Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D-mediated pyroptosisArticle Published on 2022-11-012023-06-24 Journal: Drug development research [Category] 신종인플루엔자, [키워드] Anti-inflammatory berberine gasdermin D influenza viral pneumonia NLRP3 inflammasome pyroptosis [DOI] 10.1002/ddr.21995
Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implicationsReview Published on 2022-11-012023-07-10 Journal: EBioMedicine [Category] COVID19(2023년), [키워드] Anakinra C-reactive protein canakinumab Colchicine COVID-19 IL-18 IL-1β NLRP3 inflammasome SARS-CoV-2 [DOI] 10.1016/j.ebiom.2022.104299 PMC 바로가기 [Article Type] Review
Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infectionArticle Published on 2022-09-162022-11-16 Journal: Science Advances [Category] SARS, 신약개발, [키워드] acute respiratory syndrome AIM2 Asymptomatic COVID-19 autophagy coronavirus COVID-19 develop disease FDA-approved drug human monocyte identification immunomodulatory drug immunomodulatory function impair implicated in vitro in vivo independent induce Inflammasome inflammasome activation inflammasomes inflammatory process information inhibit inhibited inhibitors Mild NIC NLRP3 NLRP3 inflammasome Patient patients with COVID-19 PBMC performed provide SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication treat Treatment [DOI] 10.1126/sciadv.abo5400 PMC 바로가기
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, BrazilArticle Published on 2022-09-052022-11-16 Journal: BioMed Research International [Category] SARS, 변종, 유전자 메커니즘, [키워드] activated allele association Asymptomatic Brazil CARD8 center clinical clinical evolution Clinical management clinical manifestations contributing to COVID-19 COVID-19 severity death disease disease severity Factors Genetic Genetic variant Genotype group Haplotype Host host cells Inflammasome Inpatient investigated knowledge logistic regression models mechanism moderate NLRP3 NLRP3 inflammasome outcomes Patient performed polymorphism Polymorphisms profile protection Real-time PCR recruited Rio de Janeiro risk risk factor SARS-COV-2 infection SARS-CoV-2-infected individual scale severe symptom severity Significant single-nucleotide SNP SNPs Symptom the WHO two group two groups variants virus was determined WHO with mild disease [DOI] 10.1155/2022/9082455 PMC 바로가기
Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19Review article Published on 2022-08-012022-10-05 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 임상, 치료제, [키워드] activated acute respiratory syndrome anti-inflammatory drug antiviral drugs autophagy Autophagy regulation caused coronavirus Coronavirus disease 2019 COVID-19 Cytokine storm early stage Evidence indicate Infection Infectious disease Inflammasome inhibiting inhibitor involved late stage Lung inflammation NLRP3 NLRP3 inflammasome protein 3 provide Regulation replication of SARS-CoV-2 SARS-CoV-2 Stage targeting the cytokine storm therapeutic potential therapy [DOI] 10.1016/j.clim.2022.109093 [Article Type] Review article
Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation바이러스 감염, 세포 사멸 및 염증에서 SARS-CoV-2 뉴클레오캡시드 단백질의 신호 전달 메커니즘Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus assembly caused cell cycle cell cycle arrest cell death complex complexes coronavirus COVID-19 Critical Cytokine storms Cytokines ENhance expression facilitate genomic RNA global public health GSDMD IFN-β in viral induce Infection Inflammation inhibit innate immune system life cycle mechanism N protein NF-κB NF-κB signaling NLRP3 NLRP3 inflammasome pathway Proinflammatory cytokine proinflammatory cytokines promote Protein pyroptosis Replication resulting RNA RNAi RNAi pathway SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid severe acute respiratory syndrome Coronavirus Signaling Smad3 stress granule stress granules survival Transcription undergo viral genome viral life cycle viral replication Viral RNA virus worldwide pandemic [DOI] 10.7150/ijbs.72663 PMC 바로가기 [Article Type] Review
