Cardiovascular disturbances in COVID-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by SARS-CoV-2Review Published on 2022-03-092022-10-27 Journal: BMC Public Health [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] angiotensin-converting enzyme-2 Asymptomatic binding cardiovascular cardiovascular damage cardiovascular disorder Cardiovascular disorders cardiovascular morbidity cardiovascular system cause clinical evidence coronavirus Coronavirus-2 COVID-19 Critical Cytokine storm disease disease manifestation Evolution expresse Follow-up imaging Infection intensive care Mild morbidity and mortality myocarditis outcome pathophysiology patients Perturbation phenotype Phenotypes Positron emission tomography receptor respiratory virus SARS-CoV-2 SARS-COV-2 infection severe disease significantly Symptomatic patients systemic Takotsubo cardiomyopathy the disease Thromboembolism Treatment virus [DOI] 10.1186/s12872-022-02534-8 PMC 바로가기 [Article Type] Review
Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entryImatinib 및 methazolamide는 ACE2 효소 활성을 높이고 바이러스 진입을 억제하여 COVID-19 유발 대사 합병증을 개선합니다Article Published on 2022-03-012022-09-11 Journal: Cell Metabolism [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, [키워드] ACE2 ACE2 binding ACE2 pathway Activation cardiovascular system Complication Compound coronavirus disease Coronavirus disease 2019 COVID-19 database disease enzymatic activator enzymatic activity harpagoside identify Imatinib impairment IMPROVE in vivo inhibited inhibiting insulin key factor kidney liver mechanism metabolic complication methazolamide methazolamide. multiple tissue multiple tissues Perturbation SARS-CoV-2 severe metabolic Spike protein systemic disease treat Treatment viral entry Virtual screening virus infection [DOI] 10.1016/j.cmet.2022.01.008 PMC 바로가기 [Article Type] Article
COVID-19-specific metabolic imprint yields insights into multiorgan system perturbationsCOVID-19 관련 대사 흔적은 다기관 시스템 섭동에 대한 통찰력을 제공합니다Article Published on 2022-03-012022-09-11 Journal: European Journal of Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Affect aligned alteration capture cellular circulating metabolome Comorbidities Comorbidity confounding factor Corona Coronavirus-2 COVID-19 COVID-19 severity damage defined disease driven by hospitalized COVID-19 patient immune activation immunological immunology indicated Inflammation integration metabolite metabolome metabolomics molecular multi Multi-omics Multiorgan multiple pathway multiple pathways network Neuroinflammation neurological organ damage organ systems performed Perturbation perturbations proteomic question recent resource respiratory SARS-CoV-2 Seroconversion severe acute respiratory syndrome Coronavirus severe COVID-19 patients severity switch trajectory unique [DOI] 10.1002/eji.202149626 PMC 바로가기 [Article Type] Article
Allosteric Determinants of the SARS-CoV-2 Spike Protein Binding with Nanobodies: Examining Mechanisms of Mutational Escape and Sensitivity of the Omicron VariantArticle Published on 2022-02-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), SARS, [키워드] ACE2 host receptor ACE2-binding site allosteric interactions Alter Analysis binding binding affinity binding epitope binding free energy biochemical Combination complex complexes computational analysis dependent on determinant detrimental escape escape mutant examined Examining functional generate hotspot induce less mechanism modulation molecular dynamics Molecular simulation Mutation mutational sensitivity nanobodies nanobody network analysis neutralization neutralizing capacity omicron performed Perturbation plasticity Regulatory residues Resilience SARS-CoV-2 spike protein signal transmission spike Spike protein spike trimer supported the SARS-CoV-2 the SARS-CoV-2 virus variant [DOI] 10.3390/ijms23042172 PMC 바로가기 [Article Type] Article
Glycosylation and Serological Reactivity of an Expression-enhanced SARS-CoV-2 Viral Spike Mimetic발현이 강화된 SARS-CoV-2 바이러스 스파이크 모방체의 당화 및 혈청학적 반응성Research Article Published on 2022-01-302022-09-10 Journal: Journal of Molecular Biology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Abstract analysed Analysis antibody antigenic capture changes in clinical sample clinical samples COVID-19 patient COVID-19 patients detect discrepancies exhibit expression Extensive feature globe glycoprotein Glycoproteins glycosylation HexaPro IgA IgG IgM response IgM responses impacted include infected individual infected individuals Mimetic N-linked glycan N-linked glycans N-linked glycosylation observation performed Perturbation prefusion conformation proline proline substitution Protein protein structure reactivity S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 spike sera serological serological activity serological assessment serological studies serology spike stability Substitution substitutions trimeric spike Variation variations Viral viral glycoprotein viral glycoproteins virus viruses [DOI] 10.1016/j.jmb.2021.167332 PMC 바로가기 [Article Type] Research Article
