A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic optionsArticle Published on 2022-09-012022-11-16 Journal: Science China. Life sciences [Category] SARS, 유전자 메커니즘, [키워드] acetyl-CoA Activation alteration analyzed anti-inflammatory function CLYBL combating Control convert COVID-19 COVID-19 patients COVID-19 progression COVID-19 samples Critical Defense enzyme healthy controls Host host protein Human identify immune modulatory Immunity increase in Inflammation itaconate Macrophage metabolism metabolite moderate modulating observation pathway Pneumonia Protein proteome proteomes proteomic regulated RNA virus SARS-CoV-2 viruses severe symptom signaling pathway suggested TCA cycle the disease therapeutic option therapeutic target treating COVID-19 Urine worsening [DOI] 10.1007/s11427-021-2070-y PMC 바로가기
Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort studyResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] absence adverse outcomes analysed approach assigned Biomarker Biomarkers Classifier CLEC6A Clinical improvement Clinical outcome Clinical use Cohort cohorts collected complex complications Course COVID-19 COVID-19 pandemic Critical cytokine Cytokines dataset defined development disease disease severity disorder domain Eric ether example finding funding high variability hospital Hospital admission independent Lipid lipids machine Machine learning algorithms marker Mayo Clinic metabolite metabolites molecular MOST multidimensional outcome participant Patient patients with COVID-19 plasma plasma sample positive predict predicted Predictive producing Protein Proteins proteomics proximity extension assay quantified reported representing retrospective cohort study SARS-CoV-2 RT-PCR severity subgroup subset Tandem mass spectrometry the WHO USA was done with COVID-19 [DOI] 10.1016/S2589-7500(22)00112-1 [Article Type] Research article
Antiviral drugs against influenza: Treatment methods, environmental risk assessment and analytical determinationReview article Published on 2022-09-012022-10-05 Journal: Journal of environmental management [Category] 치료제, [키워드] addition Adsorption Antiviral antiviral drug Antiviral drugs against influenza approach biological processes Characteristics Coagulation Combined Concentration concentrations contaminant Contamination COVID-19 drug Ecotoxicological risk Effect Effects evaluated filtration indicated Influenza investigated metabolite metabolites over Perspective plant Prevent required Research risk tested Toxicity Treatment Wastewater treatment were assessed [DOI] 10.1016/j.jenvman.2022.115523 [Article Type] Review article
Visual diagnosis of COVID-19 disease based on serum metabolites using a paper-based electronic tongueResearch article Published on 2022-09-012022-10-05 Journal: Analytica chimica acta [Category] 진단, 치료기술, [키워드] Accuracy age Array-based sensor calculated caused chemometrics collected colorimetric detection complexes Compound Concentration Control control sample correlation COVID-19 COVID-19 disease COVID-19 patient diagnosis of COVID-19 disease Diseases element human serum information men and women metabolite metabolomics PCR test point-of-care rapid detection response resulting serum serum sample severity statistical the disease tongue Variation viral infection Viral load Visual [DOI] 10.1016/j.aca.2022.340286 [Article Type] Research article
The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implicationsArticle Published on 2022-08-312022-11-15 Journal: Biochemical Journal [Category] 진단, [키워드] activities amyloid microclots antioxidants biochemical burst Capillaries cell activation conditions COVID disease element Evidence explain hyperinflammation hypoxia implication Inflammatory diseases initiated Injury involved ischaemia–reperfusion injury. Long Long COVID malaise marker mechanism mechanisms metabolite Occurrence oxidative stress pathology produced reactive oxygen specy relapsing reperfusion rheumatoid arthritis Safe therapeutic Therapeutic benefit variety [DOI] 10.1042/BCJ20220154 PMC 바로가기
