All-cause mortality and disease progression in SARS-CoV-2-infected patients with or without antibiotic therapy: an analysis of the LEOSS cohortOriginal Paper Published on 2021-10-082022-10-29 Journal: Infection [Category] COVID-19, COVID19(2023년), SARS, [키워드] age all-cause mortality analyses Analysis analyzed antibiotic antibiotic stewardship Antibiotic therapy Antibiotic treatment antibiotic use Antibiotics Bacterial calculated Cohort Comorbidity confounder coronavirus disease correlation COVID-19 COVID-19 patients Critical disease Disease progression Effect Gender had no IMPROVE inclusion criteria LEOSS less Local Mortality not correlated Patient PCT positive primary endpoint Probability procalcitonin progression reported Result SARS-CoV-2-infected patient Secondary endpoints significantly significantly increased the primary endpoint treated [DOI] 10.1007/s15010-021-01699-2 PMC 바로가기 [Article Type] Original Paper
Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection증상 및 무증상 SARS-CoV-2 감염에 대한 보호 상관관계Article Published on 2021-09-292022-09-10 Journal: Nature Medicine [Category] MERS, SARS, 변종, 임상, 진단, [키워드] Alpha analyzed Anti-RBD antibodies Anti-spike antibody antibody levels Antibody Units assays asymptomatic infection asymptomatic infections AZD1222 B.1.1.7 binding binding and neutralizing antibodies binding antibody unit binding antibody units can be used ChAdOx1 ChAdOx1 nCoV-19 correlated COVID-19 vaccine COVID-19 vaccines determine Efficacy elicited estimate extrapolation facilitate immune marker immune markers immune response Infectious diseases International international unit majority marker neutralization neutralization titer neutralization titers Neutralizing antibodies neutralizing antibody normalized not correlated Population Predictive pseudovirus Randomized recipients reduced risk SARS-CoV-2 SARS-COV-2 infection second dose significance level symptomatic and asymptomatic symptomatic infection These data Trial United Kingdom Vaccine vaccine efficacy Vaccines variant of SARS-CoV-2 were measured [DOI] 10.1038/s41591-021-01540-1 PMC 바로가기 [Article Type] Article
Clinical Characteristics of Newborns Born to Mothers with COVID-19Article Published on 2021-09-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] APGAR score Breastfeeding clinical Clinical characteristics collected control group COVID-19 Diagnosis distress group Infant infected with SARS-CoV-2 Infection medical records moderate MOST mother Neonate Newborn Newborns not correlated not differ outcome pandemic Poland positive Pregnancy respiratory distress Respiratory failure respiratory insufficiency Respiratory Support risk SARS-CoV-2 SARS-CoV-2-positive mother separation tachypnea the patient the study group transient tachypnea of the newborn virus was tested with COVID-19 women [DOI] 10.3390/jcm10194383 PMC 바로가기 [Article Type] Article
The impact of the COVID-19 pandemic on patterns of attendance at emergency departments in two large London hospitals: an observational studyObservational Study Published on 2021-09-232022-10-04 Journal: BMC health services research [Category] SARS, 임상, [키워드] 95%CI Accident Admission analysed Analysis And emergency average avoidance calibrated changed college COVID-19 COVID-19 pandemic decrease Emergency emergency department England Frame Health Service healthcare hospital Hospital admission hospitalisation in-hospital mortality lockdown London mortality risk National NHS Non-COVID-19 not correlated not differ observé outcome patients without COVID-19 proportion public health measure regions Result seeking Streamline supplementary material Transport Trust [DOI] 10.1186/s12913-021-07008-9 PMC 바로가기 [Article Type] Observational Study
Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy이탈리아의 초기 전염병 기간 동안 COVID-19 환자의 치명적인 결과와 관련된 독특한 대사 프로필Observation Published on 2021-09-012022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 바이오마커, 진단, [키워드] alteration best change clinical condition Cohort Complete contribute coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients described Diagnosis diagnostic disease severity epicenter Fatal outcome identify independent Infection IRCCS Italian Italy lombardy metabolic metabolome metabolomics moderate moment mortality rate not correlated outcome oxygen oxygen demand pandemic Potential biomarker potential biomarkers predictive biomarkers profile Prognosis Prognostic factor Region SARS-COV-2 infection severe cases severe symptom severity starting point the disease the patient therapeutic Therapeutic treatment understanding unique [DOI] 10.1128/Spectrum.00549-21 PMC 바로가기 [Article Type] Observation
