polyclonal antibodies – Page 3 – Communicable Diseases Research

One-Step, Wash-free, Nanoparticle Clustering-Based Magnetic Particle Spectroscopy Bioassay Method for Detection of SARS-CoV-2 Spike and Nucleocapsid Proteins in the Liquid Phase

액상에서 SARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질 검출을 위한 원스텝, 무세척, 나노입자 클러스터링 기반 자기 입자 분광법 생물검정 방법

Article

Published on 2021-09-222022-09-11
Journal: ACS applied materials & interfaces [Category] SARS, 치료기술, 치료법, 치료제,

A Competitive Hemagglutination Inhibition Assay for Dissecting Functional Antibody Activity against Influenza Virus

Article

Published on 2021-09-152023-06-14
Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자,

[키워드] antibody HAI assay hemagglutination inhibition assay (HAI) hemagglutinin influenza vaccine Influenza virus monoclonal antibodies (mAbs) polyclonal antibodies serum
[DOI] 10.1128/JVI.02379-20 PMC 바로가기

Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection

mRNA-1273 백신 접종에 의해 유도된 항체는 SARS-CoV-2 감염에서보다 수용체 결합 도메인에 더 광범위하게 결합합니다

Research Article

Published on 2021-06-302022-09-10
Journal: Science Translational Medicine [Category] MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity affected antibodies antibody antibody epitope antibody epitopes antibody immunity Antibody Response Antibody responses antigenic evolution binding breadth characterized convalescent sera coronavirus deep demonstrated dose elicited epitope Epitopes erosion greater human antibody response Immunity immunization Infection less Moderna mRNA-1273 vaccine mRNA mRNA-1273 mRNA-1273 COVID-19 vaccine Mutation natural infection neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody polyclonal antibodies polyclonal antibody raised RBD RBD mutation RBD-binding antibody Receptor binding domain Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 spike protein sera severe acute respiratory syndrome Coronavirus specificity Spike protein susceptibility the antibody response the RBD the receptor-binding domain the SARS-CoV-2 vaccination Vaccine variant variants Viral viral evolution viral mutation Viral mutations
[DOI] 10.1126/scitranslmed.abi9915 PMC 바로가기 [Article Type] Research Article

High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2

SARS-CoV-2에 대한 돼지 당-인간화 다클론항체의 높은 중화 효능

Article

Published on 2021-06-012022-09-12
Journal: European Journal of Immunology [Category] MERS, SARS, 진단,

[키워드] accumulating acute respiratory syndrome allergy animal anti-SARS-CoV-2 Antibody Response Antibody-dependent enhancement assays binding Concentration convalescent plasma coronavirus coronavirus disease COVID-19 cytidine cytopathic Dilution domain Epitopes exacerbated Fc receptors fraction GGTA1 good manufacturing practices heterologous antibody Human human cell hyperimmune response IgG immunized Infection Inflammatory response inhibited Interaction mAbs monoclonal antibody multiple antigen neutralized Neutralizing neutralizing antibody pig polyclonal polyclonal antibodies polyclonal antibody purified Receptor binding domain SARS-CoV-2 serum sickness spike
[DOI] 10.1002/eji.202049072 PMC 바로가기 [Article Type] Article

SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape

SARS-CoV-2 501Y.V2 변이체는 더 높은 감염성은 없지만 면역 탈출은 있습니다

Article

Published on 2021-04-292022-09-11
Journal: Cell [Category] MERS, SARS, 변종, 진단, 치료기술,

[키워드] 501Y.V2 Abstract caused Cell cell type cell types cells convalescent convalescent patient Convalescent patients dominant E484K Efficacy escaped except for exhibit experiment hACE2 higher infectivity Immune escape immunized immunized mice increase in individuals Infectivity inhibitory effect Inhibitory effects K417N lack mACE2 mice monoclonal antibodies monoclonal antibody multiple mutation multiple mutations murine Mutation N501Y N501Y mutation neutralization neutralization ability neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody polyclonal antibodies polyclonal antibody Pseudotyped virus Pseudotyped viruses receptor binding region Receptor-binding domain reduced SARS-CoV-2 sera significantly South Africa Spike protein susceptibility the receptor-binding domain Vaccines variant variant of SARS-CoV-2 variants variants of SARS-CoV-2 Viral viral spike protein viruses
[DOI] 10.1016/j.cell.2021.02.042 PMC 바로가기 [Article Type] Article

Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant

B.1.351 SARS-CoV-2 변이체의 감염 및 백신 유도 항체 결합 및 중화

Article

Published on 2021-04-142022-09-11
Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단,

