pathophysiologic – Page 3 – Communicable Diseases Research

Repurposed pharmacological agents for the potential treatment of COVID-19: a literature review

COVID-19의 잠재적 치료를위한 용도 기반 약리학 적제 : 문헌 검토

Review

Published on 2021-11-272022-08-31
Journal: Respiratory Research [Category] MERS, SARS, 신약개발, 치료제,

Complement Mediated Hemolytic Anemias in the COVID-19 Era: Case Series and Review of the Literature

Immunology

Published on 2021-11-252022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] Activation Atypical Autoimmune autoimmune hemolytic anemia benefit CAD carried clinically Cold agglutinin disease complement Complement inhibitor complex Complication condition COVID-19 COVID-19 disease COVID-19 infection COVID19 vaccine disease dose greater Hemodialysis hemolytic hemolytic anemia hemolytic uremic syndrome include Infection inhibitor Laboratory LDH literature manuscript Mediated occur occurred Occurrence paroxysmal nocturnal hemoglobinuria pathophysiologic Patient Patient education patient population plasma Platelet Prophylaxis provided recognize required review Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Sery severity steroid subject therapeutic intervention Thrombotic complications Treatment Trigger uremic syndrome Vaccine warm
[DOI] 10.3389/fimmu.2021.791429 PMC 바로가기 [Article Type] Immunology

Janus kinase inhibitors and major COVID-19 outcomes: time to forget the two faces of Janus! A meta-analysis of randomized controlled trials

야누스 키나제 억제제와 코로나19 주요 결과: 야누스의 두 얼굴을 잊어야 할 때! 무작위 대조 시험의 메타 분석

Meta-Analysis

Published on 2021-11-012022-09-11
Journal: Clinical Rheumatology [Category] SARS, 임상,

[키워드] added Adult patients antibody production assigned Baricitinib benefit concerning coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 infection Cytokine storm database death disease ECMO Efficacy Endpoint ENhance evaluate extracorporeal membrane oxygenation global public health In-hospital Inflammatory response inhibitor Jak JAK inhibitor jak inhibitors janus Janus kinase Janus kinase inhibitor Kinase inhibitor Mechanical mechanical ventilation mechanism Meta-analysis Mortality nezulcitinib nightmare outcome outcomes pathophysiologic Patient patients with COVID-19 Randomized controlled trial Randomized controlled trials RCT RCTs reduction in risk risk reduction ruxolitinib searched significant decrease stages Standard of care subject Tofacitinib Treatment
[DOI] 10.1007/s10067-021-05884-4 PMC 바로가기 [Article Type] Meta-Analysis

Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine

Review

Published on 2021-10-312022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

COVID-19 in children: an approach for multisystem inflammatory syndrome

Review

Published on 2021-10-262022-10-31
Journal: Egyptian Pediatric Association Gazette [Category] COVID-19,

[키워드] acute respiratory syndrome Adults approach article cause characterized children clinical evidence clinical feature coronavirus coronavirus disease Coronavirus-2 Corticosteroids COVID-19 COVID-19 patients database diagnosed Diagnosis elevated exaggerated immune response exclusion Fever gastrointestinal involvement Hyperinflammatory Hyperinflammatory syndrome immunoglobulins Infection Inflammatory inflammatory markers information Intravenous immunoglobulin IVIG Kawasaki lack lower mortality management mechanism Mild symptom MIS-C multiorgan failure Multisystem inflammatory syndrome Organ failure pathophysiologic pathophysiology pediatric pediatrics Rash retrieved SARS-CoV-2 SARS-COV-2 infection searched Specific subsequent syndrome Tocilizumab Topic treated Trial
[DOI] 10.1186/s43054-021-00082-y PMC 바로가기 [Article Type] Review

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19

420

Published on 2021-10-052022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS,

[키워드] Activation acute respiratory syndrome alteration basophils CD63 CD69 circulating clinical complication clinical feature Clinical features Clinical outcome collected combined use computational modeling convalescent convalescent phase coronavirus correlated COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient COVID-19 patients COVID-19 severity CXCR4 detrimental dysregulated dysregulation eosinophil eosinophil and basophil activation Evidence expression flow cytometry granulocyte Granulocytic heterogeneity high-dimensional flow cytometry Hospitalization identify immature immune immune response immunotype indicate inflammatory markers inflammatory state innate immune response involved laboratory measurement longitudinal analysis Migration Multiorgan dysfunction neutrophil neutrophil heterogeneity Neutrophils pathophysiologic Patient Peripheral blood phenotypic phenotypic data predict predicted Predictive profiles Protein provide receptor Respiratory function reveal SARS-COV-2 infection selected severity of COVID-19 Significance significantly subset the disease viral immune responses virus clearance with COVID-19
[DOI] 10.1073/pnas.2109123118 PMC 바로가기 [Article Type] 420

Increased serum catalytic iron may mediate tissue injury and death in patients with COVID-19

증가 된 혈청 촉매 철분은 Covid-19 환자에서 조직 손상 및 사망을 매개 할 수 있습니다.

