Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units확장된 COVID-19 중환자실에서 2차 감염 치료 및 병원 전파 감지를 개선하기 위한 호흡기 메타유전체학의 잠재력 평가Research Published on 2021-11-172022-09-10 Journal: Genome Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] 95% CI absence added Antibiotic resistance Antibiotics approach Aspergillus fumigatus Bacterial carried clinical clinical assessment COVID-19 COVID-19 pandemic Critical care Culture detect evaluated Evaluating expansion Genome genomic Genomic surveillance ICU ICUs IMPROVE increased risk Infection infection control infections initial intensive care unit intubated patient Laboratory MDR modify Nanopore nanopore sequencing nosocomial Nosocomial transmission outbreak pathogen pathogen detection Pathogens Patient pneumoniae positive presence or absence provide quantitative PCR reported Research respiratory respiratory sample Respiratory samples Result SARS-CoV-2 pandemic Secondary infection Sequencing sequencing data Seven supplementary material Surveillance translated Transmission Treatment [DOI] 10.1186/s13073-021-00991-y PMC 바로가기 [Article Type] Research
Meropenem-Resistant Pandoraea Pneumonia in a Critically Ill Patient With COVID-19Infectious Disease Published on 2021-11-122022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 16s ribosomal dna sequencing acute respiratory distress antibiotic Antibiotic resistance ARDS Bacterial carbapenem carbapenems Care Co-infection COVID-19 Critical care Critically ill Culture drug resistance fibrosis Ill IMPROVE In-vitro increasingly Infection initiated Laboratory testing mechanical ventilation multi-drug resistant multi-organ failure P. aeruginosa pandoraea species Patient Pneumonia pneumoniae proinflammatory reduce regimen reported respiratory specimen respiratory viruses rising SARS-COV-2 infection secondary bacterial pneumonia sensitivity sputum culture subsequent susceptibility syndrome transitioned Treatment VAP Ventilator associated pneumonia with COVID-19 [DOI] 10.7759/cureus.19498 PMC 바로가기 [Article Type] Infectious Disease
Fecal Carriage and Molecular Characterization of Carbapenemase-Producing Enterobacterales in the Pediatric Population in QatarResearch Article Published on 2021-11-102022-10-30 Journal: Microbiology Spectrum [Category] Coronavirus, MERS, SARS, [키워드] Klebsiella pneumoniae Arabian Peninsula Asymptomatic carrier Carbapenemase Care carriage carrier Characteristics characterization characterized children Comorbidity coronavirus disease country CPE dominant E. coli Endemic enzyme Escherichia coli exhibited expressed fecal Genes genetic diversity Genotype Health hospital implementation incidence International introduced isolate Klebsiella pneumoniae knowledge Local molecular Multiple NDM OXA-48 Patient patients pediatric pneumoniae Population produced rectal sequence Sequencing strain swab sample Travel variant was used whole-genome sequencing [DOI] 10.1128/Spectrum.01122-21 PMC 바로가기 [Article Type] Research Article
Bacterial Epidemiology and Antimicrobial Resistance Profiles in Children Reported by the ISPED Program in China, 2016 to 2020중국 ISPED 프로그램에서 보고된 2016년부터 2020년까지 아동의 세균 역학 및 항균제 내성 프로필Research Article Published on 2021-11-032022-10-30 Journal: Microbiology Spectrum [Category] Coronavirus, MERS, SARS, 폐렴구균 감염증, [키워드] Acinetobacter age analyzed antimicrobial antimicrobial resistance antimicrobial susceptibility automated Bacteria Bacterial Care carried children China Chinese clinical collected comparable coronavirus disease COVID-19 described distribution drug resistance effective Enterobacteriaceae Epidemiology Escherichia coli H. influenzae Haemophilus influenzae hospital humans Impact increasingly Infection Infectious Disease Surveillance of Pediatrics (ISPED) Interpretation isolate Klebsiella pneumoniae MONITOR Moraxella