Screening out anti-inflammatory or anti-viral targets in Xuanfei Baidu Tang through a new technique of reverse finding target리버스 찾기 목표의 새로운 기술을 통해 Xuanfei Baidu Tang에서 항 염증 또는 항 바이러스 표적을 선별Article Published on 2021-11-012022-08-31 Journal: Bioorganic chemistry [Category] SARS, 신약개발, 치료제, [키워드] Anti-inflammatory Anti-viral Baidu Chinese Compound computer-aided drug design COVID-19 database Discovery Studio drug Effect effective help herbal medicine identify multi PDB predict Protein Data Bank protein p53 Reverse finding target screened Screening searched synergistic target targets The traditional Chinese herbal medicine. TP53 Traditional Treatment treatment of COVID-19 Tumor [DOI] 10.1016/j.bioorg.2021.105274 PMC 바로가기 [Article Type] Article
Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-LSARS-CoV-2 주요 프로테아제(Mpro/3CLpro) 및 인간 카텝신-L에 대한 MG-132의 이중 억제 구조 및 생화학적 분석Article Published on 2021-10-292022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료제, [키워드] active site Antiviral strategies binding biochemical catalytic cathepsin Cathepsin-L conditions covalent binding covalent bond COVID-19 pandemic Cys145 cysteine docking drug design dual target inhibitor effective drugs Evidence feature group highlighting Human in silico inhibit inhibited inhibition MG-132 MPro Mpro/3CLPro multi peptidomimetics Perspective protease reducing Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease similarity Structure therapy X-ray diffraction [DOI] 10.3390/ijms222111779 PMC 바로가기 [Article Type] Article
Anaesthetic challenges in a child with perforated appendicitis and COVID-19 Co-Infection: A case reportCase Report Published on 2021-10-122022-10-28 Journal: Annals of Medicine and Surgery [Category] COVID-19, [키워드] Perforated appendicitis Affect appendicectomy Appendicitis Care Case report caused challenge Child children children with COVID-19 Co-infection coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic cross Cross-infection defend detrimental effect equipment Good handling HCW healthcare worker hospital infected with COVID-19 Infection initial management measure multi operating theatre pandemic parent Patient patients patients with COVID-19 Personal protective equipment positive PPE Prevent problem Protective receive resource risk routine care Safe Spread spread of COVID-19 surgical the patient upper respiratory tract wearing with COVID-19 [DOI] 10.1016/j.amsu.2021.102931 PMC 바로가기 [Article Type] Case Report
Bacterial and fungal ventilator associated pneumonia in critically ill COVID-19 patients during the second wave2차 유행 동안 중환자 COVID-19 환자의 박테리아 및 곰팡이 인공 호흡기 관련 폐렴Article Published on 2021-10-012022-09-11 Journal: Journal of infection and public health [Category] SARS, 치료기술, [키워드] 95% CI 95% confidence interval Acinetobacter admitted to ICU antimicrobial antimicrobial resistance antimicrobial susceptibility Aspergillus Bacteria Bacterial Bacterial infections Candida caused Chest collected coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient Critical Critically ill critically ill COVID-19 patients Culture diabetes Diabetes Mellitus diagnosed disease element followed by fungal fungi Hypothyroidism ICUs identify intensive care unit intensive care units isolate isolates Klebsiella pneumoniae MDR mechanical ventilation Mucor multi outcomes pandemic Patient PDR Pneumonia pneumoniae positive respiratory Respiratory samples risk factor Risk factors SARS-CoV2 second wave specimen specimens subsequent susceptibility Tocilizumab Treatment VAP ventilator Ventilator associated pneumonia [DOI] 10.1016/j.jiph.2021.08.003 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 genome and whole transcriptome sequencing in frontal cortex of COVID-19 patientsCOVID-19 환자의 전두엽 피질에서 SARS-CoV-2 게놈 및 전체 전사체 시퀀싱 검출Article Published on 2021-10-012022-09-11 Journal: Brain, behavior, and immunity [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] affected Analysis Brain categories category Control controls COVID-19 COVID-19 patient COVID-19 patients Defense demonstrated Deprivation detection died downregulation dysfunction examined expressed Frontal Frontal cortex Gene Expression hemoglobin hydrogen hydrogen peroxide hypoxia infect Infection inhibit investigated lncRNA Manifestations molecular mRNA mRNAs multi nervous neurological organ Patient Protein qRT-PCR quantity remains uncertain replicate RNA-seq analysis SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection Structure System tissue transcriptional Transcriptome transcriptome sequencing transcriptomic analysis transcriptomic profile Viral RNA [DOI] 10.1016/j.bbi.2021.05.012 PMC 바로가기 [Article Type] Article
