N501Y – Page 3 – Communicable Diseases Research

Evolving strategy for an evolving virus: Development of real-time PCR assays for detecting all SARS-CoV-2 variants of concern

진화하는 바이러스에 대한 진화하는 전략: 우려되는 모든 SARS-CoV-2 변이체를 검출하기 위한 실시간 PCR 분석법 개발

Article

Published on 2022-09-012022-09-11
Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제,

Mutational dynamics across VOCs in International travellers and Community transmission underscores importance of Spike-ACE2 interaction

국제 여행자의 VOC와 지역 사회 전파에 걸친 돌연변이 역학은 Spike-ACE2 상호 작용의 중요성을 강조합니다.

Article

Published on 2022-09-012022-09-11
Journal: Microbiological research [Category] COVID19(2023년), SARS, 변종,

[키워드] A570D Alpha analysed B.1.617.2 binding binding affinity change Community community transmission comparable COVID-19 case COVID-19 pandemic D1118H D950N Delta demonstrated different time point different time points disequilibrium early phase emergence Evolution functional G142D Genomic surveillance India Interaction International investigated L452R Lineage linkage Linkage disequilibrium Mutation mutation analysis mutations N501Y notable omicron ORF1 ORF1ab overlap predict raised S982A SARS-CoV-2 selective spike spike mutations spike-ACE2 Spread Structural analysis Transmissibility Transmission transmission pattern unique vaccination variants variants of concern VoC VOCs
[DOI] 10.1016/j.micres.2022.127099 PMC 바로가기 [Article Type] Article

Rapid and qualitative identification of SARS-CoV-2 mutations associated with variants of concern using a multiplex RT-PCR assay coupled with melting analysis

Article

Published on 2022-09-012022-11-16
Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술,

Omicron Binding Mode: Contact Analysis and Dynamics of the Omicron Receptor-Binding Domain in Complex with ACE2

오미크론 결합 모드: ACE2와 복합된 오미크론 수용체 결합 도메인의 접촉 분석 및 역학

Article

Published on 2022-08-222022-09-11
Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies B.1.1.529 binding complex complexes Contact COVID-19 Department distribution domain Dynamics edge Effect electrostatic form H-bond host receptor human ACE2 IMPROVE Interaction Lineage molecular molecular dynamics Mutation mutations N501Y omicron Omicron variant Open Science Framework Protein Proteins Receptor-binding domain resistance S-RBD Salt Bridge salt bridges SARS-CoV-2 virus spike Spike protein Spike proteins Stanford the receptor-binding domain the SARS-CoV-2 virus the Spike the WHO unique variant VoC
[DOI] 10.1021/acs.jcim.2c00397 PMC 바로가기 [Article Type] Article

In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols’ Potential for Inhibition of SARS-CoV-2 Internalization

Alchemilla viridiflora Rothm-Polyphenols의 SARS-CoV-2 내재화 억제 가능성에 대한 실리코 및 체외 연구

Article

Published on 2022-08-142022-09-11
Journal: Molecules [Category] SARS, 변종,

[키워드] ACE2 Alchemilla viridiflora Rothm. angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents binding binding energy binding interaction Compound computational studies Computational study Contact COVID-19 COVID-19 pandemic dose doses E484K effective Effectiveness exhibited flavonoid G476S glycoprotein Health higher affinity highest in silico in vitro inhibited inhibition internalization investigated K417N methanol molecular docking studies Molecular docking study Mutation N439K N501Y neuropilin Neuropilin-1 NRP1 outbreak plants polyphenols Potential Prevent quercetin receptor receptors resulting SARS-CoV-2 SARS-CoV-2 strain selected significantly spike glycoprotein tested V483A virus virus infection Virus spike wild strain
[DOI] 10.3390/molecules27165174 PMC 바로가기 [Article Type] Article

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

인간화된 나노바디 파지 디스플레이 라이브러리는 SARS CoV-2 스파이크의 강력한 결합제를 생성합니다

Article

Published on 2022-08-102022-09-11
Journal: PLoS ONE [Category] SARS, 변종, 진단,

Genomic surveillance, evolution and global transmission of SARS-CoV-2 during 2019-2022

2019-2022년 동안 SARS-CoV-2의 게놈 감시, 진화 및 전 세계 전파

Article

Published on 2022-08-012022-09-11
Journal: PLoS ONE [Category] SARS, 변종, 유전자 메커니즘,

A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera

VFLIP-X 스파이크를 생성하는 원형 mRNA 백신 프로토타입은 마우스 혈청에 의한 SARS-CoV-2 변이체의 광범위한 중화를 제공합니다

Article

Published on 2022-08-012022-09-11
Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] addition Amino acid amino acid sequence amino acids Antibody titers B.1.1.529 B.1.617.2 balance BNT162b2 boost cellular immune responses cleavage site COVID-19 vaccine Critical D614G detectable Disulfide disulfide bond E484K Evolution of SARS-CoV-2 FIVE flexible glycosylation greater humoral Humoral and cellular immune responses immune responses immunization immunized induce K417N L452R linear linker mice mRNA mRNA vaccine mRNA vaccines mRNA-1273 N501Y neutralization Neutralizing activity Neutralizing antibody response Neutralizing antibody titer neutralizing antibody titers offer pre-fusion producing proline proline substitutions prolines reduced response S-2P SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sequence sera shown spike Spike protein spike trimer stability suggested T478K the spike protein transcript trimer trimeric Vaccine Vaccines variant variants variants of concern variants of interest VFLIP virus VOCs VOIs wildtype
[DOI] 10.1016/j.antiviral.2022.105370 PMC 바로가기 [Article Type] Article

Validation and advantages of using novel RT-qPCR melting curve analysis assays for the identification of SARS-CoV-2 variants

SARS-CoV-2 변이체 식별을 위한 새로운 RT-qPCR 용융 곡선 분석 분석 사용의 검증 및 이점

Article

Published on 2022-07-292022-09-11
Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

All-Atom Simulations of Human ACE2-Spike Protein RBD Complexes for SARS-CoV-2 and Some of its Variants: Nature of Interactions and Free Energy Diagrams for Dissociation of the Protein Complexes

SARS-CoV-2 및 일부 변이체에 대한 인간 ACE2-스파이크 단백질 RBD 복합체의 전체 원자 시뮬레이션: 단백질 복합체의 해리를 위한 상호작용 및 자유 에너지 다이어그램의 특성

Article

Published on 2022-07-282022-09-11
Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종,