Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19COVID-19에 대한 활동을 입증 한 승인 된 약물의 선택과 관련된 독성 위험의 계산 결정Research Published on 2021-10-212022-08-31 Journal: BMC Pharmacology & Toxicology [Category] 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach approved approved drug Cardiotoxicity caused clinical assessment clinical trial clinical trials Compound computational tool coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment demonstrated disease drug Drug discovery excretion expected facilitate FIVE global pandemic healthcare in silico independent knowledge majority manuscript metabolism molecules non-toxic off-label Patient pharmacological Practitioner predict profile receive repurposing Repurposing drugs, hERG) researcher respiratory Result risk safety profile SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe pneumonia significantly Spread Stratification supplementary material therapeutic therapeutic agent therapy Toxicity treating COVID-19 Treatment treatment for COVID-19 Usage Vaccine Vaccines [DOI] 10.1186/s40360-021-00519-5 PMC 바로가기 [Article Type] Research
The Curious Case of Earthworms and COVID-19Perspective Published on 2021-10-142022-10-28 Journal: Biology [Category] COVID-19, [키워드] activate Anti-viral Bacteria can be used Charles Darwin coronavirus 2 COVID-19 COVID-19 vaccines Earthworm elicited example Gene Expression Genome human SARS-CoV-2 immune immune system Immunity in vivo information invertebrate kill lysenin mechanism mechanisms Nanoparticles non-toxic organism potential risk Protein Proteins respiratory SARS-CoV-2 Scientific community shown simple therapeutic Toxicity unique virus viruses worm [DOI] 10.3390/biology10101043 PMC 바로가기 [Article Type] Perspective
Plant Alkaloids Inhibit Membrane Fusion Mediated by Calcium and Fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 Fusion PeptidesArticle Published on 2021-10-102022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] alkaloid alkaloids alteration antiviral action antiviral therapy calcium cholesterol composed Compound concentrations coronavirus COVID-19 decrease demonstrated Effect effective Efficiency fluorescence microscopy fragment fusion fusion peptide greater in vitro indicated inhibit inhibitory investigated knowledge Lipid Mediated membrane membrane fusion MERS-CoV non-toxic Novel coronavirus pandemic peptides Phosphatidylcholine physical piperine plant Prevent progeny reduce SARS-CoV2 scattering shown significant changes in significantly suppress tested Vero Cell Vesicle viral fusion inhibitor [DOI] 10.3390/biomedicines9101434 PMC 바로가기 [Article Type] Article
Evaluation of at-home methods for N95 filtering facepiece respirator decontaminationArticle Published on 2021-10-052022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] authorization biomedical engineering COVID-19 COVID-19 pandemic Disease prevention drug effective Emergency food group Healthcare professional highlighting identify non-toxic protocol Respirator reuse Safe [DOI] 10.1038/s41598-021-99129-8 PMC 바로가기 [Article Type] Article
Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19Chemistry Published on 2021-09-102022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] activated acute respiratory syndrome adaptive immune system administration alteration antioxidant caused CD4 CD8 Cell change changes in clinical trial complementary Concentration contributing to controlling coronavirus 2 COVID-19 Critically ill patient cytokine disease doses dysregulation energy metabolism epithelial cells Excessive activation form Glucose glycolytic pathway help hyperactivity hyperglycolysis IFN immune system Importance Infection Infectious disease Inflammation inhibitors innate immune innate immune system metabolism non-toxic organism oxidative phosphorylation pathway patients poor prognosis pro-inflammatory cytokine pro-inflammatory cytokines promote reactive oxygen species reduce respiratory epithelial cell SARS-CoV-2 SARS-CoV-2-infected cells secretion suggested syndrome T cells the disease therapeutic strategy thought Treatment underlie understanding viral replication Vitamin C with COVID-19 [DOI] 10.3389/fchem.2021.685196 PMC 바로가기 [Article Type] Chemistry