Rapid Acquisition of High-Quality SARS-CoV-2 Genome via Amplicon-Oxford Nanopore SequencingAmplicon-Oxford 나노포어 시퀀싱을 통한 고품질 SARS-CoV-2 게놈의 신속한 획득Article Published on 2021-10-012022-09-11 Journal: Virologica Sinica [Category] SARS, 치료기술, [키워드] acquisition Amplicon amplification Analysis approach complexity comprehensive evaluation conducted correlated COVID-19 pandemic COVID-19 patient Ct value Ct values detect effective error rate evaluated experiment Genetic Genome Genome sequencing genomic Illumina IMPROVE indicated initial less multi Mutation nanopore sequencing nucleic acid Oxford pathogen identification PCR platform Rapid resource SARS-CoV-2 SARS-CoV-2 genome Sequencing shown specimen Stage throat swab transcript Variation Viral load virus were assessed while yielding [DOI] 10.1007/s12250-021-00378-8 PMC 바로가기 [Article Type] Article
Modelling and optimal control of multi strain epidemics, with application to COVID-19Research Article Published on 2021-09-162022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Brazil COVID-19 COVID-19 epidemic COVID-19 pandemic England Epidemic Epidemics Immunity include infection levels measure multi rapid increase Reinfection viral disease viral strain viral strains waning immunity [DOI] 10.1371/journal.pone.0257512 PMC 바로가기 [Article Type] Research Article
Operationalizing Cooperative Research for Infectious Disease Surveillance: Lessons Learned and Ways Forward감염병 감시를 위한 협력 연구 운영: 교훈과 앞으로의 길Public Health Published on 2021-09-102022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 치료기술, [키워드] approach capacity building Central Asia commitment Cooperative cooperative research country COVID-19 COVID-19 pandemic develop diagnostics disease outbreaks effective ENhance Epidemic expectation Forward funds global health security health systems highlight include Infectious disease Infectious disease surveillance Laboratory lesson mitigate multi National outbreak Outbreaks outcome pandemic pathogen Pathogens pivot predict preventative measure preventative measures reducing required Research resolved Surveillance threat Treatment while [DOI] 10.3389/fpubh.2021.659695 PMC 바로가기 [Article Type] Public Health
Community engagement in the prevention and control of COVID-19: Insights from VietnamCovid-19의 예방 및 통제에 대한 지역 사회 참여 : 베트남의 통찰력Research Article Published on 2021-09-082022-09-10 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] activity analyzed approach approval building carried Community Compliance contribute Control COVID-19 cross-sectional Data collection Decision making determinant Early detection effective effective response Engagement FIVE foster Government groups Health health authorities highlight highlighting Hospitalization Households IMPROVE individual Infection infection control insight institutional review board Isolation knowledge Local lockdowns migrant workers mobilization multi organization outcomes prevention Prevention and control public health qualitative data quarantine replicated resource resources Result risk selected sense sensitization social distancing Social Security steering committee Structure Study design supervision Support thematic analysis Travel Trust university vice was collected was used with COVID-19 zone [DOI] 10.1371/journal.pone.0254432 PMC 바로가기 [Article Type] Research Article
Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvementCOVID-19와 자가면역의 해결: 그럴듯한 표적의 식별은 다기관 관련을 시사합니다Article Published on 2021-09-012022-09-12 Journal: Molecular immunology [Category] MERS, SARS, 진단, [키워드] acting autoantibody autoantigen autoimmune condition autoimmune conditions Autoimmunity B cell epitope conserved COVID-19 COVID-19 patient demonstrated displaying distribution exacerbated explain homologous human protein Hypothesis identification Inflammation management manifestation mechanism molecular molecular mimicry multi Multi-organ damage Occurrence organ Region reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 proteins subsequent symptoms of COVID-19 target tissue triggering widespread [DOI] 10.1016/j.molimm.2021.06.021 PMC 바로가기 [Article Type] Article