catarrhalis morbidity and mortality MRSA multidrug-resistant Multidrug-resistant organisms Neonates opposite organism P. aeruginosa pandemic pathogen Patient Pediatric patients pediatrics pneumoniae predominant Prevalence producing profile Program proportion Pseudomonas aeruginosa reduction reduction in required resistance respiratory tract sample respiratory tract samples Standard Staphylococcus aureus Staphylococcus epidermidis strain Strains Streptococcus pneumoniae Streptococcus pyogene Surveillance therapy threat treat [DOI] 10.1128/Spectrum.00283-21 PMC 바로가기 [Article Type] Research Article
Case Report: Interferon- γ Rescues Monocytic Human Leukocyte Antigen Receptor (mHLA-DR) Function in a COVID-19 Patient With ARDS and Superinfection With Multiple MDR 4MRGN Bacterial StrainsImmunology Published on 2021-11-012022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] Acinetobacter acute respiratory distress adaptive adaptive immune system antibiotic Antigen Antigen presentation ARDS Bacterial bacterial pathogen bloodstream boost carbapenem CD14+ monocyte Cefiderocol Cell Citrobacter complication of COVID-19 complications COVID-19 deficiency described discharge ECMO expressed expression expression level extracorporeal membrane oxygenation FACS analysis function HLA-DR hospital Human identify IFNγ immune Immune cell immune response Immune status immune system Immunity immunological synapse Immunosuppression indicated Infection interferon invasive isolate Klebsiella pneumoniae leukocyte lung MDR mHLA-DR monocyte multidrug-resistant Multiple outcomes Patient Pneumonia pneumoniae positive present antigen profile Pseudomonas aeruginosa rapid increase receptor regimen report rescue risk factor Secondary infection Sepsis septicemia severe immunosuppression severe pneumonia strain suggested superinfection Support suppressed syndrome the patient therapeutic therapy [DOI] 10.3389/fimmu.2021.753849 PMC 바로가기 [Article Type] Immunology
Comparison of 11 respiratory pathogens among hospitalized children before and during the COVID-19 epidemic in Shenzhen, China중국 심천의 Covid-19 전염병 전과 중에 입원 어린이들 사이에서 11 개의 호흡기 병원체의 비교Comparative Study Published on 2021-10-092022-09-10 Journal: Virology Journal [Category] MERS, SARS, 치료기술, [키워드] Acute respiratory infection acute respiratory infections Adenovirus analyzed children China circulation collected COVID-19 COVID-19 epidemic detection rate enrolled Epidemic Hospitalized Human human metapneumovirus human parainfluenza virus Human respiratory syncytial virus Human rhinovirus Influenza influenza A measure Multiplex PCR Mycoplasma pneumoniae nasopharyngeal swabs outbreak parainfluenza virus pathogen Pathogens Patient pneumoniae Prevalence preventive measure preventive measures remains uncertain respiratory respiratory pathogen Respiratory pathogens respiratory syncytial virus respiratory tract infection Result rhinovirus SARS-CoV-2 Seasonal influenza Shenzhen significantly lower Swab virus [DOI] 10.1186/s12985-021-01669-y PMC 바로가기 [Article Type] Comparative Study
Bacterial and fungal ventilator associated pneumonia in critically ill COVID-19 patients during the second wave2차 유행 동안 중환자 COVID-19 환자의 박테리아 및 곰팡이 인공 호흡기 관련 폐렴Article Published on 2021-10-012022-09-11 Journal: Journal of infection and public health [Category] SARS, 치료기술, [키워드] 95% CI 95% confidence interval Acinetobacter admitted to ICU antimicrobial antimicrobial resistance antimicrobial susceptibility Aspergillus Bacteria Bacterial Bacterial infections Candida caused Chest collected coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient Critical Critically ill critically ill COVID-19 patients Culture diabetes Diabetes Mellitus diagnosed disease element followed by fungal fungi Hypothyroidism ICUs identify intensive care unit intensive care units isolate isolates Klebsiella pneumoniae MDR mechanical ventilation Mucor multi outcomes pandemic Patient PDR Pneumonia pneumoniae positive respiratory Respiratory samples risk factor Risk factors SARS-CoV2 second wave specimen specimens subsequent susceptibility Tocilizumab Treatment VAP ventilator Ventilator associated pneumonia [DOI] 10.1016/j.jiph.2021.08.003 PMC 바로가기 [Article Type] Article
