Intensity and Dynamics of Anti-SARS-CoV-2 Immune Responses after BNT162b2 mRNA Vaccination: Implications for Public Health Vaccination StrategiesArticle Published on 2022-02-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Affect age Antibody responses Autoimmune disease automated BNT162b2 BNT162b2 mRNA cell-mediated immune response cellular response Cellular responses correlation COVID-19 COVID-19 infection COVID-19 vaccination demonstrated dose Dynamics ELISA assays enrolled evaluated first dose first vaccination humoral Humoral response IgA IgA response IgA titer IgG IgG response IgG responses immunization implication individual information intensity Laboratory majority median Microparticle of BNT162b2 Participants positive antibody response positively correlated Public public health required response second vaccination significantly Strategy systemic adverse reaction T cell responses vaccinated individuals vaccination Vaccination strategies were assessed [DOI] 10.3390/vaccines10020316 PMC 바로가기 [Article Type] Article
Seroprevalence of SARS-CoV-2 among potential convalescent plasma donors and analysis of their deferral pattern: Experience from tertiary care hospital in western India잠재적 회복기 혈장 기증자 중 SARS-CoV-2의 혈청 유병률 및 연기 패턴 분석: 인도 서부의 3차 진료 병원 경험Article Published on 2022-02-012022-09-12 Journal: Transfusion clinique et biologique : journal de la [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Act age Analysis anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Antibody Response antibody stability Blood calculated Care CBC convalescent plasma Convalescent plasma donor COVID-19 COVID-19 recovered patient criteria develop Donor donors drug eligible enrolled evaluate experience Gender groups help hospital identify IgG IgG antibodies IgG antibody IgG SARS-CoV-2 antibody immunoassay India ineligible Infection lab material Microparticle MOST no significant difference persistence plasma Plasmapheresis Plasmapheresis donor deferral positive Prospective Study Protective recovered COVID-19 patient Recovered COVID-19 patients recovered patient Reinfection required SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG antibody SARS-COV-2 infection serology Seroprevalence Serum protein study period Symptom tested Till transmission of SARS-CoV-2 Treatment with COVID-19 [DOI] 10.1016/j.tracli.2021.07.004 PMC 바로가기 [Article Type] Article
Exploring Rapid and Effective Screening Methods for Anti-SARS-CoV-2 Neutralizing Antibodies in COVID-19 Convalescent Patients and Longitudinal Vaccinated PopulationsArticle Published on 2022-01-272022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Assessing BBIBP-CorV BBIBP-CorV vaccination binding antibodies binding antibody CMIA cohorts convalescent convalescent patient convalescent patients (CP) coronavirus disease correlated COVID-19 Critical declined dose ELISA enzyme-linked immunosorbent evaluate immunoassay longitudinal Microparticle MOST NAb neutralization neutralizing antibodies (NAbs) neutralizing antibody Patient performed Population protective immunity pseudovirus public health Rapid reached Research response SARS-CoV-2 SARS-COV-2 infection Screening screening test shown vaccination Vaccine vaccinee vaccinees [DOI] 10.3390/pathogens11020171 PMC 바로가기 [Article Type] Article
Circulating Microparticles in the Pathogenesis and Early Anticoagulation of Thrombosis in COVID-19 With Kidney InjuryCell and Developmental Biology Published on 2022-01-182022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] abnormality Activation Acute kidney injury affecting aggravate anticoagulant therapy anticoagulation Apoptosis binding site Blood blood cell blood circulation blood flow velocity can be used caused cells circulating clinical manifestations clinical outcomes clinical study Coagulation coagulation cascade Coagulopathy complexes consequence COVID-19 COVID-19 infection cytokine damaged cells dead Diseases early anticoagulation endothelial injury hospital hypercoagulability Immune cell impaired function IMPROVE inflammatory factors Injury kidney Kidney injury mechanism membrane Microparticle Mortality oxygen pandemic pathophysiological mechanism Patient Perspective Phosphatidylserine platform predict progression Prophylactic provide reduce rehabilitation released renal resulting risk factor thrombosis Treatment Vascular vascular endothelial cells viruses [DOI] 10.3389/fcell.2021.784505 PMC 바로가기 [Article Type] Cell and Developmental Biology
The Central Role of Extracellular Vesicles in the Mechanisms of Thrombosis in COVID-19 Patients With Cancer and Therapeutic StrategiesCell and Developmental Biology Published on 2022-01-122022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] activate aggravate amplification amplify Antithrombotic antithrombotic therapy Apoptosis benefit Blood blood cell Blood coagulation blood flow Cancer Cell clinical manifestations Coagulation coagulation cascade contribute contributing to COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines storm early stage Endothelial cell facilitate highlight Immune cell incidence maintain mechanism Microparticle microparticles microthrombi Mortality oxygen saturation pathophysiological mechanism pathway Patient Phosphatidylserine positive feedback loop proinflammatory cytokines promote resulting role SARS-CoV-2 susceptibility severe COVID-19 infections Strategy subsequent suggested the disease thrombosis thrombus formation treatment strategy tumor cell Venous thrombosis viral clearance virus [DOI] 10.3389/fcell.2021.792335 PMC 바로가기 [Article Type] Cell and Developmental Biology
