Assessment of Neutralizing Antibody Response Against SARS-CoV-2 Variants After 2 to 3 Doses of the BNT162b2 mRNA COVID-19 VaccineBNT162b2 mRNA COVID-19 백신 2~3회 투여 후 SARS-CoV-2 변이체에 대한 중화 항체 반응 평가Article Published on 2022-05-022022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 95% CI Against age all age group all age groups assessment BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine booster booster vaccination cohort study conducted COVID-19 D614G variant delta variant dose group Immunity increase in induce Japanese Kobe lowest median age men Messenger RNA mRNA much higher Neutralizing antibodies neutralizing antibody Older age omicron Omicron variant other variant other variants outcome pandemic participant Participants physician Positive test positive test result recipient recipients response SARS-CoV-2 SARS-CoV-2 pandemic test results tested the SARS-CoV-2 the vaccine titer titers university vaccination Vaccine variant variants [DOI] 10.1001/jamanetworkopen.2022.10780 PMC 바로가기 [Article Type] Article
Factors Associated With Serological Response to SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Treated With Rituximab리툭시맙으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 백신 접종에 대한 혈청학적 반응과 관련된 요인Article Published on 2022-05-022022-09-12 Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accumulated age analyzed angiotensin-converting enzyme 2 Anti-RBD IgG anti-receptor-binding domain Anti-spike anti-Spike IgG antibodies antibody B cells B-cell binding antibody CD19+ CD4+ T-cell CD8+ T-cell cellular response cohort study conducted COVID-19 infection Cutoff cutoff value Diagnosis disease dose Factor first vaccination Follow-up greater identify IgG IgG antibodies Immunoglobulin interferon gamma median monoclonal antibody Multiple multiple sclerosis Neutralizing outcome outcomes Patient patients evaluated peptide pool positive response positive test result proportion prospective cohort study quantitation RBD reached response rituximab SARS-CoV-2 sclerosis serological response spot-forming unit T-cell Response the median Treatment university hospital vaccination vaccine response Vaccines were assessed were measured women [DOI] 10.1001/jamanetworkopen.2022.11497 PMC 바로가기 [Article Type] Article
Effectiveness of BNT162b2 and ChAdOx-1 vaccines in residents of long-term care facilities in England using a time-varying proportional hazards modelObservational Study Published on 2022-05-012022-10-05 Journal: Age and Ageing [Category] COVID19(2023년), SARS, 임상, [키워드] adjusted hazard ratio adverse outcome Against BNT162b2 calculated Care COVID-19 COVID-19-related death Cox proportional hazard death defined died dose doses Effectiveness England hazard high risk highest individuals Infection intervals moderate mortality data of BNT162b2 Older older people Positive test positive test result protection provided relative SARS CoV-2 SARS-CoV-2 second dose study period Symptom tested the vaccine vaccination Vaccine vaccine effectiveness [DOI] 10.1093/ageing/afac115 PMC 바로가기 [Article Type] Observational Study
Tocilizumab in patients hospitalised with COVID-19 pneumonia: Efficacy, safety, viral clearance, and antibody response from a randomised controlled trial (COVACTA)Research article Published on 2022-04-212022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 임상, [키워드] 28-day mortality 95% CI anti-SARS-CoV-2 antibody antibody Antibody Response assessment assigned authority benefit clearance combination therapy Coronavirus disease 2019 Coronavirus disease-19 COVACTA COVID-19 Department development died discharged double-blind Effect Efficacy and safety Europe finding funding Future Hoffmann-La Roche hospital hospital discharge hospitalised Host immune response Human impair IMPROVE Infection intensive care interleukin-6 intravenous tocilizumab investigated Mortality Nasopharyngeal swab neutralising North America occurred office other treatments Patient patient selection patients with COVID-19 Placebo placebo-controlled trial polymerase chain positive test result Potential biomarker randomised randomised controlled trial Randomly respiratory response SARS-CoV-2 SARS-CoV-2 viral load Secretary serum serum samples severe acute respiratory syndrome coronavirus-2 tested Tocilizumab Treatment viral clearance Viral load with COVID-19 [DOI] 10.1016/j.eclinm.2022.101409 [Article Type] Research article
Investigation of the Presence of SARS-CoV-2 in Aerosol After Dental Treatment치과 치료 후 에어로졸 내 SARS-CoV-2 존재 조사Randomized Controlled Trial Published on 2022-04-012022-09-11 Journal: International dental journal [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] added addition aerosol Analysis assigned canine Canine tooth Chain Reaction Contamination COVID-19 COVID-19 contamination COVID-19 patients dental during treatment Elimination investigation Laboratory Operating room patients with COVID-19 PCR PCR test performed polymerase chain polymerase chain reaction positive test result Presence Prevent Randomly real-time polymerase chain reaction removal RT-PCR RT-PCR test SARS-CoV-2 Scaling Simulation specimen specimens suction tooth transport medium Treatment Viral transport medium Volume was used [DOI] 10.1016/j.identj.2021.05.002 PMC 바로가기 [Article Type] Randomized Controlled Trial
