A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection초강력 4량체화된 ACE2 단백질은 SARS-CoV-2 바이러스 감염의 강화된 중화를 나타냅니다Article Published on 2021-05-192022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 신약개발, 치료제, [키워드] ACE-2 ACE2 ACE2 protein ACE2 receptor acute respiratory syndrome addition affected angiotensin angiotensin converting enzyme Anti-viral antibodies approaches binding block blocks complex coronavirus COVID-19 dimeric domain Drug discovery Efficacy enzyme Fc region forms human cells human immunoglobulin Immunoglobulin immunology Infection Interaction molecular weight monoclonal antibodies monomeric Mutation neutralization p53 Protein protein complex pseudovirus Quad receptor Receptor binding respiratory SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 pseudovirus SARS-CoV-2 virus SARS-CoV-2 virus infection Severe acute respiratory syndrome Spike protein the SARS-CoV-2 the spike protein therapeutic therapy unlikely variant Viral Viral antigen viral antigens virus infection [DOI] 10.1038/s41598-021-89957-z PMC 바로가기 [Article Type] Article
Liver Lipids of Patients with Hepatitis B and C and Associated Hepatocellular CarcinomaArticle Published on 2021-05-182023-06-03 Journal: International Journal of Molecular Sciences [Category] B형 간염, [키워드] ceramide p53 polyunsaturated phospholipids triacylglycerol [DOI] 10.3390/ijms22105297 PMC 바로가기 [Article Type] Article
Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteinsArticle Published on 2021-05-182022-10-04 Journal: Scientific Reports [Category] SARS, 임상, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody antibodies antibody applied binding Biotechnology cause clinical investigation clinical trial Coronavirus-2 COVID-19 disease domain Drug discovery ENhance etesevimab immunology Implementing IMPROVE Interaction limit magnitude methodological Molecular medicine neutralization p53 Protein pseudovirus infection SARS-CoV-2 SARS-CoV-2 antibody Spike protein Spike proteins the SARS-CoV-2 Therapeutic antibody variant variants of concern viral infection viral spike protein virus wildtype [DOI] 10.1038/s41598-021-89887-w PMC 바로가기 [Article Type] Article
Viral strategies for circumventing p53: the case of severe acute respiratory syndrome coronavirusArticle Published on 2021-03-052023-07-01 Journal: Current opinion in oncology [Category] SARS, [키워드] coronavirus Nsp3 p53 Replication RING finger and CHY zinc finger domain-containing protein 1 severe acute respiratory syndrome coronavirus 2 virus [DOI] 10.1097/CCO.0000000000000713 PMC 바로가기
Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populationsMycobacterium tuberculosis 감염에 대한 내성에 대한 게놈 차원의 연관성 연구는 3개의 별개 집단에서 10q26.2의 유전자좌를 확인합니다Research Article Published on 2021-03-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95%CI activating ADAM12 allele Analysis association C10orf90 characterized chromosome Cluster Cohort Contact decreased expression defined Diagnosis ENCODE Endemic enrolled epidemiological Evidence exposure to France French Genome-wide association study genome-wide significant genotyped household contact household contacts identify IFN-γ independent individual infected individual infected individuals Infection inter-individual interferon Interferon-gamma intronic region lead locus Lymphocytes monocyte Monocytes Mycobacterium tuberculosis natural history outcome p53 patients performed Population populations positive proportion Protective Release replicated selected shown skin Skin test South Africa subject Suppressor gene Test Th17 transcription factor TST Tuberculin tuberculin skin test Tuberculosis Tumor tumor suppressor tumor suppressor gene ubiquitin ligase upstream Variability variant variants [DOI] 10.1371/journal.pgen.1009392 PMC 바로가기 [Article Type] Research Article
Function and Regulation of Nuclear DNA Sensors During Viral Infection and TumorigenesisReview Published on 2021-01-112023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] cGAS hnRNPA2B1 IFI16 nuclear DNA sensor p53 tumorigenesis type I interferon [DOI] 10.3389/fimmu.2020.624556 PMC 바로가기 [Article Type] Review
Novel modulators of p53-signaling encoded by unknown genes of emerging virusesResearch Article Published on 2021-01-072022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] approach binding Cancer Cell de novo DNA Ebola experiment function functional functions genomic Hypothesis hypothetical identify infections Influenza Interaction interfere long non-coding RNA mechanism molecular New non-coding RNA novel Open reading frame p53 predicted Protein resource RNA viruses RNAs Signaling Systems biology tested transcription factor viral nucleic acid Viral protein Viral proteins virus viruses Zika Zika virus ZIKV [DOI] 10.1371/journal.ppat.1009033 PMC 바로가기 [Article Type] Research Article
Spatial and temporal roles of SARS-CoV PL pro -A snapshotSARS-CoV PL pro -A 스냅샷의 공간적 및 시간적 역할Review Published on 2021-01-012022-09-11 Journal: FASEB journal : official publication of the Federa [Category] 치료법, [키워드] 3CL pro accessory protein accessory proteins Antiviral appear autocleavage C-terminus can not cleave cleaved CoV replication cysteine cysteine protease dilemma domain E3 ubiquitin ligase envelope Factor inhibit inhibitor innate immune response Interaction interferon interferon-stimulated gene ISG15 its target protein its target proteins IκBα membrane motif NF-κB nonstructural protein nsp1 Nsp3 Nsps Nucleocapsid proteins p53 Papain Papain-like protease PLPro polyprotein polyproteins pp1a pp1ab promote protease Protein provide RCHY1 released Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 infections stimulator STING TNF ubiquitin unique Viral Zinc [DOI] 10.1096/fj.202002271 PMC 바로가기 [Article Type] Review
Computational and network pharmacology analysis of bioflavonoids as possible natural antiviral compounds in COVID-19Research article Published on 2020-12-232022-10-05 Journal: Informatics in Medicine Unlocked [Category] 치료제, [키워드] amentoflavone Analysis Antiviral Bioflavonoid Bioflavonoids complexes Compound COVID-19 docking Dynamics Effectiveness endoribonuclease glycyrrhizic acid In-silico study Inflammation inhibiting leukocyte Ligand MAPK MERS Middle East modulation molecular molecular docking Molecular docking study Molecular dynamics simulation Mulberroside natural antiviral network pharmacology Novel Coronavirus-2 oxidative stress p53 performed plant protease protein-ligand Proteins RBD respiratory S protein SARS CoV-2 SARS-CoV-2 protein selected signaling pathway Spike protein target proteins the receptor-binding domain therapy TNF trajectory transendothelial migration Treatment Wnt [DOI] 10.1016/j.imu.2020.100504 [Article Type] Research article
Anti–coronavirus disease 2019 (COVID‐19) targets and mechanisms of puerarin푸에라린의 항 코로나 바이러스 질병 2019 (COVID-19) 표적 및 메커니즘Original Article Published on 2020-11-262022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] Apoptosis B cell BCl2 binding CASP3 CASP8 caspase caspase 3 caspase 8 Cell COVID‐19 COVID‐19 disease docking effective EGFR epidermal epidermal growth factor FOS growth factor IL2 in silico inflammatory cascades interleukin interleukin 2 MAPK marker mechanism methodology modulation molecular docking molecular markers Necrosis network pharmacology nitric oxide nitric oxide synthase NOS3 oxidative stress p53 pathway Pathways pharmacological potential molecular Potential treatment PPARG PRKCA PRKCB Protein protein kinase protein p53 PTGS2 puerarin receptor RELA suppression target targets TNF TP53 treat Treatment tumour necrosis factor [DOI] 10.1111/jcmm.16117 PMC 바로가기 [Article Type] Original Article