Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model코로나바이러스 질환 2019(COVID-19) mRNA 백신의 정맥 주사가 마우스 모델에서 급성 심근염을 유발할 수 있음Article Published on 2022-06-102022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome antigen expression Apoptosis Ballooning degeneration Blood Can cardiac Cardiac pathology change changes clinical manifestations coronavirus coronavirus disease COVID-19 COVID-19 mRNA vaccine different time point dose Evidence evidenced hepatocyte histological change histopathological IL-6 immunization immunostaining in vivo induce infiltrating immune cell inflammatory cell infiltration injection interferon intracardiac intramuscular intravenous Intravenous injection Messenger RNA mice Model mouse mouse model mRNA mRNA expression mRNA vaccine myocytes Myopericarditis Necrosis other organ provided reduce reported risk SARS-CoV-2 serum Serum level significantly significantly higher skeletal tissue Vaccine vaccine injection Vaccines vascular endothelial cells visceral weight loss Withdrawal [DOI] 10.1093/cid/ciab707 PMC 바로가기 [Article Type] Article
ACE2 expression in saliva of patients with COVID-19 and its association with Candida albicans and Aggregatibacter actinomycetemcomitansArticle Published on 2022-05-232022-11-16 Journal: F1000Research [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 expression ACE2 mRNA Actin Aggregatibacter actinomycetemcomitans ALS3 Analysis angiotensin-converting enzyme 2 association Bacteria C. albican Candida Candida albican Candida albicans collected contribute control group controls correlation COVID-19 COVID-19 severity determine diabete evaluated expression Fusobacterium Fusobacterium nucleatum Genes groups healthy hospitalized patient hyphal Indonesia investigated involved mRNA expression no significant difference oral microbiota participant Patient patients patients with COVID-19 patients with diabete PCR-confirmed COVID-19 performed Prognosis proportion Protein protein 3 qPCR quantitative PCR Saliva SARS-COV-2 infection selected significantly higher subject susceptibility Swab swab sample the patient tongue Transcription Veillonella parvula. [DOI] 10.12688/f1000research.111965.2 PMC 바로가기
Effects of Drugs Formerly Suggested for COVID-19 Repurposing on Pannexin1 Channels이전에 COVID-19 용도 변경을 위해 제안된 약물이 Pannexin1 채널에 미치는 영향Article Published on 2022-05-182022-09-11 Journal: International Journal of Molecular Sciences [Category] 신약개발, 유전자 메커니즘, [키워드] Alter Analysis Anti-inflammatory Anti-inflammatory drugs Antiviral antiviral and anti-inflammatory drugs Azithromycin candidate Chain Reaction channel Chloroquine clinical trial clinical trials Combination COVID-19 COVID-19 patients Dexamethasone Diseases drug drug candidate drug target Effect effort extracellular ATP Favipiravir functional Hydroxychloroquine immune response Immunoblot analysis Inflammation inhibit inhibitor Lopinavir mechanism mRNA expression mRNA levels outcome pandemic pannexin1. Pathogenesis pathogenesis of COVID-19 polymerase chain polymerase chain reaction Protein Quantitative Remdesivir repurposing ribavirin Ritonavir selected tested Treatment viral infections were used without affecting [DOI] 10.3390/ijms23105664 PMC 바로가기 [Article Type] Article
Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19SARS-CoV-2에 감염된 Caco-2 장 세포에서 CDH1/E-Cadherin 유전자 발현 및 가용성 형태의 E-Cadherin 방출 제어: COVID-19의 장 형태에 대한 생리병리학적 결과Article Published on 2022-05-042022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] 24 hour 24 hours 48 hour 48 hours ACE2 ACE2 mRNA Affect AT1 Caco-2 Caco-2 cell Caco-2 cells cadherin CDH1 Cell cell line cells Co-receptor connexin consequence contributing to Control COVID-19 Culture culture supernatant diarrhoea diarrhoea) digestive tract Disruption dissemination down-regulated dysregulation E-cadherin ENCODE epithelial exposure to expresse expression form Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract HCoV HCoV-OC43 HLA class I human ACE2 illnesses in viral induce infected with SARS-CoV-2 Infection intestinal Intestinal barrier intestinal cells intestinal tissue intranasal involved JAMA junctions leads membrane mRNA mRNA expression OC43 occludin pandemic Patient Physiopathological Post-infection Protein receptor receptor ACE2 Release remained reported respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection significant increase significantly lower Symptom the disease these symptoms TMPRSS2 Transcription transgenic mice Trigger Viral viral entry virus [DOI] 10.3389/fcimb.2022.798767 PMC 바로가기 [Article Type] Article
In Vitro SARS-CoV-2 Infection of Microvascular Endothelial Cells: Effect on Pro-Inflammatory Cytokine and Chemokine Release미세혈관 내피 세포의 시험관 내 SARS-CoV-2 감염: 염증성 사이토카인 및 케모카인 방출에 대한 영향Article Published on 2022-04-062022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 receptor Activation Analysis chemokine contribute coronavirus disease Coronavirus disease 2019 cytokine release Cytokines cytoplasm days post-infection dysfunction Effect electron ELISA endothelial Endothelial cell evaluated expressed expression Human Human Microvascular Endothelial Cells (HMEC-1) IFN-α IL-6 IL-6 level IL-6 levels IL-8 in vitro Inflammatory mediators mRNA mRNA expression pandemic pro-inflammatory cytokine pro-inflammatory cytokines pro-inflammatory mediators Release RT-PCR SARS-CoV-2 SARS-COV-2 infection significantly higher significantly lower supernatant supernatants susceptible TEM These data thrombotic Thrombotic events tissue Tissue Factor TNF-α transmission electron microscopy uninfected viral amplification Viral load virion virions western blot Western blot analysis [DOI] 10.3390/ijms23074063 PMC 바로가기 [Article Type] Article
CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA- and RBP-dependent manner Research Published on 2022-03-252022-10-05 Journal: Cell Death & Disease [Category] 바이오마커, [키워드] activated Analysis applied backbone Beta Cancer cancer progression cancers cells Circular Diagnosis ENhance expression expression pattern facilitated feasible immunoprecipitation in vitro in vivo INHBA inhibin investigated loss-of-function malignancy mechanism mRNA expression mRNA stability oncogenic pathway performed poor prognosis progression promote pull-down Regulatory reporter Research RNA screened significantly increased stability TGF-β Transcriptome Treatment [DOI] 10.1038/s41419-022-04720-0 [Article Type] Research
Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19 Research Published on 2022-03-212022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] acute respiratory syndrome age alteration anti-SARS-CoV-2 blockade contributed coronavirus Coronavirus disease 2019 COVID-19 dendritic cell effective Efficacy eicosanoid elevated expression Human immune pressure indicate Intervention Isolation lethal infection mice mononuclear cells mouse-adapted SARS-CoV-2 mRNA expression murine outcome pathway Peripheral blood PGD2 Phospholipase A2 PLA2G2D populations prostaglandin D2 PROTECT PTGDR receptor required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant severe COVID-19 severe disease severity the spike protein therapeutic drug therapeutic interventions Therapies Treatment Vaccine variant virulent virus [DOI] 10.1038/s41586-022-04630-3 [Article Type] Research
Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19IL17의 유전적 연관성과 코로나19에 대한 타액 내 ABO 혈액형 항원의 중요성Article Published on 2022-03-092022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] ABO Activation Analysis Antigen association Blood Group carried caused conducted COVID-19 COVID-19 patient determine Factor FOXP4 FOXP4-AS1 FUT2 General population Genetic genetic association genetic factors genetics genome-wide association Genome-wide association study Genomic analysis Genotype GWAS identify IFNAR2 IL17 IL17A IL17F individual infection with SARS-CoV-2 innate immune response International involved Japan Japanese Meta-analysis mRNA expression nine outbreak Patient presenting replicated reported Respiratory failure risk allele Risk factors Saliva SARS-COV-2 infection SARS-CoV-2 virus severe COVID-19 severity severity of COVID-19 significantly significantly lower SNP virus worldwide pandemic [DOI] 10.1038/s41598-022-07856-3 PMC 바로가기 [Article Type] Article
In vivo antiviral effect of plant essential oils against avian infectious bronchitis virusResearch Published on 2022-03-072022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] Anti-inflammatory antibody Antibody titer antiviral drug Antiviral effect bronchitis Clinical signs Concentration cytokine cytokine levels dose effective evaluated glycerol GML group groups High dose highest IBV IBV infection IFN-γ IL-4 IL-6 level immune immune function immune response in vivo infection rate Infectious Bronchitis Virus inhibiting inhibition low dose mRNA expression Mutation organ Plant essential oils positive Protective reduced Result significantly significantly higher significantly lower supplementary material Symptom Vaccine viral loads virus virus multiplication [DOI] 10.1186/s12917-022-03183-x PMC 바로가기 [Article Type] Research
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2COVID-19 수용체 및 악성 암: SARS-CoV-2에 대한 감수성과 CTSL 발현의 연관성Article Published on 2022-03-062022-09-11 Journal: International Journal of Biological Sciences [Category] SARS, 변종, [키워드] A549 ACE2 ACE2 mRNA Analysis analyzed Cancer cancer cell line cancer cell lines cancer patient Cancer patients cancer progression cancer tissue cancers conserved cordycepin Cordycepin (CD) correlated correlation COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 severity COVID-19 treatment Critical CTSL cysteine disease domain dose ENCODE evaluate expressed expression furin glioma highest Human IHC immunohistochemistry inhibit inhibited isoform lung lung cancer lung tissue Lungs lysosomal malignant Malignant cancers modulating MONITOR mRNA expression mutant Mutation mutation rate N6, N6-dimethyladenosine (m62A) other proteases outcome Pathogenesis Patient PC3 performed predict prevalent Proteases Protein proteinase receptor regulate Regulation SARS-CoV-2 SARS-CoV-2 entry significantly survival susceptibility The CTSL gene. therapeutic potential These data tissue tissues TMPRSS2 Treatment Tumor tumor progression western blot [DOI] 10.7150/ijbs.70172 PMC 바로가기 [Article Type] Article