetes Mellitus diabetic patient dose double-blind Efficacy eligible patient evaluate evaluated feasibility Health Organization health problem humans IMPROVE induce intramuscular Ischemia life limb lower limb Mesenchymal stromal cells multicenter outcome parameters Patient Phase II clinical trial placebo-controlled trial Primary outcome protocol public health Quality of life Randomized Randomly Registration Research revascularization secondary Secondary outcomes shown statins step stromal cell stromal cells study period Study protocol Tertiary the disease therapeutic therapeutic option therapeutic options therapy tissue tissue perfusion Treatment treatment group Trial registration type 2 diabete Type 2 diabetes mellitus World Health Organization [DOI] 10.1186/s13063-021-05430-2 PMC 바로가기 [Article Type] Study Protocol
Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19?Review Published on 2021-07-272022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, [키워드] acute respiratory distress syndrome Analysis Antiviral candidate caused Cell therapy Cell-based therapy clinical evidence complement complications COVID-19 COVID-19 cases COVID-19 pandemic Critical deaths Efficacy elevated Healthcare system immunomodulatory knowledge limitations Local mechanism Mesenchymal stromal cell Mesenchymal stromal cells mortality rate MSCs multiple organ involvement Novel coronavirus occurred pandemic pathophysiological Pneumonia reduce SARS-CoV-2 Spread therapeutic therapeutic strategy Therapies therapy [DOI] 10.1186/s13287-021-02502-7 PMC 바로가기 [Article Type] Review
The immune modulatory effects of umbilical cord-derived mesenchymal stromal cells in severe COVID-19 pneumoniaShort Report Published on 2021-06-022022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, MERS, SARS, [키워드] accompanied addition assays baseline bronchoalveolar cellular chemokine circulating circulating monocyte Coronavirus disease 2019 COVID-19 Cytokines decrease effective ELISA Exploratory analysis flow cytometry functional immune modulatory effect immune reaction immunological immunomodulatory property immunosuppressive Infection Inflammatory inflammatory neutrophils Inflammatory response intensive care unit interleukin-6 life-threatening low-density Mesenchymal stromal cells MSC MSCs myeloid cells neutrophil neutrophil recruitment Patient Peripheral blood plasma Pneumonia pro-inflammatory cytokines pro-thrombotic reduction renal scRNA-seq Serum level severe COVID-19 Severe COVID-19 pneumonia Single-cell RNA sequencing stromal cell supplementary material T lymphocyte treated Treatment Trial tumor necrosis factor-α umbilical were assessed [DOI] 10.1186/s13287-021-02376-9 PMC 바로가기 [Article Type] Short Report
Mesenchymal stromal cell delivery via an ex vivo bioreactor preclinical test system attenuates clot formation for intravascular applicationArticle Published on 2021-06-012023-06-19 Journal: Stem cells translational medicine [Category] MERS, SARS, [키워드] bioreactor clot formation time clotting COVID-19 Ex vivo heparin hypercoagulable IBMR instant blood-mediated inflammatory reaction Mesenchymal stromal cells Perfusion [DOI] 10.1002/sctm.20-0454 PMC 바로가기