Association between tocilizumab treatment of hyperinflammatory patients with COVID-19 in a critical care setting and elevated incidence of hospital-acquired bacterial and invasive fungal infections중환자 환경에서 COVID-19 과염증 환자의 토실리주맙 치료와 병원 획득 세균 및 침습성 진균 감염의 발병률 증가 사이의 연관성Article Published on 2022-08-012022-09-12 Journal: The Journal of hospital infection [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] 95% CI 95% confidence interval adverse event Bacterial Characteristics COVID-19 COVID-19 mortality COVID-19 secondary infections Critical care elevated Frequency Fungal infection fungal infections greater hospital discharge Hospital stay Hyperinflammatory ICU ICU admission incidence increase in inhibitor intensive care interleukin-6 invasive Invasive mechanical ventilation median Mortality Non-COVID-19 occurred outcome Patient patients with COVID-19 reduce reported retrospective review serious infection severe coronavirus disease severe COVID-19 significantly higher significantly lower Survivors Tocilizumab Treatment [DOI] 10.1016/j.jhin.2022.04.007 PMC 바로가기 [Article Type] Article
Funding Sources of Therapeutic and Vaccine Clinical Trials for COVID-19 vs Non-COVID-19 Indications, 2020-2021COVID-19 대 비-COVID-19 적응증에 대한 치료 및 백신 임상 시험의 자금 출처, 2020-2021Article Published on 2022-08-012022-09-11 Journal: JAMA Network Open [Category] 임상, [키워드] addressed clinical clinical trial clinical trials Cohort collected COVID-19 COVID-19 therapeutics COVID-19 vaccine cross-sectional cross-sectional study effective Evidence examined followed by funding funding source indications maintain market MOST Non-COVID-19 number outcome pandemic Phase 1 public sector reached Registered Regulatory required Research research and development Source therapeutic Therapeutics Trial Vaccine [DOI] 10.1001/jamanetworkopen.2022.26892 PMC 바로가기 [Article Type] Article
Prognostic Value of Mid-Region Proadrenomedullin and In Vitro Interferon Gamma Production for In-Hospital Mortality in Patients with COVID-19 Pneumonia and Respiratory Failure: An Observational Prospective StudyCOVID-19 폐렴 및 호흡부전 환자의 병원 내 사망률에 대한 중간 지역 Proadrenomedullin 및 체외 인터페론 감마 생산의 예후적 가치: 관찰적 전향적 연구Observational Study Published on 2022-07-302022-09-11 Journal: Viruses [Category] MERS, 바이오마커, 임상, [키워드] 95%CI Admission Adult patients adverse outcome adverse outcomes AUROC best Biomarker cause characterized Coagulopathy Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 pneumonia COVID-19 vaccination cut-off cut-off point Deceased dysregulation endothelial damage enrolled Enrollment Evidence evidence of females Gamma groups Hospital mortality Hospitalization IFNγ immune dysregulation Immune suppression Immunocompromised patients in vitro in-hospital mortality infection risk interferon interferon gamma median age mid-region proadrenomedullin MONITOR Mortality MR-proADM Negative predictive value Non-COVID-19 observational study PaO2:FiO2 Patient patients with COVID-19 Pneumonia predict Predictive value predictive value) Production Prognostic factor Prospective quantiferon monitor. radiologic respiratory Respiratory failure SARS-CoV-2 sensitivity significantly specificity subset survivor the median value were measured with COVID-19 with infection [DOI] 10.3390/v14081683 PMC 바로가기 [Article Type] Observational Study
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysisCOVID-19로 병원에 입원한 환자의 바리시티닙(RECOVERY): 무작위, 통제, 공개 라벨, 플랫폼 시험 및 업데이트된 메타 분석Meta-Analysis Published on 2022-07-302022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 28-day mortality 95% CI age-adjusted rate ratio allocation Baricitinib benefit by mouth cause Corticosteroid Corticosteroids COVID-19 COVID-19 therapy death deaths died discharge eight enrolled evaluate Evidence hospital hospitalised Including Infection inhibitor Innovation intention-to-treat population ISRCTN Jak JAK inhibitor jak inhibitors janus Janus kinase Medical Research Council Meta-analysis mouth nine Non-COVID-19 once daily Open-label outcomes Patient Platform trial Primary outcome Proportional reduction randomisation randomised randomised controlled trial Randomised Evaluation Randomly randomly assigned patient rate ratio receive receiving recorded recovery RECOVERY trial reduce mortality reduced reduction in mortality Registered risk of death significantly Standard of care suggested thrombosis Tocilizumab Treatment Trial trials usual care usual care alone usual care group was done with COVID-19 [DOI] 10.1016/S0140-6736(22)01109-6 PMC 바로가기 [Article Type] Meta-Analysis
Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection기관지 흡인물의 다중 단백질 프로파일링은 SARS-CoV-2 감염에 이차적으로 ARDS가 있는 중환자에서 질병, 사망률 및 호흡기 후유증과 관련된 징후를 나타냅니다.Multicenter Study Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome adverse outcomes AGR2 all-cause mortality ARDS association BAS bronchial bronchial aspirate confounding factors correlated COVID-19 COVID-19 patients Cox regression model Cox regression models Critically ill Critically ill patient critically ill patients CST5 Decision making determinant disease pathogenesis DPP7 ENTPD2 expressed Factor FCRL1 highest hospital discharge host response ICU ICU – intensive care unit identify IL-1α immune IMV intensive care Invasive mechanical ventilation Kaplan-Meier curve Kaplan-Meier curves KYAT1 lung cells Lung function mechanism molecular Mortality mortality risk multicenter study NADK Non-COVID-19 Non-COVID-19 patients nonsurvivor nonsurvivors NQO2 NTF4 OSM outcomes Pathogenesis pathology Poor Protein proteomic proteomics proximity extension assay PTN quantified radiological feature radiological features random Random forest reduced respiratory respiratory distress Respiratory distress syndrome reveal risk Risk assessment SARS-COV-2 infection SRPK2 subgroup subgroups supported Survivors the disease the strongest THOP1 TRAIL TSS TYMP Viral viral infectivity were used with COVID-19 [DOI] 10.3389/fimmu.2022.942443 PMC 바로가기 [Article Type] Multicenter Study
