mouse-adapted SARS-CoV-2

[키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Adaptive immunity addition analyzed antibody antiviral efficacy Arm backbone candidate caused CD4 CD8 Coronavirus-2 country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines death deaths effective effective immunity Effective vaccines effort experiments expressing full-length S protein functional immune response genomic position gravity hamster identify IgG antibody immune immune responses Immunity immunogenic immunopathology in vivo induce insertion killing measles measles vaccine platform measles virus mice modulated mouse mouse-adapted SARS-CoV-2 multifunctional Neutralizing Patient Protective public health respiratory response S protein S protein expression Safe SARS-CoV-2 SARS-CoV-2 spike glycoprotein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Significance significantly lower situation solution spike glycoprotein Spread Support T cell T cell response T cell responses Th1 immune bias the SARS-CoV-2 Threats vaccination Vaccine vaccine candidate variant virus virus load yielding
[DOI] 10.1073/pnas.2014468117 PMC 바로가기 [Article Type] 530