Angiotensin 1-7 Stimulates Proliferation of Lung Bronchoalveolar Progenitors-Implications for SARS-CoV-2 InfectionArticle Published on 2022-07-022023-07-09 Journal: Cells [Category] COVID19(2023년), [키워드] ACE2 alveolar type 2 cells Angiotensin 1–7 bronchoalveolar stem cells COVID-19 lung epithelial cells. NLRP3 inflammasome RAAS [DOI] 10.3390/cells11132102 PMC 바로가기
Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatmentResearch article Published on 2022-07-012022-10-05 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] Activation acute respiratory syndrome Analysis analyzed Anti-inflammatory therapy apoptotic ASC Blood cDNA cell line circulating monocyte circulating monocytes coding confocal microscopy coronavirus COVID-19 Critically ill cytokine cytokine secretion Cytokine storm syndrome disease dissect driving effective Efficacy Evidence Frame IL-1 receptor antagonist IL-1β in vitro Infection Inflammasome inflammasomes Inflammation Inflammatory inflammatory parameters manifestation maturation mechanism NLRP3 NLRP3 inflammasome objective ORF3a pathway Patient patients with COVID-19 Phenotypes Plasma cytokine receptor protein reducing mortality regulated respond Result RNA sequencing SARS-CoV-2 SARS-CoV-2 protein secrete secretion severe coronavirus disease severe COVID-19 patient severe pneumonia shown Spontaneous transfection Treatment Trigger with COVID-19 [DOI] 10.1016/j.jaci.2022.05.029 [Article Type] Research article
Cyanidin-3-O-glucoside and Peonidin-3-O-glucoside-Rich Fraction of Black Rice Germ and Bran Suppresses Inflammatory Responses from SARS-CoV-2 Spike Glycoprotein S1-Induction In Vitro in A549 Lung Cells and THP-1 Macrophages via Inhibition of the NLRP3 Inflammasome Pathway시아니딘-3-O-글루코사이드 및 피오니딘-3-O-글루코사이드-풍부 검정 쌀 배아 및 겨 분획은 A549 폐 세포 및 THP-1 대식세포에서 SARS-CoV-2 스파이크 당단백질 S1-유도 시험관 내 염증 반응을 억제합니다 NLRP3 Inflammasome 경로의 억제Article Published on 2022-06-302022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] A549 Activation anthocyanin anthocyanins Anti-inflammation anti-inflammatory property ASC attenuate benefit black black rice bran C3G Cell cell lines Concentration counteraction COVID-19 COVID-19 infection cytokine secretion dose-dependent manner downregulation Effect exhibited exposure to fraction functional functional food Gene Expression Germ Health health benefits HPLC IL-18 IL-1β IL-6 immune cells in vitro model Inflammasome Inflammation Inflammatory Inflammatory response Inflammatory responses inhibition innate immune cell Innate immune cells long-COVID lung tissue Macrophage macrophages mechanism NF-kB NLRP3 NLRP3 inflammasome P3G pathway post-acute COVID protective effect Protective effects Protein protein level protein levels reported response responsible Rice S1 subunit SARS-CoV-2 spike spike glycoprotein spike glycoprotein S1. THP-1 treated was determined [DOI] 10.3390/nu14132738 PMC 바로가기 [Article Type] Article
Circulatory Exosomes from COVID-19 Patients Trigger NLRP3 Inflammasome in Endothelial CellsCOVID-19 환자의 순환 엑소좀은 내피 세포에서 NLRP3 인플라마좀을 유발합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation of caspase-1 acute respiratory syndrome acute respiratory syndrome coronavirus augmentation blood flow cargo caspase caspase-1 Cell Circulatory Coagulation Coagulopathy combating Control coronavirus coronavirus 2 COVID-19 Culture culture medium Cytokine storm demonstrated drug endothelial Endothelial cell endothelial cells ENhance examined Exosome Exosomes exposure to extracellular vesicle Extracellular vesicles Health health problem healthy donors help highlight IL-1β Immunopathogenesis induce Infection Inflammasome Inflammation Inflammatory response inhibit interleukin interleukin-1β investigator liver mechanism medium Mild Mild disease molecular molecular mechanism mRNA expression Multiple organ damage NLRP3 NLRP3 inflammasome opens organ organ damage Pathogenesis Patient plasma predicted Prevent respiratory resting resulting SARS-CoV-2 SARS-COV-2 infection secretion Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient severe COVID-19 patients significantly the vaccine Therapies Trigger Vaccine Venous Thromboembolism with mild disease [DOI] 10.1128/mbio.00951-22 PMC 바로가기 [Article Type] Article