An Empirical Analysis of an Optimized Pretrained Deep Learning Model for COVID-19 DiagnosisCOVID-19 진단을 위한 최적화된 사전 훈련된 딥 러닝 모델의 실증 분석Article Published on 2022-07-272022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] accelerated approach battle bioinformatics clinicians and researcher COVID-19 COVID-19 disease COVID-19 outbreak datasets deep deep learning Deep Learning Method diagnosed Diagnosis diagnosis of COVID-19 died evaluated fine-tune Frame healthy learning lung Model Non-COVID-19 patients with COVID-19 platform Pneumonia Predictive predictive models referred to researcher separate experiments Treatment virus Volume were used [DOI] 10.1155/2022/9771212 PMC 바로가기 [Article Type] Article
Longitudinal Serum Proteome Characterization of COVID-19 Patients With Different Severities Revealed Potential Therapeutic Strategies다양한 중증도를 가진 COVID-19 환자의 세로 혈청 프로테옴 특성이 잠재적인 치료 전략을 드러냄Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation alteration Analysis Asymptomatic asymptomatic patient asymptomatic patients caused characterization cholesterol cholesterol metabolism Cluster cluster analysis coagulation cascade collected complement Complement activation control group control groups COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Disease progression dysregulation effective expand global healthcare heterogeneity Hierarchical hierarchical cluster analysis immune response individuals involved longitudinal metabolism Mild moderate Moderate COVID-19 moderate COVID-19 patients molecular Non-COVID-19 not recovered Pathogenesis pathophysiological Patient patients performed PLGLB1 Potential potential therapeutic target potential therapeutic targets progression Protein Proteins proteomic proteomics restored Revealed SARS-CoV-2 serum serum biomarker serum biomarkers Serum level serum sample serum samples severity Strategy symptomatic Treatment understanding [DOI] 10.3389/fimmu.2022.893943 PMC 바로가기 [Article Type] Article
SARS-CoV-2-Specific Adaptive Immunity in COVID-19 Survivors With Asthma천식이 있는 COVID-19 생존자의 SARS-CoV-2-특이적 적응 면역Article Published on 2022-07-182022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adaptive allergy analyzed Asthma asthmatic asthmatic patient benefit Blood Cell Clinical characteristics convalescent correlated COVID-19 COVID-19 patient discharge eosinophil Follow-up healthy control Humoral immunity immune immune memory Immunity individual Lymphocyte subsets memory B cell memory T cells NAb NAbs Neutralization assay Neutralizing antibodies no statistical difference Non-COVID-19 not significantly different Patient percentages positively correlated SARS-CoV-2 pseudotyped virus SARS-CoV-2 specific antibodies SARS-CoV-2-specific neutralizing antibody skewed subjects survivor T cell T cell response T cell responses Th1 Th17 cell Treg Treg cell virus infection virus-specific T cell [DOI] 10.3389/fimmu.2022.947724 PMC 바로가기 [Article Type] Article
Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatmentResearch article Published on 2022-07-062022-10-05 Journal: Molecular Therapy [Category] 바이오마커, 변종, 임상, 치료기술, 치료법, [키워드] ACE2 activity/concentration biomarker in plasma/saliva soluble Angiotensin-Converting Enzyme 2 ACE2 acute respiratory syndrome age angiotensin-converting-enzyme Autopsy Biomarker clinical observation Concentration condition Control convalescent Corona virus coronavirus disease Coronavirus-2 COVID-19 COVID-19 disease COVID-19 patient disease disease severity dysregulation evaluate evaluated Hospitalization hospitalized COVID-19 patient human cell infect inverse correlation lung mACE2 marker membrane nadir no difference Non-COVID-19 offer Patient patients plasma Plasma marker plasmas quantitative test quarantine RAS pathway receptor reduced renin-angiotensin system restored sACE2 Saliva saliva marker SARS-CoV-2 SARS-CoV-2 diagnosis/treatment soluble ACE2 statistically therapeutic target tissue treat variations volunteers [DOI] 10.1016/j.omtm.2022.07.003 [Article Type] Research article
Audio texture analysis of COVID-19 cough, breath, and speech soundsResearch article Published on 2022-07-012022-10-05 Journal: Biomedical Signal Processing and Control [Category] 바이오마커, 치료기술, [키워드] Accuracy Analysis asthmatic Audio texture binary classification breath coronavirus disease cough COVID-19 COVID-19 negative diagnose experiments feature Haralick features healthy help highest initial screening LBP Local Local binary pattern Non-COVID-19 polymerase chain reaction positive remote monitoring resources reverse transcription RT-PCR Spectrogram speech was done was obtained [DOI] 10.1016/j.bspc.2022.103703 [Article Type] Research article