Serum β 2 -microglobulin levels in Coronavirus disease 2019 (Covid-19): Another prognosticator of disease severity?코로나바이러스 질병 2019(Covid-19)의 혈청 β 2 -마이크로글로불린 수준: 질병 중증도의 또 다른 예후 인자?Observational Study Published on 2021-03-012022-09-10 Journal: PLoS ONE [Category] 바이오마커, 임상, [키워드] accompanied Admission age ANOVA test Arabian Peninsula Care circulation Cohort confirmation conformation Control controls coronavirus disease Coronavirus disease 2019 disease disease severity disorder domain elevated Ethnicity etiology FIVE hospital Increases increases in infected with SARS-CoV-2 kDa limitation linear MHC MHC class MHC class I microglobulin Mild Mild disease moderate disease on admission outcome Pathogenesis Patient predict Protein protein complex Sample size Saudi Arabia severe COVID-19 severe disease severity Severity of disease Shed single-center study the major histocompatibility uninfected Viral viral infections were measured WHO [DOI] 10.1371/journal.pone.0247758 PMC 바로가기 [Article Type] Observational Study
Homologies between SARS-CoV-2 and allergen proteins may direct T cell-mediated heterologous immune responsesArticle Published on 2021-02-262022-10-04 Journal: Scientific Reports [Category] MERS, 진단, [키워드] acute respiratory syndrome allergen allergens applied approach approaches Aspergillus fumigatus association bioinformatics class cohorts complementary Computational biology and bioinformatics Coronavirus-2 COVID-19 cross-reactive cross-reactivity de novo epitope Epitopes functional Heterologous homologous immune response immunology in silico investigated involved MHC MHC class outbreak overlapping peptide peptides Phleum predicted Probability Protein proteome public health emergency responses risk factor SARS-CoV-2 sequence T cell epitope T cell epitopes the SARS-CoV-2 [DOI] 10.1038/s41598-021-84320-8 PMC 바로가기 [Article Type] Article
The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR ProteinsReview Published on 2021-01-222022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] Activation addition bind Cancer caspase CIITA complex conserved contributing to differential expression domain Ebola expression functions Gene Expression Gene regulation homolog Immunity inhibitor intrinsic mammalian master regulator MHC MHC class MHC class II MHC genes MHC-I MHC-II NLR NLRC5 NLRP3 Protein Protein–protein interaction Proteins recruitment regulated Regulation the major histocompatibility transcriptional regulation transcriptional regulator virus replication [DOI] 10.3390/ijms22031074 PMC 바로가기 [Article Type] Review
Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approachesSARS-COV-2에 대한 차세대 멀티에피토프 기반 백신(MEV) 설계: 면역정보학 및 인실리코 접근법Research Article Published on 2020-12-222022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] adjuvant Amino acid amino acids analyses antigenic antigenic proteins approach B-cell binding affinity caused conducted coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 demonstrated effective epitope Epitopes Escherichia coli Escherichia coli K-12 system flexible followed by global health security highly antigenic HLA-binding allele HLA-binding alleles human pathogenic toll-like receptors immunogenic profile in silico In silico cloning increased expression indicated K-12 linker MEV MEV codon MEV codons MEV construct MHC class MHC class I MHC class II epitopes molecular molecular docking molecular dynamics multiepitope based vaccine non-allergenic overlapping pandemic pathogenic predicted Protein respiratory Respiratory Coronavirus selected Selected epitopes severe acute respiratory coronavirus significant interaction T-cell target targets Till TLR TLR3 TLR8 Toll-like receptor Vaccine vaccine against SARS-COV-2 vaccine production [DOI] 10.1371/journal.pone.0244176 PMC 바로가기 [Article Type] Research Article
MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronavirusesReport Published on 2020-10-092022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] activating acute respiratory syndrome Antigen presentation Antiviral antiviral activity antiviral therapies canonical cathepsin-dependent CD74 Cell cellular mechanism CIITA complex coronavirus Coronaviruses Defense disease disrupt Ebola Ebola virus endosomal entry endosomal entry pathway expression Factor Filovirus glycoprotein histocompatibility complex Host human cell line human cells identify in viral induce inhibit involved isoform MHC MHC class outbreak Pathogens Prevent Protein recent resistance mechanism restriction factor SARS virus SARS-CoV-2 SARS-like coronavirus Science screening strategy the major histocompatibility therapeutic option transcription factor Treatment viral entry viral infections virus viruses well [DOI] 10.1126/science.abb3753 PMC 바로가기 [Article Type] Report
Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2Short Report Published on 2020-07-102022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, SARS, [키워드] Analysis antigenicity B-cell epitope B-cell epitopes BepiPred binding bioinformatics Bioinformatics analysis Biotechnology candidate caused center characterized component computation database Discontinuous epitope Epitope-based vaccine exhibited feature genome sequence Gln HLA binding IEDB immune Infection MHC class MHC class I NCBI nucleocapsid protein outbreak pandemic peptide predict predicted Pro produced Protective protein sequence public health Rapid residue resource Result retrieved SARS-CoV-2 spike Spike protein surface T-cell epitope Thr Vaccine Vaccine development [DOI] 10.1186/s40249-020-00713-3 PMC 바로가기 [Article Type] Short Report
Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous systemResearch Article Published on 2020-05-252022-11-01 Journal: Glia [Category] Coronavirus, MERS, [키워드] Activation addition Apolipoprotein e CD4+ T cell CD45+ CD86 Cell Central nervous system CNS colony stimulating factor coronavirus Coronavirus infection Coronavirus replication correlated CSF1R cystatin damaged decreased expression Defense demonstrated Demyelination dendritic cells deplete Depletion disease elevated ENhance expressed expression functional growth factor Host host defense impair implicated increase increase in increased mortality Infection inhibitor Macrophage macrophages MHC class mice microenvironment microglia mouse hepatitis virus murine myeloid cell nerve tissue neurologic neurotropic osteopontin PLX5622 Population Protein receptor remyelination RNA sequencing severity susceptible T cell transcript Treatment viral replication [DOI] 10.1002/glia.23844 PMC 바로가기 [Article Type] Research Article
Design of a Multiepitope-Based Peptide Vaccine against the E Protein of Human COVID-19: An Immunoinformatics ApproachResearch Article Published on 2020-05-112022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] 2019-nCoV approach approved binding candidate China city clinically Combination coronavirus disease Coverage COVID-19 determine disease Endemic envelope protein Epidemic Extensive genomic help Human immunogenic immunogenic profile immunoinformatics insertion International MHC class MHC class I multiepitope peptide vaccine mutations Novel coronavirus outbreak Outbreaks peptide Result Sequencing Spread T-cell the disease Treatment Vaccine Vaccine design were used WHO World Health Organization Wuhan [DOI] 10.1155/2020/2683286 PMC 바로가기 [Article Type] Research Article
Design of a Multiepitope-Based Peptide Vaccine against the E Protein of Human COVID-19: An Immunoinformatics ApproachResearch Article Published on 2020-05-112022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] 2019-nCoV approach approved binding candidate China city clinically Combination coronavirus disease Coverage COVID-19 determine disease Endemic envelope protein Epidemic Extensive genomic help Human immunogenic immunogenic profile immunoinformatics insertion International MHC class MHC class I multiepitope peptide vaccine mutations Novel coronavirus outbreak Outbreaks peptide Result Sequencing Spread T-cell the disease Treatment Vaccine Vaccine design were used WHO World Health Organization Wuhan [DOI] 10.1155/2020/2683286 PMC 바로가기 [Article Type] Research Article
A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)게놈 전체에 걸친 통합 게놈 연구는 엡스타인-바 바이러스 핵 항원 1(EBNA-1)에 대한 항체에 영향을 미치는 유전적 요인을 국소화합니다.Research Article Published on 2013-01-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Adult adverse outcome adverse outcomes Analysis antibody antibody levels Antigen approach association Author Autoimmune disorders best Burkitt lymphoma Cancer cancers Candidates chromosome chromosome 6 concerning dataset disease Disease progression DQB1 DRB1 EBV Epstein Barr virus Epstein-Barr virus Evidence evidence of examined expression data Factor family members focus foreign antigen foreign antigens found Gene Gene Expression Genetic genetic factors Genome HLA HLA locus HLA-DQB1 HLA-DRB1 Hodgkin lymphoma Host human leukocyte antigen IgG antibodies IgG antibody immune function immune system independent individual infect Infected Infection infectious Infectious disease infectious mononucleosis investigated involved joint leukocyte linkage loci locus lupus erythematosus lymphocyte lymphoproliferative disorders malignancies malignancy measure mechanism MHC class MHC class II multiple sclerosis nasopharyngeal lymphoma not found nuclear overlap P -value pathogen Pathogens prevalent provide regulate related replicated Research severe complication severe complications severe disease significantly SNP SNPs susceptibility susceptibility loci systemic lupus erythematosus T cells virus was obtained [DOI] 10.1371/journal.pgen.1003147 PMC 바로가기 [Article Type] Research Article