N-glycosylation – Page 3 – Communicable Diseases Research

Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2

Research Article

Published on 2021-09-082022-10-30
Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS,

N-Glycosylation of the SARS-CoV-2 Receptor Binding Domain Is Important for Functional Expression in Plants

Plant Science

Published on 2021-06-152022-10-31
Journal: Frontiers in Plant Science [Category] COVID-19,

Comprehensive characterization of N- and O- glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2

SARS-CoV-2 인간 수용체 안지오텐신 전환 효소 2의 N- 및 O- 글리코실화에 대한 포괄적인 특성화

Article

Published on 2021-05-032022-09-11
Journal: Glycobiology [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 ACE2 glycosylation ACE2 site mapping acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition age Analysis angiotensin angiotensin converting enzyme assist bind binding bioinformatics caused characterized Complication Comprehensive condition conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19 receptor enzyme epitope Epitopes expressed feature GlcNAc glycopeptide glycosylation glycosylation site hACE2 hACE2 N-glycosylation. hACE2 receptor HEK293 cells human angiotensin converting enzyme 2 in viral Interaction Interpretation involved membrane fusion mode modeling N-glycosylation N-glycosylation site O-glycosylation site pandemic pattern Prevent Protein receptor Replication S protein SARS-CoV-2 SARS-CoV-2 receptor Seven severe acute respiratory syndrome Coronavirus Sex sialic acid Therapeutic strategies trimeric spike understanding viral entry
[DOI] 10.1093/glycob/cwaa101 PMC 바로가기 [Article Type] Article

High-level expression of the monomeric SARS-CoV-2 S protein RBD 320-537 in stably transfected CHO cells by the EEF1A1 -based plasmid vector

EEF1A1 기반 플라스미드 벡터에 의한 안정적으로 형질감염된 CHO 세포에서 단량체 SARS-CoV-2 S 단백질 RBD 320-537의 고수준 발현

Research Article

Published on 2021-02-022022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19,

[키워드] Accuracy acute respiratory syndrome Alpha amplification analyzed Antigen antigenic antigenic determinants C-terminal Cell culture cell line Chinese hamster CHO cell condition coronavirus coronavirus 2 Coronaviruses described determinant domain EEF1A1 elongation factor exceeded except for expression gel gel filtration Genetic Genome glycans glycosylation Host immune response inducer mammalian mass spectrometry methotrexate monomeric N-glycosylation peptide performed Plasmid PNGase F polyacrylamide polyacrylamide gel produced Protein purification RBD RBD protein recombinant Recombinant SARS-CoV-2 RBD reducing regulatory sequence regulatory sequences respiratory S protein S proteins SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S protein selected serological serological test Serological tests severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signal peptide subunit Subunit vaccine the S protein transfected cells translation unique Vaccine variant Viral viral envelope viral signal was obtained
[DOI] 10.1371/journal.pone.0242890 PMC 바로가기 [Article Type] Research Article

Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy

SARS-CoV-2의 게놈 역학은 이탈리아 롬바르디아에서 여러 계통과 SARS-CoV-2 감염의 조기 확산을 보여줍니다

Observational Study

Published on 2021-01-192022-09-10
Journal: Nature Communications [Category] MERS, 변종, 유전자 메커니즘, 임상, 치료기술,

CoV3D: a database of high resolution coronavirus protein structures

AcademicSubjects/SCI00010

Published on 2021-01-082022-10-31
Journal: Nucleic Acids Research [Category] COVID-19,

The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles

Research Article

Published on 2020-12-032022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome biochemical C-terminal Cell composed coronavirus COVID-19 COVID-19 pandemic Critical cytoplasmic tail DMEM, Dulbecco’s modified minimal essential medium E, Envelope Endoplasmic reticulum ERGIC ERGIC, endoplasmic reticulum (ER)–Golgi intermediate compartment glycoprotein Golgi highlight IBV, infectious bronchitis virus IF, immunofluorescence induce infected cell Infectious disease Interaction Like M protein M, membrane maturation membrane membrane protein MERS-CoV, Middle East Respiratory Virus modulate modulating motif N-glycosylation N, nucleoprotein other coronaviruses Particle Particles Prevent promote Protein Proteins purified regulate Regulation required S protein S, spike SARS-CoV SARS-CoV-2 SARS-CoV-2 envelope SARS-CoV-2 viral particles SARS-CoV-2-infected cells SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 secretion secretory pathway structural protein syncytia formation the spike protein transfected cells Viral particles Viral protein virus assembly Virus-like particle VLPs, Virus-like particles vRNP, viral ribonucleoprotein β-coronavirus
[DOI] 10.1074/jbc.RA120.016175 PMC 바로가기 [Article Type] Research Article

The biogenesis of SARS-CoV-2 spike glycoprotein: multiple targets for host-directed antiviral therapy

Review

Published on 2020-11-282023-07-01
Journal: Biochemical and Biophysical Research Communication [Category] SARS,

[키워드] Antiviral coronavirus COVID-19 ERp57 furin N-glycosylation
[DOI] 10.1016/j.bbrc.2020.10.080 PMC 바로가기 [Article Type] Review

Development of an antibody-dependent cellular cytotoxicity reporter assay for measuring anti-Middle East Respiratory Syndrome antibody bioactivity

Article

Published on 2020-10-062022-10-29
Journal: Scientific Reports [Category] Coronavirus, MERS,

[키워드] ADCC ADCC activity addition antibodies antibody antibody-dependent cellular cytotoxicity antiviral antibody Antiviral effect Bioactivity Biological techniques cause Cell condition coronavirus demonstrated development Drug discovery East effector cells expressing high accuracy in vivo include infections Live virus MERS MERS-CoV MERS-S Middle East Modification N-glycosylation neutralization activity Neutralization assay NFAT pathogen Precision provide pseudovirus recent reporter reporter gene assay required respiratory robust target cell the spike protein therapeutic Treatment virulent virus clearance
[DOI] 10.1038/s41598-020-73960-x PMC 바로가기 [Article Type] Article

Analysis of HBsAg mutations in the 25 years after the implementation of the hepatitis B vaccination plan in China

Article

Published on 2020-10-012023-06-11
Journal: Virus Genes [Category] B형 간염,

[키워드] Hepatitis B virus mutation rate N-glycosylation stop codon Vaccine
[DOI] 10.1007/s11262-020-01773-1