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients코로나19 환자 뇌 감염의 형태적, 세포적, 분자적 기초Article Published on 2022-08-302022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration anxiety symptoms Astrocyte astrocytes biogenesis Brain brain damage Brain infection brain tissue brains cellular changes in characterized Cohort contribute coronavirus cortical Cortical atrophy COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients death deregulated died dysfunction elicit energy metabolism Evidence exhibited fatigue FIVE foci functional genetic material guide histopathological sign histopathological signs Hypothesis impairment in vitro independent individual infect infected individual Infection Interaction manifestation manifested mechanism metabolism metabolite metabolites mild infection molecular basis neural stem cell Neurological symptoms neuronal neurons Neuropsychiatric Neurotransmitters NRP1 Patient phenotype Protein reduce Replication SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection Spectrum Support Supporting susceptible syndrome tissue sample viability virus [DOI] 10.1073/pnas.2200960119 PMC 바로가기 [Article Type] Article
A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular EntryArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome all-trans retinoic acid analogue antibody antiviral activity Apoptosis ATRA bind binding Cell cellular cellular entry Compound coronavirus Coronaviruses COVID-19 derivative disease Efficacy etiological agent feasibility global pandemic growth human cell line hydrophobic pocket include inhibitory Interaction Interrupting life-threatening coronavirus disease Lower respiratory tract mechanism metabolite organ systems Organoid pharmacological physiological prevention of COVID-19 RBD Receptor binding domain regulate reported retinol S trimer SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Spike protein structural mechanism. the SARS-CoV-2 therapeutic trimer Vaccine vitamin A [DOI] 10.1128/mbio.01485-22 PMC 바로가기
Integrated microbiome and metabolome analysis reveals the potential therapeutic mechanism of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumoniaArticle Published on 2022-08-262022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] 유전자 메커니즘, [키워드] 16S rRNA addition affected amino acids Analysis bile acids change China Clinical treatment coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 current Eicosanoids evaluated fatty acids Gut gut microbiota Host Host immune response immune immune function immune response IMPROVE Inflammation lipid metabolism lung tissue mechanism metabolism metabolite metabolome metabolomic analysis mice Microbiome modulating patients with COVID-19 performed Pneumonia Qing-Fei-Pai-Du decoction reduce reveal Sequencing serum severity shown significantly Spearman correlation analysis Staphylococcus therapeutic therapeutic effect Treatment was performed [DOI] 10.3389/fcimb.2022.950983 PMC 바로가기
Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study Research Published on 2022-08-262022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] acute respiratory distress ARDS Bacterial infection Biomarker Biomarkers both groups change circulating circulation Clinical characteristics conducted control patient correlated Critically ill defined differential expression differentially expressed distress evaluate heterogeneous identify intensive care patients metabolite metabolomics microRNA MicroRNAs miRNA miRNA expression morbidity and mortality non-coding RNA pathophysiological Patient pediatric Pediatric patient Pediatric patients pilot study prognostic biomarker progression prospective cohort study provide Random forest random forest classification responsible risk selected single-center sub-cohort subset syndrome therapeutic intervention [DOI] 10.1038/s41598-022-15476-0 [Article Type] Research
Combining metabolome and clinical indicators with machine learning provides some promising diagnostic markers to precisely detect smear-positive/negative pulmonary tuberculosis대사체와 임상 지표를 기계 학습과 결합하면 도말 양성/음성 폐결핵을 정확하게 감지하는 몇 가지 유망한 진단 마커를 제공합니다.Article Published on 2022-08-252022-09-11 Journal: BMC Infectious Diseases [Category] Coronavirus, 바이오마커, 치료기술, [키워드] Amino acid Analysis best Biomarker Biomarkers cause Characteristics Combination conducted Control controls COVID-19 death death case death cases detect Diagnosis diagnostic diagnostic biomarker Diagnostic biomarkers discriminant analysis dysfunction enriched pathways fatty Fatty acid feature global pandemic high accuracy Infectious disease machine machine learning marker metabolisms metabolite metabolome metabolomic metabolomic analysis metabolomic profiling metabolomics Mycobacterium tuberculosis Mycobacterium tuberculosis (Mtb) offer Patient patients performed plasma Precision provide pulmonary tuberculosis R package random Random forest Seven significant enrichment smear Smear-positive/negative pulmonary tuberculosis Support SVM TB patient three group three groups Tuberculosis Tuberculosis (TB) was performed [DOI] 10.1186/s12879-022-07694-8 PMC 바로가기 [Article Type] Article