Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU중환자실 외부에서 조기 입원 및 조기 항바이러스 치료를 받은 중증도가 낮은 코로나19 환자의 결과Observational Study Published on 2021-04-302022-09-10 Journal: Turkish Journal of Medical Sciences [Category] SARS, 임상, 치료제, [키워드] Admission Antibody test antiviral therapy Antiviral treatment Azithromycin Care Case fatality rate Case series Clinical data clinically suspected collected Combination COVID-19 COVID-19 adult patient COVID-19 pandemic COVID-19 patient COVID-19 patients diagnosed Diseases duration of hospitalization evaluated Fatality rate Favipiravir hospital hospital ward Hospital wards Hospitalization Hospitalized Hydroxychloroquine hydroxychloroquine plus azithromycin ICU infiltration internal internal medicine Laboratory male management material median median age Medicine microbiologically Mild Mild-to-moderate moderate disease noncritical illness Patient patients patients died PCR radiological finding regimen regimens Result severe pneumonia single-center study Symptom the patient transferred treated university university hospital with COVID-19 [DOI] 10.3906/sag-2006-173 PMC 바로가기 [Article Type] Observational Study
Post-exposure prophylaxis against SARS-CoV-2 in close contacts of confirmed COVID-19 cases (CORIPREV): study protocol for a cluster-randomized trial확인된 COVID-19 사례(CORIPREV)의 긴밀한 접촉에서 SARS-CoV-2에 대한 노출 후 예방: 클러스터 무작위 시험을 위한 연구 프로토콜Study Protocol Published on 2021-03-222022-09-10 Journal: Trials [Category] SARS, 임상, 치료기술, 치료제, [키워드] 1:1 adaptive Analysis approach attack rate baseline Chain Reaction Chemoprophylaxis close contact Cluster Cluster randomization Clusters Combination confirmed COVID-19 case Confirmed COVID-19 infection Contact control arm correlation coefficient Course COVID-19 COVID-19 infection COVID-19 pandemic defined detect Diseases drug early treatment Efficacy epidemiological estimate evaluate excluded exposure to generalized linear mixed model Hospitalization ICC include incorporation individual Infection Infectious diseases Interim analyses interim analysis Intervention intervention arm life linear mixed model logit Lopinavir Lopinavir/ritonavir medication microbiologically modify Mortality multicenter novel Open-label oral lopinavir/ritonavir outcome participant polymerase chain polymerase chain reaction positive Post-exposure prophylaxis Prevent prevention prevention approach primary analysis Primary outcome Probability Prophylaxis protocol psychological Impact Quality of life Randomized controlled trial Registered Relative risk respiratory Respiratory failure respiratory tract risk reduction Ritonavir Safe Sample size sample size calculation SARS-CoV-2 secondary secondary attack rate Secondary outcomes Seropositivity specimen Study protocol study visit subset supplementary material Support switching symptomatic symptomatic COVID-19 Trial Trial registration ventilator [DOI] 10.1186/s13063-021-05134-7 PMC 바로가기 [Article Type] Study Protocol
SARS-CoV-2-reactive interferon-γ-producing CD8+ T cells in patients hospitalized with coronavirus disease 2019코로나바이러스 질병 2019로 입원한 환자의 SARS-CoV-2 반응성 인터페론-γ 생성 CD8+ T 세포Article Published on 2021-01-012022-09-12 Journal: Journal of medical virology [Category] 진단, [키워드] acute respiratory syndrome Amino acid antibody antigenic blood cell count CD4+ CD8+ CD8+ T cell CD8+ T cells CD8+ T-cell Clinical course comparable coronavirus coronavirus disease correlation COVID-19 detectable detection rate determine displaying entire sequence expressing flow-cytometry form Frequency glycoprotein hospitalized patient IFN-γ Immunoglobulin inflammatory biomarkers information intensive care interferon-γ intracellular cytokine staining M protein median microbiologically N-terminal no correlation overlapping Patient patients hospitalized patients with moderate peptide producing prognostic quantitation responses SARS-CoV-2 SARS-COV-2 infection sequence spike subset T-cell T-cell immune response T-cell immunity tested the disease the SARS-CoV-2 were used [DOI] 10.1002/jmv.26213 PMC 바로가기 [Article Type] Article
