A CRISPR-based ultrasensitive assay detects attomolar concentrations of SARS-CoV-2 antibodies in clinical samplesCRISPR 기반 초고감도 분석은 임상 샘플에서 SARS-CoV-2 항체의 원자 농도를 감지합니다.Article Published on 2022-08-092022-09-11 Journal: Nature Communications [Category] SARS, 바이오마커, 진단, 치료기술, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Antibody detection classic clinical clinical sample clinical samples Clinical use clinically collected Concentration CRISPR detect diagnostics General population homogeneous immunoassay immunoassays kidney transplant recipient Laboratory large cohort nucleic acid Nucleic acid detection nucleic acids point-of-care powerful tool Proteins Quantitative analysis SARS-CoV-2 antibody sensitivity serum serum sample serum samples shown simplicity specificity translate [DOI] 10.1038/s41467-022-32371-4 PMC 바로가기 [Article Type] Article
Electrochemical Detection of a Few Copies of Unamplified SARS-CoV-2 Nucleic Acids by a Self-Actuated Molecular System자가 작동 분자 시스템에 의한 증폭되지 않은 SARS-CoV-2 핵산의 전기화학적 검출Randomized Controlled Trial Published on 2022-08-032022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] acid assays Biomarker Biomarkers Chain Reaction copy detect detection Efficiency Graphene increase lack magnitude Modification modulate nasopharyngeal sample Nasopharyngeal samples nucleic acid nucleic acids probe response SARS-CoV-2 SARS-CoV-2 RNA Square wave System tentacle this system [DOI] 10.1021/jacs.2c02884 PMC 바로가기 [Article Type] Randomized Controlled Trial
CRISPR-based point-of-care diagnostics incorporating Cas9, Cas12, and Cas13 enzymes advanced for SARS-CoV-2 detectionSARS-CoV-2 검출을 위해 고급 Cas9, Cas12 및 Cas13 효소를 통합한 CRISPR 기반 현장 진료 진단Review Published on 2022-08-012022-09-11 Journal: Journal of biochemical and molecular toxicology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Beta beta coronavirus Cas12 Cas13 Cas9 Chain Reaction Characteristics clustered regularly interspaced short palindromic repeat Contamination coronavirus CRISPR CRISPR-Cas Diagnosis diagnostic Diagnostic strategies diagnostic system diagnostics disease disorder Efficiency enzyme global pandemic gold gold standard highlighting Intervention management Molecular diagnosis nucleic acid nucleic acids outbreak pathogen point-of-care Prognosis provide reagents Research respiratory Reverse transcription-polymerase chain reaction RPA RT-LAMP SARS-CoV-2 SARS-CoV-2 detection sensitivity Sensitivity and specificity Sickness simplicity specificity speed Spread Viral [DOI] 10.1002/jbt.23113 PMC 바로가기 [Article Type] Review
Detection of SARS-CoV-2 in the air in Indian hospitals and houses of COVID-19 patientsResearch article Published on 2022-08-012022-10-05 Journal: Journal of Aerosol Science [Category] 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome Airborne transmission analyzed asked Characteristics Closed-room air collected conditions coronavirus coronavirus disease COVID COVID-19 COVID-19 patient detection doffing Evidence hospital Hospital air hospitals Hyderabad ICU ICUs Infection involved nucleic acids Patient Personal protective equipment PPE Precaution Prevent provide sampling strategy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severity short duration Spread symptomatic patient Transmission Transport viability viral shedding virus were used [DOI] 10.1016/j.jaerosci.2022.106002 [Article Type] Research article