Article

Published on 2021-10-042022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 치료기술,

[키워드] 95% CI active form Adult patients adverse outcome adverse outcomes age age and gender Analysis association baseline levels Biomarkers catalytic Clinical diagnosis Composite COVID-19 cross-sectional death determine disease disease severity enrolled examined Factor ferritin ferritin level ferritin levels hepcidin in-hospital mortality Increased Infectious diseases iron iron chelation Iron metabolism joint kidney males mechanical ventilation median age metabolism Molecular biology Molecular medicine occurred outcome parameter Pathogenesis pathophysiologic pathophysiology pathway Patient patients patients hospitalized patients with COVID-19 Previous studies previous study Primary outcome Prognostic markers raising replacement therapy serum significantly therapy tissue injury Transferrin Ventilation was done
[DOI] 10.1038/s41598-021-99142-x PMC 바로가기 [Article Type] Article

Cerebrospinal fluid cytokine, chemokine, and SARS-CoV-2 antibody profiles in children with neuropsychiatric symptoms associated with COVID-19

Research article

Published on 2021-10-012022-10-05
Journal: Multiple sclerosis and related disorders [Category] SARS, 바이오마커,

[키워드] analyzed antibody Biomarker Case series cerebrospinal fluid chemokine chemokines children children with COVID-19 clinical clinical manifestation Control controls coronavirus correlated COVID-19 CSF cytokine Cytokines described discharge electrochemiluminescence assay elevated Encephalopathy FIVE full-length High-dose IFN-γ IL-1β IL-2 IL-8 Immunotherapy Inflammatory intravenous laboratory-confirmed mechanism MIG MIP-1β MIS-C N-terminal domain Neuroinflammation Neuropsychiatric occur one patient outcome pathophysiologic Patient pediatric pediatric COVID-19 Pediatric patient pro-inflammatory profile Psychiatric Psychiatric symptoms Receptor binding domain required Result retrospective SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection Seizures significantly steroid Steroids student Symptom Symptoms syndrome t-test tested TNF-α Tocilizumab Treatment with COVID-19
[DOI] 10.1016/j.msard.2021.103169 [Article Type] Research article

MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients

Research article

Published on 2021-10-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 바이오마커,

[키워드] ACE2angiotensin-converting enzyme 2 ACEangiotensin-converting enzyme ACEiangiotensin-converting enzyme inhibitors Acute kidney injury affected age AKIAcute Kidney Injury Analysis Angangiotensin angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitors ARBangiotensin receptor blockers association BMI Clinical outcome Comorbidity Control Coronavirus disease 2019 corticosteroid treatment COVID-19 COVID-19 group COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19coronavirus disease 2019 diabetes Hospital admission Hospitalization hypertension hypertensive COVID-19 patient ICU In-hospital death inhibitors of the renin-angiotensin system iRAAsinhibitors of the renin-angiotensin system lung Manifestations Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 metalloproteinase metalloproteinases MMP-2Matrix Metalloproteinase 2 MMP-9Matrix Metalloproteinase 9 MMPsmetalloproteinases Mortality not affected obesity pathophysiologic Patient patients with COVID-19 plasma predicted predictor prognostic RASRenin-angiotensin system renin-angiotensin system respiratory risk SAPS3Simplified Acute Physiology Score III SARS-CoV-2severe acute respiratory syndrome coronavirus 2 sequential organ failure assessment score severe acute respiratory syndrome coronavirus 2 severe COVID-19 Sex Simplified Acute Physiology Score III SOFA score SOFAsequential organ failure assessment score study group survival Symptom treated were measured
[DOI] 10.1016/j.biopha.2021.112067 [Article Type] Research article

Neutralizing type-I interferon autoantibodies are associated with delayed viral clearance and intensive care unit admission in patients with COVID-19

I형 인터페론 자가항체 중화는 코로나19 환자의 바이러스 제거 지연 및 중환자실 입원과 관련이 있습니다

Article

Published on 2021-10-012022-09-11
Journal: Immunology and Cell Biology [Category] MERS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus 2 Admission affected Antiviral antiviral activity autoantibody circulating Clinical outcome clinical outcomes contribute coronavirus coronavirus disease COVID-19 COVID-19 pneumonia Critical Defense deficiency Evidence Hospitalized hospitals Host IFN IFN signaling IFNs Illness severity immune Immunological deficiency syndromes impairing increased risk individuals infected individuals Infectious diseases Innate immunity intensive care intensive care unit interferon interferons interferons (IFNs Italian mechanism mediators Neutralizing outcome pathophysiologic Patient patients with COVID-19 Pneumonia respiratory severe acute respiratory syndrome Coronavirus severe COVID-19 Support survival translational Translational immunology Viral viral clearance viral infection
[DOI] 10.1111/imcb.12495 PMC 바로가기 [Article Type] Article