Lung ultrasound is a reliable diagnostic technique to predict abnormal CT chest scan and to detect oxygen requirements in COVID-19 pneumoniaResearch Paper Published on 2020-10-312022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, [키워드] Abnormalities assessment chest scan COVID-19 CT chest CT scan Daily detect Diagnosis diagnosis of COVID-19 diagnostic dyspneic Evolution Follow-up help high mortality intensive care lung Lung CT Lung Ultrasonography Lung ultrasound microbiologically MONITOR older patients oxygen need Oxygen requirement Oxygen requirements pandemic Patient patients with COVID-19 performed Pneumonia predict Prevalence protocol respiratory RT-PCR Safe [DOI] 10.18632/aging.104150 PMC 바로가기 [Article Type] Research Paper
Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort studyCOVID-19 입원 환자의 동시 감염 및 중복 감염 발생: 후향적 코호트 연구Observational Study Published on 2020-07-312022-09-14 Journal: Clinical microbiology and infection : the official [Category] SARS, 임상, 진단, [키워드] Antimicrobial therapy Bacterial bacterial superinfections Barcelona caused clinic Co-infection Co-infections consecutive patient coronavirus disease COVID-19 COVID-19 diagnosis dead diagnosed Diagnosis discharged Electronic health records Epidemiology Escherichia coli fungal Hospital admission Hospitalization hospitalized patient Laboratory microbiologically Mortality objective Observational cohort study outcome outcomes Pandemics Patient performed Pseudomonas aeruginosa Result retrieved retrospective cohort study SARS-CoV-2 Seven Staphylococcus aureus Streptococcus pneumoniae Superinfections with COVID-19 [DOI] 10.1016/j.cmi.2020.07.041 PMC 바로가기 [Article Type] Observational Study
Protecting Frontline Health Care Workers from COVID-19 with Hydroxychloroquine Pre-exposure Prophylaxis: A structured summary of a study protocol for a randomised placebo-controlled multisite trial in Toronto, CanadaLetter Published on 2020-07-142022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 Activation age All participants anticipated baseline blinded block sizes blocked blood sample Canada Chloroquine circulating cirrhosis clinical clinician composite endpoint computer-generated Concomitant medication correlation Course COVID-19 COVID-19 negative criteria deficiency determine diabete diagnostic disease severity dissemination ECG element Encephalopathy endothelial Enrollment extension FIVE fixed Follow-up G6PD HCQ HCW Health care worker Hepatitis high risk hospital Hospitalization Hospitalized Host Hydroxychloroquine immune include individually randomized insulin intensive care units Intervention intervention arm intubation investigator Laboratory Liver disease Long marker microbiologically Mortality multisite neutralize non-invasive ventilation non-specific number objective offered Older open label Oropharyngeal outcome outcome measure parallel-group participant patients per day Placebo placebo-controlled plasma porphyria positive positive result pregnant Prevent Primary outcome Prophylaxis Protecting protocol Psychological distress psychological Impact QTc QTc interval randomised randomised placebo controlled trial reactive reduce Registered renal reported Research Respiratory failure risk of COVID-19 Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus secondary Seroconversion serology Standard status study period Study protocol Support symptom duration symptomatic syndrome Tablet tablets term Toronto Trial two group Two-arm undergo use of hydroxychloroquine ventilator viral PCR Viral RNA website worker [DOI] 10.1186/s13063-020-04577-8 PMC 바로가기 [Article Type] Letter
Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation단순 비뇨 생식기 임질 치료를 위한 게포티다신: 2상, 무작위, 용량 범위, 단일 경구 용량 평가Articles and Commentaries Published on 2018-08-152022-09-07 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 1:1 95% confidence interval adverse event adverse events Antibiotics Bacterial baseline clinical collected Culture cure demonstrated dose drug-resistant effective Efficacy and safety enrolled evaluated Gender gepotidacin gonorrhea groups highest infections inhibitor inhibitory concentration isolate isolates microbiologically Mutation Neisseria gonorrhoeae New participant Participants pharyngeal Phase 2 Phase 2 study Randomized receive rectal rectal specimens rectal swab Registration specimen stratified susceptibility Swab therapeutic option Treatment urogenital [DOI] 10.1093/cid/ciy145 PMC 바로가기 [Article Type] Articles and Commentaries