Are adipokines the missing link between obesity, immune response, and outcomes in severe COVID-19?Observational Study Published on 2021-09-012022-10-05 Journal: International journal of obesity (2005) [Category] 바이오마커, 임상, [키워드] Adipokine baseline BMI Characteristics clinical Concentration concentrations correlated COVID-19 COVID-19 patient cytokine dysregulated immune response enrolled Glucose glycemia IL-1β IL-6 immune response Inflammatory mediators intensive care Leptin life-threatening mechanical ventilation metabolism Non-COVID-19 non-COVID-19 patient not correlated not significantly different obesity outcome outcomes Patient plasma reported required severe COVID-19 severe pneumonia severity significantly single-center study SOFA score suggested two groups [DOI] 10.1038/s41366-021-00868-5 PMC 바로가기 [Article Type] Observational Study
Children with congenital colorectal malformations during the UK Sars-CoV-2 pandemic lockdown: an assessment of telemedicine and impact on healthOriginal Article Published on 2021-08-052022-10-28 Journal: Pediatric surgery international [Category] Coronavirus, MERS, SARS, [키워드] Anorectal malformation Anxiety bowel Care change children conditions correlated COVID COVID-19 Deterioration disease dysfunction Follow-up functional Health Hirschsprung’s disease Hirschsprung’s disease inventory lockdown malformation not correlated outcome pandemic parent parental pilot study predicted Quality of life questionnaire ranged reported Result SARS-CoV-2 severity supplementary material Telemedicine was used were assessed [DOI] 10.1007/s00383-021-04971-6 PMC 바로가기 [Article Type] Original Article
Inactivation of SARS-CoV-2 by Simulated Sunlight on Contaminated SurfacesResearch Article Published on 2021-07-212022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, SARS, [키워드] absence acute respiratory syndrome clinical condition conditions Contaminated coronavirus dependent on elevated emerging disease environmental survival experiments greater hidden inactivated inactivation intensity interfering substances L-type strains Lineage majority moderate not correlated occur patients persistence SARS-CoV-2 sensitivity Spread stability stainless steel strain Sunlight surface survival temperature transmission of SARS-CoV-2 unlikely variant viability virus viruses [DOI] 10.1128/Spectrum.00333-21 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Host Receptor ACE2 Protein Expression Atlas in Human Gastrointestinal TractCell and Developmental Biology Published on 2021-06-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 ACE2 protein acute respiratory syndrome analyzed antibody Atla Cancer cancer cell cancers CCK-8 cells Colon Colon cancer coronavirus correlation counting death digestive distribution enzyme expressed expression expression level expression pattern Gastrointestinal gastrointestinal cancers gastrointestinal tract heterogeneous host cell Human IHC immunohistochemistry in vitro independent infect infected with SARS-CoV-2 Interaction liver Liver cancer not affect not correlated pancreas pancreatic Pancreatic cancer paraffin-embedded Patient Prognosis prognosis of patient Prognostic marker proliferation proportion protein expression receptor Result SARS-CoV-2 significantly significantly increased staining survival Symptoms tissue tissues tract tumor cell line was tested [DOI] 10.3389/fcell.2021.659809 PMC 바로가기 [Article Type] Cell and Developmental Biology
ACE2 correlates with immune infiltrates in colon adenocarcinoma: Implication for COVID-19Research article Published on 2021-06-012022-10-05 Journal: International immunopharmacology [Category] Coronavirus, 유전자 메커니즘, [키워드] ACE2 ACE2 expression ACE2 gene Analysis association Cancer Colon Colon cancer conditions coronavirus disease COVID-19 COVID-19 pandemic demonstrated digestion evaluate expression expression pattern functional enrichment health emergency highlight immune Immune cell infiltration indicated individual infected with SARS-CoV-2 Methylation mRNA negative correlation not correlated novel outcome outcomes pandemic pathway Patient patient survival patients Prognosis promoter protein level reported SARS-COV-2 infection survival susceptibility tissue tissues upregulation Vitamin [DOI] 10.1016/j.intimp.2021.107568 [Article Type] Research article