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophagesACE2 발현 미립자에 의한 SARS-CoV-2 치료 효과는 폐포 대식세포의 산화된 콜레스테롤 증가 엔도솜 pH로 설명Article Published on 2022-01-042022-09-12 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] A549 addition Administered alveolar macrophage Alveolar macrophages anatomical cell-derived microparticle cholesterol cross-talk decrease Degradation Effect Efficacy emerging respiratory virus Endosomal acidification endosomal pH Endosomes explained feasibility feature highlight immune system impairing inhibit lung lysosomal lysosome Lysosomes membranes Microparticle microparticles oxidized phenotype proinflammatory Regulation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 treatment SARS-CoV-2-infected patient Side effects therapeutic therapy translocated treat Treatment viral infection [DOI] 10.1038/s41423-021-00813-6 PMC 바로가기 [Article Type] Article
Inactive SARS-CoV-2 vaccine generates high antibody responses in healthcare workers with and without prior infection비활성 SARS-CoV-2 백신은 감염 여부에 관계없이 의료 종사자에게 높은 항체 반응을 생성합니다.Article Published on 2022-01-032022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] 95% CI Abbott age Anti-spike antibody Antibody Response Antibody titers approach benefit cellular immune responses Chemiluminescent microparticle immunoassay China CMIA CoronaVac COVID-19 Dilution dose effective faculty female first dose generate group HCW HCWs healthcare worker Healthcare workers humoral Humoral and cellular immune responses Humoral immunity hypertension IgG IgG level IgG levels immune responses immunoassay inactive Infection İstanbul life male material Microparticle monitoring neutralization test Participants Patient plaque reduction neutralization Plaque reduction neutralization test PRNT required SARS-CoV-2 vaccine second dose significantly higher significantly lower Sinovac Life Sciences Spread study group the anti-spike/RBD antibody. Turkey USA vaccination Vaccine variants was used were measured [DOI] 10.1016/j.vaccine.2021.11.051 PMC 바로가기 [Article Type] Article
Affinity of anti-spike antibodies in SARS-CoV-2 patient plasma and its effect on COVID-19 antibody assaysSARS-CoV-2 환자 혈장에서 스파이크 방지 항체의 친화성과 COVID-19 항체 분석에 미치는 영향Article Published on 2022-01-012022-09-12 Journal: EBioMedicine [Category] SARS, 진단, [키워드] Abbott Laboratories Abbott Laboratory Affect affinity Affinity maturation anti-SARS-CoV-2 Anti-spike anti-spike antibody Anti-viral anti-viral antibody antibodies antibody antibody affinity apparent affinity binding antibody Blood complexes Concentration convalescent COVID-19 antibody determine diagnostics Direct faster fluorescence microscopy funding source HDIA higher affinity Human plasma immunoassay immunoassays individuals Interpretation Microparticle parameter Patient plasma Protein provided quantification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination serum turn vaccinated individuals vaccination were used [DOI] 10.1016/j.ebiom.2021.103796 PMC 바로가기 [Article Type] Article
Immunogenicity and safety of mRNA COVID-19 vaccines in people with multiple sclerosis treated with different disease-modifying therapies다양한 질병 조절 요법으로 치료받는 다발성 경화증 환자에서 mRNA COVID-19 백신의 면역원성과 안전성Article Published on 2022-01-012022-09-11 Journal: Neurotherapeutics : the journal of the American So [Category] SARS, 진단, 치료기술, [키워드] Alemtuzumab Cladribine correlation COVID-19 COVID-19 vaccination detect develop Disease-modifying therapies drugs evaluated fatigue fingolimod Hospitalization humoral humoral immune response Humoral response IgG immune response immunoassay immunogenicity injection injection site Microparticle MONITOR mRNA COVID-19 vaccine mRNA COVID-19 vaccines Multiple multiple sclerosis Natalizumab Ocrelizumab Pain Patient patients treated positively correlated reduce reported Safe SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleoprotein second dose Side effect significantly lower therapy treated Treatment vaccination was tested [DOI] 10.1007/s13311-021-01165-9 PMC 바로가기 [Article Type] Article
Persistence of Antibodies Against Spike Glycoprotein of SARS-CoV-2 in Healthcare Workers Post Double Dose of BBV-152 and AZD1222 VaccinesMedicine Published on 2021-12-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Against age anti-S IgG antibody Antibody titer antibody waning AZD1222 BBV-152 and AZD1222 Blood clinical implication collected Comorbidities Complete conducted coronavirus decrease detect dose Follow-up follow-up study Gender groups HCW HCWs healthcare healthcare worker highlight IgG IgG antibody immunoassay Immunoglobulin Infection investigated longitudinal cohort study median Microparticle participant Participants persistence platform postvaccination produced recipient recipients Reinfection required Research SARS-CoV-2 SARS-CoV-2 antibody serum sample significantly higher spike spike glycoprotein statistically significant difference tested threshold vaccination Vaccine Vaccines were recorded worker [DOI] 10.3389/fmed.2021.778129 PMC 바로가기 [Article Type] Medicine