Progress and Challenges in Targeting the SARS-CoV-2 Papain-like ProteaseSARS-CoV-2 파파인 유사 프로테아제 표적화의 진행 상황 및 과제Review Published on 2022-06-092022-09-11 Journal: Journal of medicinal chemistry [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료제, [키워드] addition Antiviral antiviral drug target approval approved causative agent challenge class cleavage clinic combating COVID-19 pandemic Encouraging highlight Host include inhibitor inhibitors innate immune response knowledge mechanism modulate molnupiravir Nirmatrelvir offer pandemic Papain-like protease pharmacokinetic polymerase polyprotein Progress Protease inhibitor Remdesivir Ritonavir SARS-CoV-2 structure-based design targeting the SARS-CoV-2 U.S. FDA Vaccine variant variants viral infection [DOI] 10.1021/acs.jmedchem.2c00303 PMC 바로가기 [Article Type] Review
Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine재조합 식물 기반 면역증강제 코로나19 백신의 효능 및 안전성Clinical Trial Published on 2022-06-022022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 1:1 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adverse event age Analysis AS03 assigned baseline candidate vaccine caused conducted coronavirus coronavirus disease Coronavirus disease 2019 CoVLP CoVLP+AS03 determine disease dose effective Efficacy Factor FIVE incidence injection intention-to-treat intention-to-treat population Intramuscular injection Local median age Median viral load Medicago Mild moderate occurred participant Participants participated Particle performed Phase 3 Placebo placebo group placebo-controlled trial plant plants polymerase Post hoc analysis prefusion produced Randomized receive recombinant respiratory Safety SARS-CoV-2 sequenced Sequencing seronegative severe acute respiratory syndrome Coronavirus Severe case Spectrum spike glycoprotein symptomatic symptomatic COVID-19 symptomatic infection System systemic adverse event systemic adverse events the median the placebo group the vaccine Trial two group two groups Vaccine vaccine efficacy vaccine group variant variants Viral Viral load viral sample Volunteer [DOI] 10.1056/NEJMoa2201300 PMC 바로가기 [Article Type] Clinical Trial
Opportunities and Challenges in Targeting the Proofreading Activity of SARS-CoV-2 Polymerase ComplexReview Published on 2022-05-032023-07-02 Journal: Molecules [Category] COVID19(2023년), SARS, [키워드] coronavirus ExoN exonuclease inhibitor nsp14 nucleoside polymerase Proofreading SARS-CoV-2 [DOI] 10.3390/molecules27092918 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease OutcomesSARS-CoV-2 점 돌연변이 및 삭제 스펙트럼과 다양한 질병 결과와의 연관성Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid amino acid substitution amino acid substitutions Amplicon amplicons Analysis association average complexity consensus sequence coronavirus COVID-19 COVID-19 pandemic COVID-19 severity Deletion deletions develop diagnostic disease diversity index Effects functional Genetic variant genetic variants Haplotype infected patients isolate isolates location Mild mild COVID-19 symptoms Mild disease Mild symptom mild symptoms moderate moderate or severe disease mutant mutant spectra mutant spectrum Mutation mutations nasopharyngeal Nsp12 nsp12 (polymerase) Patient patients with moderate phenotypic Point Point mutation polymerase Region RNA RNA virus RNA viruses SARS-CoV-2 selective pressures Sequencing severe COVID-19 severe disease severity significantly significantly higher Spain spike three-dimensional structure ultradeep sequencing. viral pathogenesis virus [DOI] 10.1128/spectrum.00221-22 PMC 바로가기 [Article Type] Article
Rational Design of CRISPR/Cas12a-RPA Based One-Pot COVID-19 Detection with Design of Experiments실험 계획을 통한 CRISPR/Cas12a-RPA 기반 One-Pot COVID-19 탐지의 합리적 설계Article Published on 2022-04-152022-09-11 Journal: ACS synthetic biology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accelerate addition amplification applied approach benefit buffer complex component components condition COVID-19 COVID-19 pandemic CRISPR CRISPR/Cas12a critical impact definitive screening design demonstrated design of experiments detection Detection sensitivity diagnostic Diagnostic method diagnostics DNA DNA sequence DoE Effect effective experiment Factor full-length SARS-CoV-2 Genome highlight isothermal molecular Molecular diagnosis N gene one-pot COVID-19 testing optimization polymerase reaction reaction optimization Reactions recombinase polymerase amplification recombinase polymerase amplification (RPA). reverse transcription RNA RNase RNase inhibitor robust RPA RT-qPCR sensitivity significant effect significantly simple statistical variables [DOI] 10.1021/acssynbio.1c00617 PMC 바로가기 [Article Type] Article