Metagenomic Next-Generation Sequencing Reveals the Profile of Viral Infections in Kidney Transplant Recipients During the COVID-19 PandemicMetagenomic 차세대 시퀀싱은 COVID-19 팬데믹 기간 동안 신장 이식 수혜자의 바이러스 감염 프로필을 보여줍니다Article Published on 2022-07-112022-09-11 Journal: Frontiers in Public Health [Category] 치료기술, [키워드] Analysis BALF Biomarker Blood Blood samples Bronchoalveolar lavage fluid CMV compared and analyzed COVID-19 COVID-19 pandemic cytomegalovirus database detection rate dominant higher risk IMPROVE indicated Infection JC polyomavirus kidney kidney transplant recipient kidney transplant recipients Kidney transplantation metagenomic Metagenomic next-generation sequencing Next-generation sequencing nucleic acid nucleic acids profile recipient rejection reveal sequence simian virus torque teno virus Transplant Urine viral infection viral infections viral nucleic acid viral nucleic acids virus virus infection viruses [DOI] 10.3389/fpubh.2022.888064 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 Specific Antibodies in Saliva Samples타액 샘플에서 SARS-CoV-2 특이적 항체 검출Article Published on 2022-07-082022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] analyzed conversion rates coronavirus coronavirus disease COVID-19 detection diagnose diagnosed with COVID-19 Diagnosis diagnostic diagnostic test different time point different time points early diagnosis enrolled Evidence Hospitalization IgA IgG and IgM IgG level IgM Immunoglobulin immunoglobulins limit Molecular assay molecular assays nasopharyngeal nasopharyngeal sampling Nasopharyngeal swab nasopharyngeal swabs nucleic acid nucleic acids Patient positive rate positive rates recent Saliva saliva IgA. Sample SARS-CoV-2 serum serum samples Shenzhen Specific specimen Viral viral nucleic acid viral nucleic acid detection viral nucleic acids were measured [DOI] 10.3389/fimmu.2022.880154 PMC 바로가기 [Article Type] Article
CRISPR-ENHANCE: An enhanced nucleic acid detection platform using Cas12aArticle Published on 2022-07-012023-07-06 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), [키워드] Cas12a CL7 COVID-19 CRISPR CRISPR/Cas detection DETECTR diagnostics ENhance Fluorescence lateral flow assay nucleic acids Protein purification RT-LAMP SARS-CoV-2 [DOI] 10.1016/j.ymeth.2021.02.001
Construction of SHERLOCK-based sgRNA for SARS-CoV-2 Diagnostics from IndonesiaArticle Published on 2022-07-012023-07-10 Journal: New Microbiologica [Category] COVID19(2023년), [키워드] Genomics nucleic acids Pandemics SARS-CoV-2
CRISPR-based assays for rapid detection of SARS-CoV-2SARS-CoV-2의 신속한 검출을 위한 CRISPR 기반 분석Review Published on 2022-07-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] best COVID-19 CRISPR CRISPR Diagnostics diagnosis of SARS-CoV-2 Diagnostic advancements diagnostic test diagnostic tests diagnostics effective effort Epidemiology Establishing global public health gold gold standard healthy individual healthy individuals infected patient Instrumentation isothermal limitation molecular testing nucleic acid nucleic acids overcome pandemic quarantine reagent reagents required SARS-CoV-2 SARS-CoV-2 infected patients serological test Serological tests the disease Treatment while [DOI] 10.1016/j.ymeth.2020.10.003 PMC 바로가기 [Article Type] Review
Role of the cGAS–STING pathway in systemic and organ-specific diseases Reviews Published on 2022-06-222022-10-05 Journal: Nature reviews. Nephrology [Category] 바이오마커, 치료제, [키워드] activate activated Antiviral Autoimmune bind Cancer conserved cytokine dinucleotide disease DNA Endoplasmic reticulum ENhance enzyme explain genomic high affinity Immune cell immune response implicated Inflammatory response inhibitor interferon Kidney injury Ligand metabolism mitochondrial neurodegenerative nucleic acids nucleotide organ-specific pathway pro-inflammatory promote Protein recognize role sequence specificity stimulate stimulated triggered type I interferon viral infections viruses [DOI] 10.1038/s41581-022-00589-6 [Article Type] Reviews