Assessment of Clinical Effectiveness of BNT162b2 COVID-19 Vaccine in US Adolescents미국 청소년에 대한 BNT162b2 COVID-19 백신의 임상 효과 평가Research Published on 2022-03-032022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 변종, [키워드] 95% CI Adolescent age assessment association asymptomatic infection B.1.617.2 black BNT162b2 BNT162b2 vaccine case-control study caused Chain Reaction clinical Clinical data Clinical symptoms clinical trial conducted Connecticut Control COVID-19 COVID-19 vaccine defined Delta delta variant dose doses effective Effectiveness elapsed estimate exposure female Final finding General population Hispanic Hospitalization hospitalizations immunization immunized Importance Increases increases in Infection IQR logistic regression models matched control measure median age median time medical record medical records negative test New objective Odds ratio of BNT162b2 participant Participants Point positive test result predominant Primary outcome receiving Relevance residence Result retrospective RT-PCR RT-PCR test SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 positivity SARS-CoV-2 test secondary setting single dose symptomatic and asymptomatic symptomatic infection symptomatic infections test result test results tested the SARS-CoV-2 the vaccine Vaccine vaccine dose vaccine doses variant of SARS-CoV-2 white [DOI] 10.1001/jamanetworkopen.2022.0935 PMC 바로가기 [Article Type] Research
Prospective surveillance study in a 1,400-bed university hospital: COVID-19 exposure at home was the main risk factor for SARS-CoV-2 point seroprevalence among hospital staff1,400개 병상을 갖춘 대학 병원의 전향적 감시 연구: 집에서 COVID-19 노출이 병원 직원 사이에서 SARS-CoV-2 점 혈청 유병률의 주요 위험 요소였습니다Article Published on 2022-03-012022-09-11 Journal: Transboundary and emerging diseases [Category] SARS, 치료기술, [키워드] 95% CI adjusted administration analysed antibody association clinical symptom Clinical symptoms Compliance COVID-19 COVID-19 test evaluated Evidence evidence of first test Germany HCW HCWs healthcare healthcare worker Healthcare workers Hospital staff IgG immunoassay immunoassays mandatory nosocomial nosocomial COVID-19 Nosocomial transmission offered outbreak participant Patient care Personal protective equipment positive test result PPE Prospective prospective cohort study questionnaire recruitment reported risk risk factor SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 seroprevalence Seroepidemiologic studies Seroprevalence Surveillance test result Universal masking university with COVID-19 [DOI] 10.1111/tbed.14041 PMC 바로가기 [Article Type] Article
Low transferrin levels predict heightened inflammation in patients with COVID-19: New insights낮은 트랜스페린 수치는 COVID-19 환자의 염증 증가를 예측합니다: 새로운 통찰력Article Published on 2022-03-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] anti-SARS-CoV-2 antibodies association Biomarker Blood level blood levels C-reactive protein can be used COVID-19 CRP CRP levels cytokine Cytokine storm disease severity Evidence ferritin ferritin level ferritin levels hospitalized patient Hyperferritinemia hyperinflammation IgG levels IgM and IgG IL-6 ill patient immune increase in Inflammation Inflammatory interleukin interleukin 6 involved iron marker Mild Mounting New parameter Patient positive test result predict predicted progression SARS-CoV-2 serum Serum iron severe COVID-19 severity significant increase Symptom symptom severity test results the disease Transferrin Transferrin saturation. two group two groups Variation variations were measured [DOI] 10.1016/j.ijid.2021.12.340 PMC 바로가기 [Article Type] Article
SARS-CoV-2 rapid antigen test in comparison to RT-PCR targeting different genes: A real-life evaluation among unselected patients in a regional hospital of ItalySARS-CoV-2 신속항원 검사와 다른 유전자 표적 RT-PCR 비교: 이탈리아 지역 병원에서 선별되지 않은 환자를 대상으로 한 실생활 평가Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigen detection Calabria caution Chain Reaction coronavirus Cycling diagnostic Discordance gene target high viral load hospital identify indicated Infection IRCCS Italy molecular test Negative predictive value PanBio Panbio™ COVID-19 Patient polymerase chain reaction positive Positive predictive value Positive test positive test result Predictive value presenting Prevalence processed RAD reverse transcriptase RT-PCR SARS-CoV-2 Sensitivity and specificity severe acute respiratory syndrome Coronavirus shown significantly lower stratified subject Support Swab swabs test result tested threshold Viral load Volume [DOI] 10.1002/jmv.27378 PMC 바로가기 [Article Type] Article
Association of COVID-19 Quarantine Duration and Postquarantine Transmission Risk in 4 University CohortsResearch Published on 2022-02-252022-10-29 Journal: JAMA Network Open [Category] COVID-19, MERS, [키워드] 95% CI African American age Asian association Asymptomatic black center close contact cohort study Control COVID-19 COVID-19 infection Date Duration evaluate exposure finding first positive Follow-up Guidance Hispanic Importance individual Interaction IQR Latinx less maintain measure median negative test objective participant Participants Point polymerase chain positive positive test result Quantitative quarantine Relevance Result risk SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV-2–positive setting tested Transmission university white [DOI] 10.1001/jamanetworkopen.2022.0088 PMC 바로가기 [Article Type] Research