Molecular docking and dynamic simulation of conserved B cell epitope of SARS-CoV-2 glycoprotein Indonesian isolates: an immunoinformatic approachResearch Article Published on 2021-08-162022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] Activation acute respiratory syndrome addition Antigen antigenic approach B cell B cell epitope BCR binding Brazil calculated Candidates carried CD4+ cell China complex conserved conserved region. coronavirus country COVID-19 differentiation docking epitope gene sequence GISAID histocompatibility complex HLA Immunoinformatic India Indonesia Infectious disease investigated isolate isolates leukocyte lowest memory response MHC-II molecular NCBI non-toxic peptide predicted produced receptor Region SARS-CoV-2 SARS-CoV-2 glycoprotein SARS-CoV-2 isolate SARS-CoV-2 spike glycoprotein sequence South Africa spike glycoprotein T cell The United States the vaccine Toxicity United Kingdom Vaccine vaccine candidate Virus neutralization Wuhan [DOI] 10.12688/f1000research.54258.1 PMC 바로가기 [Article Type] Research Article
Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease InhibitorsArticle Published on 2021-08-122022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] activities affecting antiviral activity Antiviral effect binding binding affinity blocked catalytic cellular COVID-19 COVID-19 outbreak derivative dimeric Diseases drug indicated inhibitors inhibitory inhibitory activity lysine M pro mechanism of action non-toxic Papain-like protease peptide peptide-based peptides potent protease public health system reported SARS-CoV-2 SARS-COV-2 infection Spread synthetic peptide treat viral infections were assessed [DOI] 10.3390/molecules26164896 PMC 바로가기 [Article Type] Article
Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesisResearch Published on 2021-07-162022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] accelerated ADME ADMET alkaloid anti-SARS-CoV-2 binding affinity binding energy clinical trials complex Compound compounds COVID-19 COVID-19 vaccine distribution drug-likeness effective exhibited highlight HIV reverse transcriptase in silico in viral inhibitors of SARS-CoV-2 inhibitory investigated involved Ligand mechanism metabolism molecular molecular docking non-structural protein non-structural proteins non-toxic NSP Nsp3 Nsps Pathogenesis Pathways Polyphenolics predicted property Result SARS-CoV-2 SARS-CoV-2 pathogenesis Seven Structure supplementary material terpenoids Toxicity transcriptase Treatment vital role [DOI] 10.1186/s43141-021-00206-2 PMC 바로가기 [Article Type] Research
Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of M pro and Its Antiviral Activity in Cells against SARS-CoV-2Article Published on 2021-06-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] activity Antiviral antiviral drug catalytic complementary Compound concentrations COVID-19 pandemic derivatives docking experiment driven by experimental evidence explain flavanols flavonol GLN189 Hydrogen bond in vitro inaccessible infected cell inhibit inhibition inhibitor M pro main protease mechanism molecular target non-toxic produced protease Protease activity PROTECT quercetin reported residue SARS-CoV-2 SARS-CoV-2 replication Selenium vaccination viral replication [DOI] 10.3390/ijms22137048 PMC 바로가기 [Article Type] Article
An Immunoinformatics Approach for SARS-CoV-2 in Latam Populations and Multi-Epitope Vaccine Candidate Directed towards the World’s PopulationArticle Published on 2021-06-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adjuvant affecting alleviate antibody production antigenic antigenic peptide B lymphocyte Beta bioinformatics candidate candidate vaccine common allele complexes Consequences conserved Contagion coronavirus Coverage COVID-19 Dynamics Final health system help histocompatibility complex HLA HLA-A HLA-B HLA-C identify immune response immunological in silico LATAM Latin America non-allergenic non-toxic PADRE pandemic peptide peptides physicochemical Population predict proteomes public health crisis reduce mortality Region responses risk of infection Safe SARS-CoV-2 SARS-CoV-2 protein three-dimensional structure Vaccine [DOI] 10.3390/vaccines9060581 PMC 바로가기 [Article Type] Article