oxidative damage – Page 3 – Communicable Diseases Research

COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm

Review Article

Published on 2020-09-092022-10-29
Journal: Oxidative Medicine and Cellular Longevity
[Category] COVID-19, MERS, SARS,

[키워드] activate acute respiratory distress adaptive addressed Anti-inflammatory ARDS Blood blunt boost bypassing carbohydrate Cell cell death central metabolism characterized clinical study complex COVID-19 patient cytokine production Cytokine storm decrease distress downregulate energy metabolism enzyme fat Fatality rate function Gene Expression GPR109A high mortality rate Human immune immune function Immunity include Infection Influenza virus inhibit innate immune response ketogenic limitation lung cell metabolic mice mitochondrial metabolism molecular NLRP3 inflammasome nucleotide outcome oxidative damage Patient pDC proliferation PROTECT Protective pyruvate raise reactive nitrogen specy reactive oxygen specy redox state responsible risk RNS ROS SARS-COV-2 infection shown Signaling storm symptom severity syndrome T cell proliferation T cell response therapy Transport Treatment virus-induced cytokine storm
[DOI] 10.1155/2020/6401341 PMC 바로가기 [Article Type] Review Article

Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic Complications

Article

Published on 2020-09-082022-10-30
Journal: Molecular neurobiology
[Category] COVID-19, MERS, SARS,

[키워드] activated addition Affect affecting Aminoacridine anti-inflammatory agents Anti-inflammatory drugs antimalarial Antimalarials Aortic body arachidonic acid blood vessels Brain endothelial cells carotid body Cell culture Central nervous system Chloroquine clinical trial CNS combating Complication coronavirus coronavirus disease Coronavirus replication COVID COVID-19 COX cPLA₂ cross cytokine Cytokine storm cytosolic Cytosolic phospholipase A₂ Dementia disorder DMT1 drug Effect Eicosanoids ENhance expression free radical Free radical damage free radical formation generate Glossopharyngeal nerve hippocampus Hydroxychloroquine Hypoxemia impair induce Inflammation Inflammatory response inhibit inhibiting inhibition inhibitor iron accumulation Iron transport isoform isoforms lung lysosomal enzymes lysosome Lysosomes mice Microcirculation microglia Microvessels Neuroinflammation Neurovascular Nucleus of the tractus solitarius organ oxidative damage oxidative stress PLA2G2D pro-inflammatory produced quinacrine reducing Respiratory centre resulting SARS SARS-CoV SARS-CoV-2 SARS-CoV-2 virus Secretory phospholipase A₂ Seizures severe cases shown silent sPLA₂ IID statins stroke the SARS-CoV-2 virus tissue TNF-α Treatment unique vagus nerve Vascular vascular dementia viral replication
[DOI] 10.1007/s12035-020-02093-z PMC 바로가기 [Article Type] Article

The Importance of Redox Status in the Frame of Lifestyle Approaches and the Genetics of the Lung Innate Immune Molecules, SP-A1 and SP-A2, on Differential Outcomes of COVID-19 Infection

Review

Published on 2020-08-252022-10-28
Journal: The Cochrane database of systematic reviews
[Category] COVID-19,

Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections

Review

Published on 2020-06-302022-10-29
Journal: International Journal of Molecular Sciences
[Category] COVID-19, SARS,

[키워드] addition anti-vimentin autoantibodies antibody antiviral strategy appear approach autoantigen Autoimmune disease Bacterial Cell cell activation cell surface cell surface vimentin cell types cellular processe cellular receptor complex contribute coronavirus cytoplasmic cytoskeletal Encephalitis Extracellular filament protein functions immune response implication in viral Infection Inflammation Injury Interaction interfere intermediate filaments Migration modulate Occurrence oxidative damage Pathogens pathophysiological pathophysiology Perspective Phosphorylation posttranslational modifications Potential Proinflammatory cytokine Protein receptor required SARS-CoV secreted shown target tissue damage tissue damage and repair vimentin vimentin–pathogen interactions viral pathogenesis viral pathogens virus viruses
[DOI] 10.3390/ijms21134675 PMC 바로가기 [Article Type] Review

A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa

녹농균에 대한 방어를 위해서는 보존된 미토콘드리아 감시 경로가 필요합니다

Research Article

Published on 2017-06-292022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activate activated Activation addition Bacterial battery Caenorhabditis Caenorhabditis elegans Cell cellular structure conserved Critical cytological damage Defense defense mechanisms described Diseases dysfunction Effect elegan elegans element Ethanol expand exposure to family functions genetics Health heat homeostasis Host host defense human pathogen hypothermia hypoxia Imbalance immune responses include increasingly indicate Infection innate immune response Innate immunity Interaction intestinal kill leads liquid mammals mechanism mechanisms mitigate mitochondrial organelle organism Organisms overlap overlapping oxidative damage P . aeruginosa pathogen Pathogens pathway Physiology Prevent Protein Pseudomonas aeruginosa pyoverdine recognizing Regulation required respond response secreted selective shown Stress stress response Surveillance threat Toxicity transcriptomics unique upregulation variety virulence
[DOI] 10.1371/journal.pgen.1006876 PMC 바로가기 [Article Type] Research Article

Disrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [ PSI + ] prion formation

피질의 액틴 세포골격을 교란하는 것은 효모 [PSI + ] 프리온 형성의 두 가지 뚜렷한 메커니즘을 나타냅니다.

Research Article

Published on 2017-04-032022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] abrogate abrogated Actin affected Affinity purification aggregate aggregates aggregation Analysis antioxidant component composed conditions cortical Deletion disease disrupt examined form forms fragmentation Frequency fungal identify implicated increase infectious agent infectious agents insoluble protein mass spectrometry mechanism misfolded protein misfolded proteins molecular MOST mutant mutants neurodegenerative occur overexpression oxidative oxidative damage oxidative stress oxidized Prevent Previous studies previous study prion Probability Protein Protein misfolding Proteins PSI reduced required thought transition translation Trigger undergo yeast yeast cell yeast cells
[DOI] 10.1371/journal.pgen.1006708 PMC 바로가기 [Article Type] Research Article