Insights on the mutational landscape of the SARS-CoV-2 Omicron variant receptor-binding domainSARS-CoV-2 Omicron 변이 수용체 결합 도메인의 돌연변이 환경에 대한 통찰력Article Published on 2022-01-242022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Amino acid analyses antibody antibody epitopes antibody escape antigenic antigenic drift breadth conformational Disruption domain driving epistasis epitope epitope-paratope Epitopes Evidence feature initial insight Interaction interface Mutation network analysis neutralization omicron Omicron variant Perturbation perturbations Point mutation predicted RBD RBD interface stability RBD mutations resulting SARS-CoV-2 sequence stability the RBD the SARS-CoV-2 therapeutic therapeutic antibodies Transmissibility variant variant of concern [DOI] 10.1016/j.xcrm.2022.100527 PMC 바로가기 [Article Type] Article
Janus Kinase Signaling Pathway and Its Role in COVID-19 Inflammatory, Vascular, and Thrombotic ManifestationsReview Published on 2022-01-172022-10-31 Journal: Cells [Category] COVID-19, [키워드] activated addition catastrophic Coagulation system Coagulopathy concerning contribute COVID-19 COVID-19 patients Cytokine storm disease dysregulation endothelial cells Infection Inflammation Jak JAK inhibitor janus Janus kinase Janus kinase signaling kinase manifestation mechanism Mortality organ dysfunction Organ failure organs patients Perturbation phenotype Platelets presenting public health crisis role SARS-CoV-2 SARS-COV-2 infection Signaling the disease therapeutic these cell thrombosis thrombotic triggering [DOI] 10.3390/cells11020306 PMC 바로가기 [Article Type] Review
Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infectionSARS-COV-2 감염 후 몇 달 후 말초 면역계의 장기 섭동Research Article Published on 2022-01-142022-09-01 Journal: BMC Medicine [Category] SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Analysis anti-RBD Anti-RBD IgG Antibody responses Blood cellular controls convalescent convalescent individual convalescent individuals Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID COVID-19 Critical CXCR3 deep disease severity Effects explain follicular Gene Expression healthy healthy controls IgG responses immune population immune response immune responses immune system Immunity Immunophenotyping in some increasingly individuals Infection Long COVID Mild moderate molecular Monocytes Neutrophils NK cells pandemic PASC Patient persistence Perturbation plethora Post COVID-19 condition Post-acute sequelae of COVID-19 (PASC) Post-infection referred to regulatory T cells reported Research respiratory respiratory virus response responsible Result RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference significant differences supplementary material Symptom syndrome T cell T cells T helper transcriptional transcriptional level Transcriptome uninfected [DOI] 10.1186/s12916-021-02228-6 PMC 바로가기 [Article Type] Research Article
COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives관절 노화 및 골관절염의 COVID-19: 현황 및 전망Review Published on 2022-01-102022-09-12 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] accelerated adipose Adipose tissue Ageing aging aging process analyzed angiotensin angiotensin-converting enzyme 2 calcium Characteristics Connective tissues contribute COVID-19 COVID-19 patients current deficiency dysfunction Effect endothelial evaluated explain exploration expression hypovitaminosis Hypovitaminosis D Inflammation joint joint and muscle pain knowledge long-COVID long-lasting molecular morbidity muscle pain Musculoskeletal musculoskeletal aging musculoskeletal symptom neuronal function new treatment strategy Osteoarthritis Pain Perturbation perturbations phenotype primary site recent Renin renin-angiotensin system road SARS-CoV-2 Society status Symptom tissue Topic Treatment [DOI] 10.3390/ijms23020720 PMC 바로가기 [Article Type] Review
Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistaminesObservational Study Published on 2022-01-012022-10-05 Journal: Journal of investigative medicine : the official p [Category] SARS, 임상, [키워드] acute illness addressed alteration anaphylaxis Anecdotal antagonist Asymptomatic CD28 CD4+ CD8+ Cell cells central memory characteristic characterized Clinical improvement clinical response COVID COVID-19 diagnostic diagnostic tests effector memory etiology expression Hospitalization HRA immunologic tests individual Long long-COVID mechanism Mild participant Patient Perturbation programmed cell death Protein quantified question questionnaire receptor reduced regulated reported required routine SARS-CoV-2 SARS-COV-2 infection Symptom symptomatic Symptoms T cell T cell subset T cells [DOI] 10.1136/jim-2021-002051 PMC 바로가기 [Article Type] Observational Study