[키워드] additional spike mutation additional Spike mutations Antibody binding Antibody titer Antibody titers B.1 B.1.351 B.1.351 variant binding antibody convalescent COVID-19 patient D614G deletions domain Efficacy emerging variants exhibited humoral Humoral immunity individual individuals Infection Live virus Moderna Mutation neutralization neutralize Neutralizing antibody titer neutralizing antibody titers polyclonal antibodies polyclonal antibody protective humoral immunity raising Receptor-binding domain reduced reduction in retained SARS-CoV-2 SARS-CoV-2 B.1.351 variant SARS-CoV-2 variant SARS-CoV-2 variants sera spike mutation Spike protein the spike protein vaccinated individual Vaccine vaccine-induced antibodies variant Viral viral neutralization
[DOI] 10.1016/j.chom.2021.03.009 PMC 바로가기 [Article Type] Article

Development and application of therapeutic antibodies against COVID-19

COVID-19에 대한 치료 항체의 개발 및 적용

Review

Published on 2021-04-102022-09-12
Journal: International Journal of Biological Sciences [Category] MERS, SARS, 진단,

[키워드] acute respiratory syndrome antibodies antibody antibody cocktail bamlanivimab caused Clinical stage clinical trial cocktail convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 antibody COVID-19 treatment development drug Emergency use etesevimab FDA food format Genome Health Health crisis Host monoclonal antibodies monoclonal antibody pandemic polyclonal antibodies problem proteome REGN-CoV2 SARS-CoV-2 Severe acute respiratory syndrome target targets therapeutic Therapeutic antibody therapeutic interventions therapy Transcriptome treating COVID-19 Treatment U.S. Food and Drug Administration
[DOI] 10.7150/ijbs.59149 PMC 바로가기 [Article Type] Review

The effect of spike mutations on SARS-CoV-2 neutralization

SARS-CoV-2 중화에 대한 스파이크 돌연변이의 영향

Report

Published on 2021-03-062022-09-11
Journal: Cell Reports [Category] SARS, 변종, 진단,

[키워드] Abstract active against acute respiratory syndrome acute respiratory syndrome coronavirus Alter Amino acid amino acid changes amino acid substitution amino acids antibodies antibody Antibody Response Antibody responses B.1.1.7 B.1.1.7 variant B.1.351 change changes in collected convalescent sera coronavirus Critical decrease Divergence effective Efficacy ENCODE evaluate highlight Immune escape individual Infection less lineages mild illness monoclonal antibody Multiple mutants mutated Mutation mutations neutralization Neutralizing antibodies neutralizing antibody new SARS-CoV-2 P.1 polyclonal antibodies polyclonal antibody potency produced Protective Protein pseudotype Pseudotyped virus Real-time monitoring recognizing reduced respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 pseudotyped virus SARS-CoV-2 spike SARS-CoV-2 variants SARS-CoV-2 virus sensitivity sera serology serum sample serum samples severe acute respiratory syndrome Coronavirus spike mutation Substitution Vaccine vaccine efficacy variant variant spike Variation Viral viral entry
[DOI] 10.1016/j.celrep.2021.108890 PMC 바로가기 [Article Type] Report

Rapid in vitro assays for screening neutralizing antibodies and antivirals against SARS-CoV-2

Article

Published on 2020-10-142022-11-01
Journal: Journal of virological methods [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome antibody Antiviral antiviral activity antivirals can be used China complex Compound coronavirus coronavirus disease Coronavirus-2 CoV COVID-19 COVID-19 disease death described drug effective food global pandemic Health human infection humans identify Impact In vitro assay inhibitors mAb mAbs microneutralization MNA monoclonal antibodies monoclonal antibody neutralization neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Novel coronavirus peroxidase Plaque reduction microneutralization assay polyclonal antibodies Prophylactic Rapid reduce reduction reported responsible SARS-CoV SARS-CoV-2 SARS-COV-2 infection Scientific community staining Standardization Therapeutic treatment United State Vaccine while Wuhan
[DOI] 10.1016/j.jviromet.2020.113995 PMC 바로가기 [Article Type] Article

Immunotherapeutic approaches to curtail COVID-19

Article

Published on 2020-08-212022-10-04
Journal: International immunopharmacology [Category] MERS, SARS, 신약개발,

[키워드] Abstract active immunization acute respiratory syndrome administration antibodies antibody antivirals approach associated immune response convalescent plasma coronavirus Corticosteroids country COVID-19 COVID-19 disease course curtail cytokine Defense disease stage drug Drug repurposing evaluated help Host human clinical trials identify immune evasion immune modulation immune response immune system immunomodulatory drugs Immunotherapy interferon JAK inhibitor jak inhibitors knowledge late stage monoclonal pandemic passive immunization pathogenesis of SARS-CoV-2 patients plasma plasma therapy polyclonal antibodies prevention of COVID-19 response SARS-CoV-2 SARS-CoV-2 pathogenesis severe acute respiratory syndrome coronavirus 2 severely ill patients stages suggested suppresse the cytokine storm the disease the patient therapeutic approaches therapy Vaccine Vaccines virus
[DOI] 10.1016/j.intimp.2020.106924 PMC 바로가기 [Article Type] Article