Methylene Blue has a potent antiviral activity against SARS-CoV-2 and H1N1 influenza virus in the absence of UV-activation in vitro메틸렌 블루는 시험 관내 UV- 활성화의 부재하에 SARS-COV-2 및 H1N1 인플루엔자 바이러스에 대한 강력한 항 바이러스 활성을 갖는다.Article Published on 2021-07-122022-09-01 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 진단, 치료제, [키워드] absence Activation addition antiviral activity Antiviral agents approved blood product blood products blue Cell Clinical studies clinical study Concentration Degradation drug effective EMA European Medicines Agency evaluated examined FDA food genomic RNA H1N1 H1N1 influenza immune Immune Serum in vitro infected with SARS-CoV-2 Influenza influenza virus H1N1 malaria mechanism methemoglobinemia Methylene Methylene blue presence or absence safety profile SARS-CoV-2 SARS-CoV-2 infections serum shown Support therapeutic activity therapeutic efficacy Treatment UV light viral infection virucidal virus viruses [DOI] 10.1038/s41598-021-92481-9 PMC 바로가기 [Article Type] Article
In Vitro Evaluation of the Antiviral Activity of Methylene Blue Alone or in Combination against SARS-CoV-2Article Published on 2021-07-062022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activity acute respiratory syndrome antimalarial drug Antiviral antiviral drug blue Cell Chloroquine clinically Combination Concentration coronavirus coronavirus disease COVID-19 Effect effective Hydroxychloroquine identifying in vitro investigated median Methylene Methylene blue Post-infection Remdesivir retrieved RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain Side effect Spread Stage Support treat Treatment Vero E6 cell viral entry viral replication Wuhan, China [DOI] 10.3390/jcm10143007 PMC 바로가기 [Article Type] Article
Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasmaCOVID-19 회복기 혈장의 면역학적 특성에 대한 병원체 감소 방법의 영향Article Published on 2021-07-012022-09-12 Journal: Vox Sanguinis [Category] SARS, 진단, [키워드] Amotosalen collected comparison convalescent convalescent plasma COVID-19 COVID-19 convalescent donor COVID-19 convalescent plasma decrease dose greater Immunoglobulin immunological Impact initial likelihood material Methylene blue N-protein Neutralizing activity neutralizing antibody NtAbs pathogen Pathogen reduction plasma provide RBD reduced reduction remained Riboflavin riboflavin. SARS-CoV-2 SARS-CoV2 specific antibody statistically significant titre Treatment virus were measured [DOI] 10.1111/vox.13056 PMC 바로가기 [Article Type] Article
New methylene blue derivatives suggest novel anti-orthopoxviral strategiesArticle Published on 2021-07-012023-06-10 Journal: Antiviral Research [Category] Fulltext, 원숭이두창, [키워드] Antiviral Methylene blue Novel inhibitor PAV-866 poxviruses vaccinia virus [DOI] 10.1016/j.antiviral.2021.105086 PMC 바로가기
Effects of distancing and pattern of breathing on the filtering capability of commercial and custom-made facial masks: An in-vitro study거리와 호흡 패턴이 상업용 및 맞춤형 안면 마스크의 필터링 기능에 미치는 영향: 체외 연구Research Article Published on 2021-04-222022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, [키워드] airway breathing Combination Comparisons conditions COVID-19 defined distance Effect emitter expressed facial facial masks finding fraction In-vitro individuals inhalation Inhaled jet nebulizer less lung mannequin Mask Masks Methylene Methylene blue nebulized Pandemics Prevent primary endpoint PROTECT significant effect solution Spectrophotometry surgical tested Transmission user were used while [DOI] 10.1371/journal.pone.0250432 PMC 바로가기 [Article Type] Research Article
Methylene blue photochemical treatment as a reliable SARS-CoV-2 plasma virus inactivation method for blood safety and convalescent plasma therapy for COVID-19메틸렌 블루 광화학 치료는 코로나19에 대한 혈액 안전 및 회복기 혈장 치료를 위한 신뢰할 수 있는 SARS-CoV-2 혈장 바이러스 비활성화 방법으로Research Article Published on 2021-04-162022-09-01 Journal: BMC Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] adjusted AIDS asymptomatic infection Blood blood product blood products Blood safety blood transfusions cells change clinical trial clinical trials Concentration Convalescent plasma therapy coronavirus COVID-19 COVID-19 cases Culture declined Effect Efficiency Final HIV treatment HIV-1 illumination Inactivated Vaccines inactivation infect Lipid Live virus Lower respiratory tract Lux median Methylene Methylene blue New coronavirus outbreak PCR photochemical Photochemical treatment plasma Plasma transfusion Plasma virus inactivation Quantitative recovering patients respiratory Result reverse transcription risk room temperature Safe SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus strain Spread TCID50 temperature the SARS-CoV-2 therapy tissue tissue culture transfusion Treatment university upper or lower respiratory tract virus virus inactivation virus RNA virus titer viruses was used were measured Zhejiang [DOI] 10.1186/s12879-021-05993-0 PMC 바로가기 [Article Type] Research Article
Antiviral photodynamic therapy: Inactivation and inhibition of SARS-CoV-2 in vitro using methylene blue and RadachlorinArticle Published on 2021-03-012023-07-11 Journal: Photodiagnosis and photodynamic therapy [Category] SARS, [키워드] antiviral Photodynamic therapy COVID-19 Methylene blue Radachlorin SARS-CoV-2 [DOI] 10.1016/j.pdpdt.2020.102112 PMC 바로가기
Methylene Blue Inhibits the SARS-CoV-2 Spike–ACE2 Protein-Protein Interaction–a Mechanism that can Contribute to its Antiviral Activity Against COVID-19Pharmacology Published on 2021-01-132022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] absence ACE2 ACE2-expressing cell activated activity Against Antiviral antiviral activity approved blood product blue Chloroquine Compound contribute coronavirus COVID-19 COVID-19 pandemic Critical Erythrosine B FDA half-maximal inhibitory concentration identify inactivation Inhaled inhibit inhibited inhibitor inhibitory activity initiated Interaction medication Methylene Methylene blue PPI protein-protein interaction pseudovirus receptor ACE2 responsible SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein shown Spike protein Suramin the SARS-CoV-2 Treatment virus [DOI] 10.3389/fphar.2020.600372 PMC 바로가기 [Article Type] Pharmacology
Methylene blue in covid-19코로나19의 메틸렌 블루Article Published on 2021-01-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome administration anti-cytokine Antiviral antiviral drug antiviral drugs bilateral pneumonia Blood Cell COVID-19 Cytochine storm cytokine Cytokine storm Cytokines disease Disease progression drug Efficacy explained Free Free radicals Infection inflammatory reaction inhibit involved malaria mediators mediators of inflammation methaemoglobinaemia Methylene Methylene blue Mortality multi-organ failure nitrogen oxygen Pneumonia Prevent produced reactive reactive oxygen respiratory respiratory distress Respiratory distress syndrome respiratory tract responsible SARS-CoV-2 SARS-COV-2 infection Septic shock serious complication syndrome the disease tissue damage treat triggered urinary tract infections Viral viral spread virus [DOI] 10.1016/j.mehy.2020.110455 PMC 바로가기 [Article Type] Article
Methylene blue inhibits replication of SARS-CoV-2 in vitroArticle Published on 2020-12-012023-07-05 Journal: International journal of antimicrobial agents [Category] SARS, [키워드] Antiviral coronavirus COVID-19 in vitro Methylene blue SARS-CoV-2 [DOI] 10.1016/j.ijantimicag.2020.106202 PMC 바로가기