Clinical profile of bloodstream infections in COVID-19 patients: a retrospective cohort studyResearch Published on 2021-09-082022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] Acinetobacter Acinetobacter baumannii Admission Analysis Antibiotics antimicrobial resistance bloodstream bloodstream infection BSI BSIs carbapenem Care clinical Clinical outcome clinician Compliance conducted Coronavirus disease 2019 COVID COVID-19 COVID-19 patients Critically ill demographic data Enterococcus Gram-negative bacteria groups hospital ICU IMPROVE incidence India Infection infection control intensive care Klebsiella pneumoniae leukocyte majority mechanical ventilation morbidity and mortality Occurrence organism outcome pathogen Patient Pneumonia pneumoniae polymerase chain presence of comorbidity Prevalence proportion raised reduce Result retrospective cohort study Retrospective study RT-PCR searched severe COVID-19 patient significantly [DOI] 10.1186/s12879-021-06647-x PMC 바로가기 [Article Type] Research
Development and clinical evaluation of a rapid antibody lateral flow assay for the diagnosis of SARS-CoV-2 infectionSARS-COV-2 감염의 진단을위한 빠른 항체 측면 흐름 분석의 발달 및 임상 평가Research Article Published on 2021-08-232022-09-01 Journal: BMC Infectious Diseases [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analytical sensitivity analyzed antibody Antibody test can be used caused clinic clinical Clinical application value clinical evaluation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients cross-reactivity development Diagnosis diagnosis of SARS-CoV-2 disease course Escherichia coli evaluate expressed false-negative false-negative results Fever fragment of Health IgM antibody Infection Infectious disease lateral flow lateral flow assay limitations measure Mycoplasma pneumoniae N protein Novel coronavirus novel coronavirus disease nuclear Nurse Nurses outbreak Pathogens Patient pneumoniae positive rate professional Protein Pulmonary infection purified rapid antibody test rapid antibody test kit real-time PCR Kit Recombinant S1 protein respiratory Respiratory pathogens respiratory tract infection Result RT-PCR SARS-CoV-2 SARS-CoV-2 antibody test SARS-CoV-2 diagnosis SARS-COV-2 infection serum severe acute respiratory syndrome Coronavirus significantly specificity Spike protein Spread supplementary material were expressed [DOI] 10.1186/s12879-021-06568-9 PMC 바로가기 [Article Type] Research Article
Trends of Multidrug-Resistant Pathogens, Difficult to Treat Bloodstream Infections, and Antimicrobial Consumption at a Tertiary Care Center in Lebanon from 2015–2020: COVID-19 AftermathArticle Published on 2021-08-212022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] Acinetobacter baumannii and COVID-19 analyzed antimicrobial antimicrobial resistance antimicrobial stewardship in COVID-19 Bacteremia Blood BSI calculated carbapenem Care center Consumption Corynebacterium COVID-19 CRE Culture cultures Difficult E. coli Enterobacteriaceae Epidemics excluded exclusion criteria Infection prevention Infectious disease isolate isolates Isolation material MDR and COVID-19 organism P -value P. aeruginosa pandemic Patient pneumoniae Result Saint George significant decrease Staphylococcus Staphylococcus epidermidis susceptibility Tertiary the SARS-CoV-2 Total trend unique university VRE and COVID-19 worsened [DOI] 10.3390/antibiotics10081016 PMC 바로가기 [Article Type] Article