Swine H1N1 Influenza Virus Variants with Enhanced Polymerase Activity and HA Stability Promote Airborne Transmission in FerretsArticle Published on 2022-04-132023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] ferret influenza A virus polymerase swine viruses Transmissibility viral fusion protein virus adaptation. [DOI] 10.1128/jvi.00100-22 PMC 바로가기
Combining recombinase polymerase amplification and DNA-templated reaction for SARS-CoV-2 sensing with dual fluorescence and lateral flow assay outputSARS-CoV-2 감지를 위한 재조합 효소 중합효소 증폭 및 DNA 주형 반응을 이중 형광 및 측면 흐름 분석 출력과 결합Article Published on 2022-04-012022-09-11 Journal: Biopolymers [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence acid acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification applied Biotin chain Chain Reaction coronavirus coumarin diagnostic disease detection DNA DNA templated reaction early disease early phase effective exacerbated Isolation lateral flow lateral flow assay magnitude methodology naked eye nucleic acid nucleic acid sensing. pandemic Patient peptide PNA point-of-care polymerase polymerase chain polymerase chain reaction reaction recombinase polymerase amplification RNA sequence RPA SARS-CoV-2 severe acute respiratory syndrome Coronavirus stimulated the SARS-CoV-2 transfer Transmission Vaccines while [DOI] 10.1002/bip.23485 PMC 바로가기 [Article Type] Article
Repurposing of phytomedicine-derived bioactive compounds with promising anti-SARS-CoV-2 potential: Molecular docking, MD simulation and drug-likeness/ADMET studiesResearch article Published on 2022-04-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 신약개발, [키워드] active against anti-SARS-CoV-2 approach binding mode Compound computational method COVID-19 database docking Drug repurposing effective Efficacy Enzymes in silico inhibitor inhibitory effect initial management MD simulation molecular docking molecular dynamics Molecular dynamics simulation MPro notable phytochemicals Phytomedicine PLPro polymerase protease RdRP repurposing SARS-CoV-2 SARS-COV-2 infection screened selected steroid therapeutic target Toxicity [DOI] 10.1016/j.sjbs.2021.12.018 [Article Type] Research article
Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a Research Published on 2022-03-212022-10-05 Journal: Nature biomedical engineering [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome Amplicon amplification cleavage comparable coronavirus CRISPR cycle threshold DNA fluorescent isothermal less motifs nasopharyngeal sample Nasopharyngeal samples nucleic acid point-of-care polymerase protospacer adjacent motif quantitative real-time PCR Rapid reporter reverse transcription RNA RNA extraction SARS-CoV-2 SARS-CoV-2 RNA sensitive assay sensitivity specificity substrates [DOI] 10.1038/s41551-022-00861-x [Article Type] Research
Potential Cardiotoxic Effects of Remdesivir on Cardiovascular System: A Literature Review심혈관계에 대한 렘데시비르의 잠재적인 심장독성 효과: 문헌 검토Review Published on 2022-03-012022-09-11 Journal: Cardiovascular toxicology [Category] 치료제, [키워드] Abnormalities action potential adenosine amplitude Atrial fibrillation authorization binding bradycardia Cardiac arrest cardiotoxic effects Cardiotoxicity cardiovascular cardiovascular diseases Cell Chloroquine Complete Corona Corona virus COVID-19 COVID-19 disease cytotoxic effect disease dose-dependent manner Effect Effects Emergency Emergency use authorization followed by Hypotension induce inhibit Intravenous remdesivir literature metabolite mitochondrial mitochondrial RNA nucleotide nucleotide prodrug occur pandemic Patient polymerase Potential prolonged QT interval Prospective clinical trial QTC prolongation refractoriness Remdesivir remdesivir. review safety profile significantly sinus bradycardia Spread Treatment ventricular ventricular fibrillation Viral RNA viral RNA synthesis [DOI] 10.1007/s12012-021-09703-9 PMC 바로가기 [Article Type] Review