Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural ModelsResearch Article Published on 2021-06-232022-10-30 Journal: mSphere [Category] COVID-19, MERS, SARS, [키워드] accumulating ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 associated immune response Brain cell tropism cell type cells Central nervous system cerebrospinal fluid CNS contribute coronavirus COVID-19 COVID-19 patients Culture cultures disease Evidence expression H5N1 H5N1 influenza A H5N1 virus highly pathogenic hiPSC neurons Human Hypothesis IL-8 induced infect Infection influenza A virus Influenza virus interferon Invasion investigated Kinetics local immune response Model Neural Neurological complication Neurological complications Neuron neurons neurotropic neurotropism NPR1 olfactory Pathogenesis pluripotent stem cell protease replicated replication kinetics response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication serine 2 Spread STEM subsequent Support TMPRSS2 transmembrane triggered triggering tropism type III interferon variety virus virus replication virus spread [DOI] 10.1128/mSphere.00270-21 PMC 바로가기 [Article Type] Research Article
Transgene Delivery to Human Induced Pluripotent Stem Cells Using NanoparticlesReview Published on 2021-04-062022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 2019 coronavirus disease Affect approach biodegradability Cell COVID-19 COVID-19 vaccines Culture cytotoxicity delivery demonstrated diagnostics directional distal Efficiency example facilitate functional generate Genetic Human human induced pluripotent stem cells human induced pluripotent stem cells-derived cardiomyocytes immune responses in vivo induced lack Magnetic nanoparticles Modification nanomedicine nanoparticle Nanoparticles Nanotechnology offer pluripotent stem cell powerful tool Precision provided regenerative robust SARS-CoV-2 SARS-CoV-2 vaccine somatic cell STEM these cell transfection transgene Vaccine [DOI] 10.3390/ph14040334 PMC 바로가기 [Article Type] Review
iPSC screening for drug repurposing identifies anti‐RNA virus agents modulating host cell susceptibilityResearch Article Published on 2021-04-062022-10-31 Journal: FEBS Open Bio [Category] COVID-19, SARS, [키워드] antiviral activity Antiviral effect blocked cells Combination Compound conducted demonstrated drug drugs Ebola virus Efficacy estrogen receptor evaluated exhibited genomic RNA host cell host cells Huh7 cell Human Human immune system human iPSC identify Infection infections inhibitory effect local outbreak modulate modulating mutated Mutation Pandemics Paramyxoviridae pathogenic pioglitazone pluripotent stem cell PPARγ PPARγ public health Repurposed drug RNA virus RNA viruses SARS‐CoV‐2 SARS‐CoV‐2 Sendai virus SERMs susceptibility synergistic therapeutic therapeutic potential threat Vaccine Vero E6 cell VERO E6 cells Viral diseases virus viruses while [DOI] 10.1002/2211-5463.13153 PMC 바로가기 [Article Type] Research Article
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids폐 및 결장 오르가노이드를 이용한 SARS-CoV-2 억제제 식별Article Published on 2021-01-012022-09-11 Journal: Nature [Category] MERS, SARS, 바이오마커, 신약개발, 진단, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar approved Cell cell types cells chemokine chemokines colonic complementary coronavirus COVID-19 COVID-19 therapeutics Disease model disease models drug Drug administration Drug screening enterocytes Entry inhibitor entry inhibitors Express facilitate FDA food hPSC-derived colonic organoid human disease identification identify Imatinib infect inhibited inhibitor lung Manifestations mycophenolic acid Organoid outcome Patient patients with COVID-19 performed pluripotent stem cell quinacrine respiratory respiratory tract robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus significantly stem cells These data US Food and Drug Administration valuable resource [DOI] 10.1038/s41586-020-2901-9 PMC 바로가기 [Article Type] Article
Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell-Derived Intestinal Organoids인간 만능 줄기 세포 유래 장 오르가노이드에서 SARS-CoV-2 복제의 약물 억제Article Published on 2021-01-012022-09-12 Journal: Cellular and molecular gastroenterology and hepato [Category] SARS, 진단, [키워드] ACE2 expression Concentration COVID-19 COVID-19 pandemic COVID-19 patient descending Deterioration diarrhea Disease model dissect drug Drug testing Efficiency expression Famotidine gastrointestinal infections Gastrointestinal symptom gastrointestinal tract Goblet cell Gut Health highest Human identify infected with SARS-CoV-2 inhibited inhibition intestinal intestinal organoid Intestinal Organoids intestine investigated mild symptoms mimicking morphology nausea Organoid Patient pluripotent stem cell Pneumonia priming protease TMPRSS2 receptor ACE2 Remdesivir rescued risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 spike protein severity Spread STEM Symptom Treatment viral entry viral spread while [DOI] 10.1016/j.jcmgh.2020.11.003 PMC 바로가기 [Article Type] Article
Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes인간 다능성 줄기세포 유래 심근세포에서 SARS-CoV-2 감염에 대한 렘데시비르의 항바이러스 활성 및 안전성Article Published on 2020-12-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral activity authorization automaticity Cardiotoxicity caused close monitoring Concentration conditions coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 drug candidate drugs Emergency Emergency use authorization evaluated exhibited global public health Health crisis Human Human cardiomyocytes indicated individual information medication moderate multielectrode peak plasma concentration pluripotent stem cell pluripotent stem cells potential risk QT interval QT prolongation Remdesivir respiratory risk safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus stem cells suggested therapeutic option These cells Vero E6 VERO E6 cells [DOI] 10.1016/j.antiviral.2020.104955 PMC 바로가기 [Article Type] Article
Molecular investigation of adequate sources of mesenchymal stem cells for cell therapy of COVID‐19‐associated organ failureCOVID-19 관련 장기부전의 세포치료제를 위한 중간엽 줄기세포의 적절한 공급원에 대한 분자 조사Enabling Technologies for Cell‐based Clinical Translation Published on 2020-11-252022-09-10 Journal: Stem cells translational medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 adipose Adipose tissue adult human bone marrow Analysis Bone marrow Cell Cell therapy COVID‐19 COVID‐19 infection cultures determine embryonic embryonic stem cell embryonic stem cells Express expressed expression facilitate induced pluripotent stem cells infections less lowest Lymphocytes Mesenchymal stem cells MSC MSCs Organ failure outbreak passage Patient pluripotent stem cell receptor ACE2 stem cell Stem cell therapy stem cells suggested target target cell target cells therapy tissue Transcriptome transcriptome analysis transfused umbilical virus virus entry [DOI] 10.1002/sctm.20-0189 PMC 바로가기 [Article Type] Enabling Technologies for Cell‐based Clinical Translation
Human induced pluripotent stem cells as a tool for disease modeling and drug screening for COVID-19Articles Published on 2020-11-162022-10-31 Journal: Genetics and Molecular Biology [Category] COVID-19, [키워드] affected Brazil cell type Compound contribute COVID-19 COVID-19 pandemic disease Drug screening generate Host Human human pluripotent stem cells immortalized cell line in vitro in vivo Interaction performed phenotypic platform pluripotent stem cell Prevent Research resulting SARS-CoV-2 Screening Stem cell differentiation the disease Therapeutic strategies tissue viral infection virus [DOI] 10.1590/1678-4685-GMB-2020-0198 PMC 바로가기 [Article Type] Articles
Diesel Particulate Matter 2.5 Induces Epithelial-to-Mesenchymal Transition and Upregulation of SARS-CoV-2 Receptor during Human Pluripotent Stem Cell-Derived Alveolar Organoid DevelopmentArticle Published on 2020-11-132022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] accompanied Activation acute respiratory syndrome adverse effect AEC Affect alveolar alveolar organoid angiotensin-converting enzyme 2 Cell childhood clade cofactor coronavirus demonstrated development developmental dPM2.5 EMT epithelial Evidence explain exposure to expression Extracellular fibrosis had no Human human pluripotent stem cells in vitro incidence infancy Inflammation investigated lack lung Lung function matter mechanism multicellular nicotinamide adenine dinucleotide Organoid Particulate phosphate platform pluripotent stem cell prenatal promoted protease Protein provided pulmonary disease receptor reduced Research SARS-CoV-2 serine 2 Signaling significantly STEM susceptibility target cells Toxicity toxin transition transmembrane treated Treatment unique upregulated upregulation virus [DOI] 10.3390/ijerph17228410 PMC 바로가기 [Article Type] Article
Organoid based personalized medicine: from bench to bedsideReview Published on 2020-11-022022-10-31 Journal: Cell Regeneration [Category] COVID-19, [키워드] accumulating addition application Biobanks Cancer CRISPR-Cas9 disease modeling Diseases Evidence fibrosis Genetic in vitro in vivo malignant diseases Organoid organoids organs Personalized medicine phenotypic pluripotent stem cell regenerative Research stem cell stem cells tissues translational [DOI] 10.1186/s13619-020-00059-z PMC 바로가기 [Article Type] Review